Single-wall carbon nanotubes based anticancer drug delivery system

Tripisciano, Carla; Kraemer, Kai; Taylor, Arthur; Borowiak‐Palen, E.

doi:10.1016/j.cplett.2009.07.071

Cited by 151 publications

(79 citation statements)

References 15 publications

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“…There are no FDA approvals or clinical trials in process up to date using carbon nanotubes, although the encouraging preclinical results in vitro and in vivo in cancer treatment via passive targeting show that this structures are promising nanocarriers for cancer treatment [18,126,296,297,300,[307][308][309][310][311][312][313][314][315][316]. Active tumor targeting has been rarely reported in vivo [300,317,318], usually without drug loading [301,303,319].…”

Section: Carbon Nanotubesmentioning

confidence: 99%

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

Pérez-Herrero

Fernández‐Medarde

2015

European Journal of Pharmaceutics and Biopharmaceutics

1,312

709

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Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases. It is characterized by uncontrolled cell proliferation and an absence of cell death that, except for hematological cancers, generates an abnormal cell mass or tumor. This primary tumor grows thanks to new vasculatization and, in time, adquires metastatic potential and spreads to other body sites, which causes metastasis and finally death. Cancer is caused by damage or mutations in the genetic material of the cells due to environmental or inherited factors. While surgery and radiotherapy are the primary treatment used for local and non-metastatic cancers, anti-cancer drugs (chemotherapy, hormone and biological therapies) are the choice currently used in metastasic cancers. Chemotherapy is based on the inhibition of the division of rapidly growing cells, which is a characteristic of the cancerous cells, but unfortunately, it also affects normal cells with fast proliferation rates, like the hair follicles, bone marrow and gastrointestinal tract cells, generating the characteristic side effects of chemotherapy. The indiscriminate destruction of normal cells, the toxicity of conventional chemotherapeutic Código de campo cambiado

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Section: Carbon Nanotubesmentioning

confidence: 99%

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

Pérez-Herrero

Fernández‐Medarde

2015

European Journal of Pharmaceutics and Biopharmaceutics

1,312

709

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“…[37][38][39][40] Pt(IV)-conjugated CNTs were constructed to effectively deliver cisplatin (cis-dichlorodiammineplatinum, CDDP). [41][42][43][44][45][46][47][48] Dhar et al 41 developed amine-functionalized SWCNTs (SWCNTs-phospholipid-PEG-NH 2 ) as a "longboat delivery system" for Pt-based CDDP. A complex of folate and CDDP was linked to amide bonds of SWCNTs to comprise the "longboat", which was internalized into cancer cells by endocytosis.…”

Section: Cnts As Pt-based Drug Carriersmentioning

confidence: 99%

“…Next, CDDP release and subsequent interactions between the nucleus and CDDP progressed. Tripisciano et al 42 also evaluated CDDP-embedded SWCNTs using a wet chemical approach. The in vitro release profile of CDDPSWCNTs was smooth until 72 hours, and the maximum release percentage was 68%.…”

Section: Cnts As Pt-based Drug Carriersmentioning

confidence: 99%

Carbon nanotubes as cancer therapeutic carriers and mediators

Son¹,

Hong²,

Lee³

2016

IJN

206

104

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Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers. CNTs can also deliver proteins and immunotherapy components. Using combinations of light energy, they have also been applied as mediators for photothermal therapy and photodynamic therapy to directly destroy cancer cells without severely damaging normal tissue. If limitations such as a long-term cytotoxicity in the body, lack of size uniformity during the synthetic process, loading deviations for drug–CNT complexes, and release controllability at the target point are overcome, CNTs will become one of the strongest tools that are available for various other biomedical fields as well as for cancer therapy.

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“…Indeed, their ability to cross cell membranes [2] opens innumerable possibilities for biomedical applications [3,4]. Their large surface area allows attachment (of chemical or physical nature) of drug molecules [5][6][7] and the empty core of the CNTs provides an opportunity to exploit them as nano-containers for drug [8,9] or any desired biologically active molecule encapsulation [10,11]. For this reason, several experimental studies have been performed in order to understand the pathways of internalization [12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Spontaneous insertion of carbon nanotube bundles inside biomembranes: A hybrid particle-field coarse-grained molecular dynamics study

Sarukhanyan¹,

Roccatano²,

Kawakatsu³

et al. 2014

Chemical Physics Letters

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The processes of CNTs bundle formation and insertion/rearrangement inside lipid bilayers, as models of cellular membranes, is described and analyzed in details using simulations on the microsecond scale. Molecular Dynamics simulations employing hybrid particle-field models (MD-SCF) show that during the insertion process lipid molecules coat bundles surfaces The distortions of bilayers are more pronounced for systems undergoing to insertion of bundles made of longer CNTs. Interestingly, in this case, for the insertion of bundles in perpendicular orientation, it has been possible to observe, for the first time, a transient poration of the bilayer and a subsequent water percolation through it.

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Single-wall carbon nanotubes based anticancer drug delivery system

Cited by 151 publications

References 15 publications

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

Carbon nanotubes as cancer therapeutic carriers and mediators

Spontaneous insertion of carbon nanotube bundles inside biomembranes: A hybrid particle-field coarse-grained molecular dynamics study

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