Single voxel proton MR spectroscopy findings of typical and atypical intracranial meningiomas

Demir, Mustafa Kemal; İplikçioğlu, A. Celal; Di̇nçer, Alp; Arslan, Mahmut; Sav, Aydın

doi:10.1016/j.ejrad.2006.06.002

Cited by 75 publications

(40 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When comparing human patients and dogs with brain tumors, certain amino acids, including Ala, Pro and Ile, were increased in the two species according to the present and previous studies (13,19,20). By contrast, specific amino acids, such as Met, taurine, Lys, Ser, Phe and Gln were increased only in human patients (13,19).…”

Section: Discussionmentioning

confidence: 62%

“…In another study, amino acid levels in surgically removed glioma and peritumoral tissues were measured, and significantly increased levels of Ile and Val were identified within the peritumoral tissue compared with those in normal brain tissue (13). In MRS studies of human meningioma, increased alanine levels were observed in 91.3% of cases (20). Although the mechanism underlying these amino acid changes are not clear, they may be due to downregulation of amino acid transporter expression, such as L-type amino acid transporter 1 (LAT1), in tumor cells.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Analysis of plasma free amino acid profiles in canine brain tumors

et al. 2016

View full text Add to dashboard Cite

Abstract. Canine brain tumors are best diagnosed using magnetic resonance imaging (MRI). However, opportunities of MRI examination are restricted due to its limited availability in veterinary facilities; thus, numerous canine brain tumors are diagnosed at an advanced stage. Therefore, development of a noninvasive diagnostic biomarker is required for the early detection of brain tumors. In the present study, plasma free amino acid (PFAA) profiles between dogs with and without brain tumors were compared. A total of 12 dogs with brain tumors, diagnosed based on clinical signs, and on the results of intracranial MRI and/or pathological examination were evaluated. In addition, eight dogs diagnosed with idiopathic epilepsy and 16 healthy dogs were also included. A liquid chromatography system with automated pre-column derivatization functionality was used to measure the levels of 20 amino acids. As a result, the levels of three amino acids (alanine, proline and isoleucine) were increased significantly (1.6-, 1.5-and 1.6-fold, respectively) in the plasma of dogs with brain tumors as compared with the levels in control dogs (all P<0.05). Thus, the PFAA levels of dogs with brain tumors differed from those of healthy dogs. The present study demonstrated that analysis of PFAA levels of dogs with brain tumors may serve as a useful biomarker for the early detection of canine brain tumors.

show abstract

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Analysis of plasma free amino acid profiles in canine brain tumors

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Newer imaging techniques such as Diffusion-weighted (DWI), MR perfusion (MRP), Diffusion Tensor Imaging (DTI), and MR spectroscopy (MRS) have been investigated in smaller series with lesser success and conflicting results. [25][26][27][28][29][30][31]. Our study shows that the conventional MR imaging may be used to differentiate between benign and atypical/malignant meningiomas via grade 4/4 vascularity, but high grade vascularity is of lesser importance than previous history of CVA.…”

Section: Discussionmentioning

confidence: 92%

Distinguishing Grade I Meningioma From Higher Grade Meningiomas Without Biopsy

Tangel

Flickinger

Pavelic

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

show abstract

“…Increased Ala has been observed in vivo in meningiomas (23) and less frequently in other tumors. In NN tumors ( Figure 3) the Ala increase is attributed not only to typical tumor pathways but also to the composition of original tumor cells since Ala concentration is three times higher in meningeal cells than in neurons (24). In addition, aggressive tumors such as metastasis and Hg tumors, usually have higher amounts of lipids that can cause an overlap with Ala peak in vivo, potentially preventing its precise measurement (21).…”

Section: Discussionmentioning

confidence: 99%

Classification of brain tumor extracts by high resolution ¹H MRS using partial least squares discriminant analysis

Faria

Macedo

Marsaioli

et al. 2011

Braz J Med Biol Res

View full text Add to dashboard Cite

High resolution proton nuclear magnetic resonance spectroscopy ( 1 H MRS) can be used to detect biochemical changes in vitro caused by distinct pathologies. It can reveal distinct metabolic profiles of brain tumors although the accurate analysis and classification of different spectra remains a challenge. In this study, the pattern recognition method partial least squares discriminant analysis (PLS-DA) was used to classify 11.7 T 1 H MRS spectra of brain tissue extracts from patients with brain tumors into four classes (high-grade neuroglial, low-grade neuroglial, non-neuroglial, and metastasis) and a group of control brain tissue. PLS-DA revealed 9 metabolites as the most important in group differentiation: γ-aminobutyric acid, acetoacetate, alanine, creatine, glutamate/glutamine, glycine, myo-inositol, N-acetylaspartate, and choline compounds. Leave-one-out crossvalidation showed that PLS-DA was efficient in group characterization. The metabolic patterns detected can be explained on the basis of previous multimodal studies of tumor metabolism and are consistent with neoplastic cell abnormalities possibly related to high turnover, resistance to apoptosis, osmotic stress and tumor tendency to use alternative energetic pathways such as glycolysis and ketogenesis.

show abstract

Single voxel proton MR spectroscopy findings of typical and atypical intracranial meningiomas

Cited by 75 publications

References 18 publications

Analysis of plasma free amino acid profiles in canine brain tumors

Analysis of plasma free amino acid profiles in canine brain tumors

Distinguishing Grade I Meningioma From Higher Grade Meningiomas Without Biopsy

Classification of brain tumor extracts by high resolution ¹H MRS using partial least squares discriminant analysis

Contact Info

Product

Resources

About