Single-visit venous ulcer assessment clinic: The first year

Hartshorne, T.; Scriven, J. M.; Bell, P. R. F.; Naylor, A.R.; London, N. J. M.

doi:10.1002/bjs.1800840319

Cited by 75 publications

(20 citation statements)

References 7 publications

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“…In conclusion, FXIII may play different roles in chronic wound healing, mainly in reference to its antifibrinolytic activity that negates the MMP activation process and to its cross‐linking properties toward ECM components, both in turn favoring healing processes. We are aware that several other known clinical factors can influence venous ulcer outcome, such as infections, time from onset, patient compliance to treatments, number of recurrences, pattern of reflux, and walking ability 30–33 . Although all of these factors can strongly affect healing time and sometimes, in turn the ulcer size, it is worthy to note that our patients were all treated in accordance with the recommended standards for ulcer care, as described in detail in the method section, and the rate of distribution of the above‐mentioned factors was equivalent in our survey to that reported in several epidemiologic observations 30–32 .…”

Section: Discussionsupporting

confidence: 50%

Factor XIII V34L polymorphism modulates the risk of chronic venous leg ulcer progression and extension

Gemmati

Tognazzo

Serino

et al. 2004

Wound Repair Regeneration

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Low Factor XIII (FXIII) activity has been reported in the blood of patients with chronic venous leg ulcer (CVU). In vivo studies have described increased wound healing in CVU patients treated with FXIII concentrate, and in vitro studies have shown increased regenerative capacity in FXIII-treated fibroblasts. In addition, a common G-to-T polymorphism in the FXIIIA-subunit gene (V34L) significantly increases the activity and modifies the cross-linking properties of the FXIII molecule and this variant has been investigated as a protective factor against thrombosis, a recognized risk factor for CVU establishment. Therefore, the role of FXIII levels, FXIII V34L, FVR506Q, and FIIG20210A, common gene polymorphisms in the pathogenesis of CVU was investigated. Ninety-one patients with CVU and 195 healthy controls (91 of them sex- and age-matched) were PCR-genotyped for the FXIIIV34L, FVR506Q, and FIIG20210A substitutions and FXIIIA-subunit levels were determined by immuno-electrophoresis. The extent of the venous ulcer surface in patients was measured by computer software. The allele frequency and the genotype distribution of the FXIII polymorphism did not show significant differences between the whole group of cases and controls as well as prothrombin variants did. On the contrary, the FVR506Q variant (FV Leiden) allele was more frequent in patients, yielding a significant OR value of 5.93 (95 percent CI, 1.83-19.17; p= 0.003). Considering only CVU cases secondary to a post-thrombotic syndrome (n= 24), FV Leiden yielded a greater OR value of 16.08 (95 percent CI, 4.33-59.6; p < 0.0001). When the CVU cases were stratified by the three possible FXIII genotypes, a significant trend toward a lower mean value of the ulcerated area was clearly evident as the number of the polymorphic alleles (L34) increased in the genotype of patients (VV = 11.9 cm(2,)+/- 23.6; VL = 6.1 cm(2,)+/- 6.9; LL = 4.1 cm(2,)+/- 2.8; p= 0.01). On the other hand, FXIIIA antigen levels were similar between CVU cases and matched controls, but 11 percent of cases had FXIII deficiency (FXIIIA

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Section: Discussionsupporting

confidence: 50%

Factor XIII V34L polymorphism modulates the risk of chronic venous leg ulcer progression and extension

Gemmati

Tognazzo

Serino

et al. 2004

Wound Repair Regeneration

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“…At present, hospital referral tends to be the last resort, when care in the community has failed and the ulcer is embedded in chronic scar tissue. The best time for specialist input is at the outset, giving patients the opportunity for a thorough diagnostic and prognostic evaluation in hospital including duplex scanning of the arterial and venous systems 11. Such evaluation identifies patients who would benefit from early treatment of vascular disease, combined, if appropriate, with skin grafting.…”

mentioning

confidence: 99%

Caring for patients with chronic leg ulcer

Ruckley

1998

BMJ

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“…Doppler ultrasound to measure ABPI should also be conducted when the ulcer is deteriorating, ulcer not healed fully by 12 weeks, sudden increase in size of ulcer, sudden increase in pain, foot color or temperature change, or there is recurrence of ulcer (evidence Level B). [131415]…”

Section: Recommendationsmentioning

confidence: 99%