Single umbilical artery

Vanleeuwen, G; Behringer, Blair R.; Glenn, Luther D.

doi:10.1016/s0022-3476(67)80237-3

Cited by 41 publications

(6 citation statements)

References 11 publications

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“…In the most common form, after developing from either the dorsal aorta or internal iliac artery, one of the umbilical arteries regresses. The fusion of both umbilical arteries, proximal or distal to the 1958 1960 1961 1961 1962 1964 1964 1964 1964 1965 1965 1966 1966 1966 1967 1967 1967 1967 1968 1968 1969 1969 1969 1970 1971 1972 1972 1972 1973 1974 1975 umbilical ring, resulting in a single artery is also documented as a less common variant [Beck et al, 1973;Benirschke, 1990;Van Leeuwen et al, 1967;Warkany, 19711. In this study we found evidence of umbilical artery fusion in only one of the 62 SUA cases.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast SUA has been observed in 2.2 to 12% of late spontaneous abortions and perinatal deaths [Kristoffersen, 19691. Although SUA may coexist with a variety of abnor- 'M = male; NI = not identifiable; F = female. malities, it has been found particularly in association with malformations of the renal, skeletal, gastrointestinal, cardiovascular, and central nervous systems [Benirschke and Brown, 1955;Benirschke, 1990;Bryan and Kohler, 1974;Cairns and McKee, 1964;Fujikura, 1966, 1973;Feingold and Pashayan, 1983;Hata et al, 1986;Herva and Karkinen, 1984;Mehes, 1988;Nyberg et al, 1988;Seki and Strauss, 1964;Smith and Jones, 1982;Soma, 1976;Van Leeuwen et al, 1967;Warkany, 19711. In some instances, chromosome abnormalities may also be present (trisomy 13, trisomy 18) [Byrne and Blanc, 1985;Lenoski and Medavy, 1962;Lewis, 1962;Smith Jones, 19821.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and associations of single umbilical artery in prenatally diagnosed malformed, midtrimester fetuses: A review of 62 cases

et al. 1992

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The absence of one umbilical artery (SUA) is the most common malformation of the umbilical cord. It may accompany other abnormalities or occur as an isolated defect. We examined 885 fetuses, terminated following the prenatal diagnosis of serious or lethal malformations between April 1977 and March 1989, for the presence of SUA. We found 62 cases of SUA. This represents an incidence of 7.01% (62/885). The most common abnormalities found in association with SUA were: (1) multiple malformations (8/11 cases, SUA incidence = 72.7%), (2) ADAM complex (7/14 cases, SUA incidence = 50.%), (3) multicystic renal dysplasia (5/20 cases, SUA incidence = 25.%), and (4) Potter sequence (5/21 cases, SUA incidence = 23.8%). These associations have not been documented previously. In 6 fetuses the Meckel syndrome was diagnosed, and SUA was present in 2 of these. Therefore, SUA may represent an additional anomaly in Meckel syndrome that has not been reported previously.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incidence and associations of single umbilical artery in prenatally diagnosed malformed, midtrimester fetuses: A review of 62 cases

et al. 1992

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“…Little is known about the aetiology of the SUA syndrome. A chromosomal aetiology has been suggested on the basis of (1) the high fetal wastage (Javert, 1957;Bourne and Benirschke, 1960;Thomas, 1963); (2) the wide variety of severe congenital malformations; and (3) the reported association of SUA with trisomy (especially trisomy-18 and -13, but also mongolism) and with gonadal dysgenesis (Richart and Benirschke, 1958;German et al, 1962;Uchida, Bowman, and Wang, 1962;Lewis, 1962;Feingold et al, 1964;Gustavson, 1964;Gustavson et al, 1964;Seki and Strauss, 1964;VanLeeuwen et al, 1967;Dellenbach et al, 1968). As a result of our series of patients where chromosomes and dermatoglyphs were studied, we are led to conclude that SUA is no more than a fortuitous organ manifestation of trisomy.…”

Section: Resultsmentioning

confidence: 99%

Significance of the Single Umbilical Artery: A Clinical, Radiological, Chromosomal, and Dermatoglyphic Study

Vlietinck¹,

Thiery²,

Orye³

et al. 1972

Archives of Disease in Childhood

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P. (1972). Archives of Disease in Childhood, 47, 639. Significance of the single umbilical artery: a clinical, radiological, chromosomal, and dermatoglyphic study. A single umbilical artery is present in about 1% of all singletons. It is associated with a wide range of congenital malformations. Chromosomal analysis of our surviving cases gave normal results. Dermatoglyphic patterns were normal, except that the boys showed a three-to fourfold increase in the number of the radial loops on the fingers, and a lowering of the total finger ridge count. Evidence favouring a common non-genetic cause for both a single umbilical artery and the associated malformations is discussed.Although the absence of one umbilical artery was first reported a century ago (Hyrtl, 1870), the significance of a single umbilical artery (SUA) has only been realized since a retrospective study by Benirschke and Brown (1955) showed it was associated with increased incidence of congenital anomalies. Because most of the investigations on SUA have been made by pathologists, the conclusions drawn may not be applicable to the live infant population. And because most of these studies are retrospective, they may also be biased with respect to the incidence of congenital malformations.The present report concerns a prospective study carried out in a consecutive series of 2572 singletons born in the same hospital and followed up over a period of several years by means of a planned investigative programme including intravenous pyelography (IVP), chromosome patterns, and dermatoglyphs. MethodsIn this investigation the umbilical cord was studied in various ways: gross examination of the freshly delivered umbilical cord and placenta; re-examination after fixation for one week in 10% formaldehyde, followed by the study of H. and E.-stained paraffin sections prepared from the middle portion of the cord.All children with SUA who succumbed during the perinatal period were necropsied. Follow-up study of the survivors included clinical examination, IVP, and Received 13 December 1971. investigation of the karyotype and dermatoglyphs.The mean age at the last examination was 21 months (range, 5 months to 31 years). ResultsIncidence and mortality. In 29 of the 2572 consecutive cords examined (1-1 %), one umbilical artery was lacking. The significance of SUA, and its association with such factors as birthweight, maternal pathology, and placental pathology have been discussed elsewhere (de Clercq et al., 1970).Of the 29 children with SUA, 4 were stillborn and 2 died neonatally, giving a perinatal mortality rate of 21%. Half of the stillborn fetuses (2/29: 7%) showed congenital malformations (Table I).Of the 23 children with SUA still living, 22 were given a complete clinical and neurological examination. In one case examination was refused by the parents; this child had been found to be grossly normal at birth and showed no malformations at

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“…They found an incidence of congenital urologic malformations that ranged from 0% to 33% [25][26][27][28][29][30][31][32]. These studies are identified and listed in Table 2.…”

Section: Incidence Of Genitourinary Malformations In Children With Simentioning

confidence: 99%

Urologic anomalies and two-vessel umbilical cords: What are the implications?

Johnson

Tennenbaum²

2003

Curr Urol Rep

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A two-vessel umbilical cord (or single umbilical artery) is a perinatal finding that may be detected in infants with congenital or chromosomal abnormalities. Its presence has been associated with an increased risk of genitourinary defects. The urologic anomalies that typically are associated with a two-vessel cord often are minor and self-limiting. These defects usually can be detected perinatally in routine prenatal screening ultrasonographic examinations. The neonatal physical examination, an additional postnatal ultrasonography, and possibly a voiding cystourethrogram will be sufficient to complete the screening for genitourinary abnormalities in children with a single umbilical artery. Infants with two-vessel umbilical cords do not require additional screening for genitourinary defects, unless the imaging or amniocentesis detects a genitourinary abnormality. This review details the history of two-vessel cords and the associated genitourinary anomalies.

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Single umbilical artery

Cited by 41 publications

References 11 publications

Incidence and associations of single umbilical artery in prenatally diagnosed malformed, midtrimester fetuses: A review of 62 cases

Incidence and associations of single umbilical artery in prenatally diagnosed malformed, midtrimester fetuses: A review of 62 cases

Significance of the Single Umbilical Artery: A Clinical, Radiological, Chromosomal, and Dermatoglyphic Study

Urologic anomalies and two-vessel umbilical cords: What are the implications?

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