Single trial-based prediction of a go/no-go decision in monkey superior colliculus

Hasegawa, Ryohei; Hasegawa, Yukako T.; Segraves, Mark A.

doi:10.1016/j.neunet.2006.05.035

Cited by 21 publications

(8 citation statements)

References 38 publications

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“…Conversely, feedback pathways from the frontal eye fields to the superior colliculus are involved in the execution and correction of the saccades, once the decision has been taken by the superior colliculus ‘about where to look and where not to look’ (Schiller et al , 2001, 2005). Recordings from the superior colliculus in monkeys adequately predict if a Go or No-Go decision will be executed (Hasegawa et al , 2006). Usually, the basal ganglia tonically inhibit the superior colliculus, but disinhibition is required for saccade initiation.…”

Section: Pathophysiologymentioning

confidence: 99%

Are patients with Parkinson’s disease blind to blindsight?

Diederich

Stebbins

Schiltz

et al. 2014

Brain

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Diederich et al. propose that patients with Parkinson’s disease are “blind to blindsight” as they show preserved conscious vision, but erroneous “guess” localization of visual stimuli, poor saccades/motion perception, and poor emotional face perception with blunted autonomic reactions. Changes may reflect dysfunction of the phylogenetically old subconscious retino-colliculo-thalamo-amygdala and retino-geniculo-extrastriate pathways.

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Section: Pathophysiologymentioning

confidence: 99%

Are patients with Parkinson’s disease blind to blindsight?

Diederich

Stebbins

Schiltz

et al. 2014

Brain

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show abstract

“…Despite physiological evidence [35], a causal relationship between preparatory signals in the superior colliculus and saccade triggering is still debated because lesions or inactivations confined to the superior colliculus in man or animals have not led to clear saccade initiation deficits. Saccadic dysfunction was, however, recently demonstrated in a patient presenting a bilateral superior colliculus lesion [36 ].…”

Section: Control Of Saccade Initiation and Saccadic Intrusionsmentioning

confidence: 99%

Ocular motor syndromes of the brainstem and cerebellum

Tilikete

Pélisson

2008

Current Opinion in Neurology

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The main recent findings of great interest for clinical practice or research concern the physiopathology of head shaking nystagmus, downbeat nystagmus and oculopalatal tremor; the neural substrates of three-dimensional control of eye movements and of optokinetic nystagmus; the understanding of saccade generation and of its consequences on physiological and pathological eye oscillations; and, finally, the physiological basis of saccadic adaptation.

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“…Hasegawa et al (Hasegawa et al, 2006, 2009) implemented decoding algorithms that served a similar purpose that we describe here. They decoded go/no go decisions from the activity of 2–5 neurons recorded in monkey superior colliculus and were able to extract multidimensional decisions (e.g., go/no go for two potential movement directions).…”

Section: Discussionmentioning

confidence: 99%

Reprogramming movements: extraction of motor intentions from cortical ensemble activity when movement goals change

Ifft¹,

Lebedev²,

Nicolelis³

2012

Front. Neuroeng.

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The ability to inhibit unwanted movements and change motor plans is essential for behaviors of advanced organisms. The neural mechanisms by which the primate motor system rejects undesired actions have received much attention during the last decade, but it is not well understood how this neural function could be utilized to improve the efficiency of brain-machine interfaces (BMIs). Here we employed linear discriminant analysis (LDA) and a Wiener filter to extract motor plan transitions from the activity of ensembles of sensorimotor cortex neurons. Two rhesus monkeys, chronically implanted with multielectrode arrays in primary motor (M1) and primary sensory (S1) cortices, were overtrained to produce reaching movements with a joystick toward visual targets upon their presentation. Then, the behavioral task was modified to include a distracting target that flashed for 50, 150, or 250 ms (25% of trials each) followed by the true target that appeared at a different screen location. In the remaining 25% of trials, the initial target stayed on the screen and was the target to be approached. M1 and S1 neuronal activity represented both the true and distracting targets, even for the shortest duration of the distracting event. This dual representation persisted both when the monkey initiated movements toward the distracting target and then made corrections and when they moved directly toward the second, true target. The Wiener filter effectively decoded the location of the true target, whereas the LDA classifier extracted the location of both targets from ensembles of 50–250 neurons. Based on these results, we suggest developing real-time BMIs that inhibit unwanted movements represented by brain activity while enacting the desired motor outcome concomitantly.

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Single trial-based prediction of a go/no-go decision in monkey superior colliculus

Cited by 21 publications

References 38 publications

Are patients with Parkinson’s disease blind to blindsight?

Are patients with Parkinson’s disease blind to blindsight?

Ocular motor syndromes of the brainstem and cerebellum

Reprogramming movements: extraction of motor intentions from cortical ensemble activity when movement goals change

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