Single-trial analysis of auditory evoked potentials improves separation of normal and schizophrenia subjects

Iyer, Darshan; Boutros, Nash N.; Zouridakis, George

doi:10.1016/j.clinph.2011.12.021

Cited by 18 publications

(9 citation statements)

References 41 publications

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“…The above findings are in contrast to what has been observed in schizophrenia, in which, for example, patients are typically characterized by poor auditory acuity, precision, and discrimination (including in tone matching) (Javitt et al, 1997; Rabinowicz et al, 2000; Li et al, 2002; Rojas et al, 2007; Turetsky et al, 2009; Perrin et al, 2010; Kantrowitz et al, 2013), impairments in sound localization (Perrin et al, 2010), temporal resolution of sound (Foucher et al, 2007), auditory backward masking (Kallstrand et al, 2002), pre-attentional processing as indicated by the (smaller) MMN ERP component (Umbricht et al, 2003), and longer latency of post-attentional auditory ERPs (Ward et al, 1991; Sevik et al, 2011; Iyer et al, 2012). Individuals with schizophrenia also have abnormal processing of speech sounds (Ngan et al, 2003; Hirano et al, 2008), are worse than other groups at detecting speech embedded in noise, and are more likely than controls to identify non-speech sounds as speech (Vercammen et al, 2008).…”

Section: Domains Of Perceptual and Cognitive Functioning That Are Strmentioning

confidence: 99%

Cognitive and Neuroplasticity Mechanisms by Which Congenital or Early Blindness May Confer a Protective Effect Against Schizophrenia

Silverstein¹,

Wang²,

Keane

2013

Front. Psychology

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Several authors have noted that there are no reported cases of people with schizophrenia who were born blind or who developed blindness shortly after birth, suggesting that congenital or early (C/E) blindness may serve as a protective factor against schizophrenia. By what mechanisms might this effect operate? Here, we hypothesize that C/E blindness offers protection by strengthening cognitive functions whose impairment characterizes schizophrenia, and by constraining cognitive processes that exhibit excessive flexibility in schizophrenia. After briefly summarizing evidence that schizophrenia is fundamentally a cognitive disorder, we review areas of perceptual and cognitive function that are both impaired in the illness and augmented in C/E blindness, as compared to healthy sighted individuals. We next discuss: (1) the role of neuroplasticity in driving these cognitive changes in C/E blindness; (2) evidence that C/E blindness does not confer protective effects against other mental disorders; and (3) evidence that other forms of C/E sensory loss (e.g., deafness) do not reduce the risk of schizophrenia. We conclude by discussing implications of these data for designing cognitive training interventions to reduce schizophrenia-related cognitive impairment, and perhaps to reduce the likelihood of the development of the disorder itself.

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Section: Domains Of Perceptual and Cognitive Functioning That Are Strmentioning

confidence: 99%

Cognitive and Neuroplasticity Mechanisms by Which Congenital or Early Blindness May Confer a Protective Effect Against Schizophrenia

Silverstein¹,

Wang²,

Keane

2013

Front. Psychology

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“…J48 classifiers were used along with Multilayer Perceptron, Bayes Net, and SVM because they have produced considerable success in the classification of experiments in neuroscience, and in the classification of patients with cognitive impairment vs. cognitively healthy patients (Iyer et al, 2012 ; Matoug et al, 2012 ; Shependom et al, 2013 ; Segovia et al, 2015 ). In our experiments, we initially differentiated a series of training data from testing data.…”

Section: Methodsmentioning

confidence: 99%

The Dissociation between Polarity, Semantic Orientation, and Emotional Tone as an Early Indicator of Cognitive Impairment

Tapia

Martínez‐Tomás

Gómez

et al. 2016

Front. Comput. Neurosci.

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The present study aims to identify early cognitive impairment through the efficient use of therapies that can improve the quality of daily life and prevent disease progress. We propose a methodology based on the hypothesis that the dissociation between oral semantic expression and the physical expressions, facial gestures, or emotions transmitted in a person's tone of voice is a possible indicator of cognitive impairment. Experiments were carried out with phrases, analyzing the semantics of the message, and the tone of the voice of patients through unstructured interviews in healthy people and patients at an early Alzheimer's stage. The results show that the dissociation in cognitive impairment was an effective indicator, arising from patterns of inconsistency between the analyzed elements. Although the results of our study are encouraging, we believe that further studies are necessary to confirm that this dissociation is a probable indicator of cognitive impairment.

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“…So, there is a possibility that the waveform extracted after performing ICA is the original signal being analysed [23]. Research on schizophrenia can be found here [29], [30].…”

Section: Independent Component Analysismentioning

confidence: 99%

Feature extraction of electroencephalogram (EEG) signal - A review

Azlan

Low

2014

2014 IEEE Conference on Biomedical Engineering and Sciences (IECBES)

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This paper presents a review on signal analysis method for feature extraction of electroencephalogram (EEG) signal. It is an important aspect in signal processing as the result obtained will be used for signal classification. A good technique for feature extraction is necessary in order to achieve robust classification of signal. Considering several techniques have been implemented for extracting features in EEG signal, we only highlight the most commonly used for schizophrenia.The techniques are Hilbert-Huang transform, Principal Component Analysis, Independent Component Analysis and Local Discriminant Bases. Despite of their drawbacks, they can be applied which depends on the aim of a research, parameters and the data collected. Nevertheless, these techniques can be modified so that the new algorithm can overcome the shortcomings of original algorithm or algorithm beforehand. The modified Local Discriminant Bases algorithm is introduced in the present paper as another powerful adaptive feature extraction technique for EEG signal which is not reported elsewhere in investigating schizophrenia.

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Single-trial analysis of auditory evoked potentials improves separation of normal and schizophrenia subjects

Cited by 18 publications

References 41 publications

Cognitive and Neuroplasticity Mechanisms by Which Congenital or Early Blindness May Confer a Protective Effect Against Schizophrenia

Cognitive and Neuroplasticity Mechanisms by Which Congenital or Early Blindness May Confer a Protective Effect Against Schizophrenia

The Dissociation between Polarity, Semantic Orientation, and Emotional Tone as an Early Indicator of Cognitive Impairment

Feature extraction of electroencephalogram (EEG) signal - A review

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