gastrointestinal stromal tumor (GIST) is a mesenchymal neoplasm that occurs throughout the gastrointestinal tract, mesentery, omentum, and retroperitoneum. We report the sonographic and computed tomographic (CT) features of a case of GIST metastatic to the scrotum and discuss the role of sonography in demonstration and diagnosis of the mass. This report illustrates that the scrotum can be a place for a metastatic GIST; radiologists should be aware of this condition, which could be otherwise mistaken for an extratesticular malignancy arising from other scrotal tissues.
Case ReportA 60-year-old man had mild abdominal pain 3 years previously. At that time, sonography and abdominopelvic CT were performed, which showed several liver lesions and a 16-cm heterogeneous enhancing mass in the left upper quadrant. A CT-guided biopsy of the liver was performed, which revealed a CD117-positive GIST. The left upper quadrant mass was resected. Despite treatment with imatinib mesylate (Gleevec; Novartis Pharmaceuticals Corporation, East Hanover, NJ) and subsequently sunitinib malate (Sutent; Pfizer Inc, New York, NY), the patient continued with slowly progressive disease. A CT scan of the abdomen and pelvis performed for restaging approximately 2 years later (Figure 1) showed an interval increase in the size of multiple solid/cystic masses in the gastrosplenic ligament, along the small bowel mesentery, and in the pelvis. Liver metastases had also increased. A second resection of several abdominal masses was performed, and final pathologic examination confirmed a high-grade sarcoma with rhabdomyoblastic differentiation consistent with spread from the patient's known GIST.