Single Tc99m Sestamibi injection, double acquisition gated SPECT after stress and during low-dose dobutamine infusion: a new suggested protocol for evaluation of myocardial perfusion

Fallahi, Babak; Beiki, Davood; Gholamrezanezhad, Ali; Moeini, Babak; Gilani, Kambiz; Eftekhari, Mohammad; Fard-Esfahani, Armaghan; Mohseni, Zhila; Saghari, Mohsen

doi:10.1007/s10554-008-9328-y

Cited by 9 publications

(7 citation statements)

References 19 publications

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“…It has been reported that the MPI-SPECT in cardiac imaging is a widely accepted test for the diagnostic and prognostic evaluation of patients with known, or suspected, CAD [10],[20]. This study indicates that MPI-SPECT may provide more accurate assessments of the extent of CAD, or the prediction of disease outcomes, than CAC alone, given that, in patients with zero CAC, some could demonstrate abnormal myocardial perfusion.…”

Section: Discussionmentioning

confidence: 72%

“…Myocardial perfusion imaging (MPI) with gated single photon emission computed tomography (SPECT) has been widely used in the diagnosis of CAD and risk stratification with high diagnostic accuracy[10],[11] when compared to CT angiography. The presence of ischemia could be used to classify the patients as having CAD and candidates for receiving aggressive medical therapy and management.…”

Section: Introductionmentioning

confidence: 99%

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A head-to-head comparison of the coronary calcium score by computed tomography with myocardial perfusion imaging in predicting coronary artery disease

Almoudi¹,

Sun²

2013

Journal of Geriatric Cardiology

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ObjectivesThe coronary artery calcium (CAC) score has been shown to predict future cardiac events. However the extent to which the added value of a CAC score to the diagnostic performance of myocardial perfusion imaging (MPI) by single photon emission computed tomography (SPECT) is unclear. The purpose of this study is to investigate the correlation between CAC score and SPECT in patients with suspected coronary artery disease.MethodsA retrospective review of the CAC scores by use of the Agatston calcium scoring method and cardiac SPECT diagnostic reports was conducted in 48 patients, who underwent both coronary computed tomography (CT) and SPECT examinations due to suspected coronary artery disease. A Pearson correlation test was used to determine the relation between CAC scores and MPI-SPECT assessments with regard to the evaluation of the extent of disease.ResultsForty-seven percent of the patients had CAC scores more than 100, while 42% of these patients demonstrated abnormal, or probably abnormal, MPI-SPECT. Of the 23% of patients with a zero CAC score, only 7% had normal MPI-SPECT findings. No significant correlation was found between the CAC scores and MPI-SPECT assessments (r value ranged from 0.012 to 0.080), regardless of the degree of coronary calcification.ConclusionsThere is a lack of correlation between the CAC scores and the MPI-SPECT findings in the assessment of the extent of coronary artery disease. CAC scores and MPI-SPECT should be considered complementary approaches in the evaluation of patients with suspected coronary artery disease.

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Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

A head-to-head comparison of the coronary calcium score by computed tomography with myocardial perfusion imaging in predicting coronary artery disease

Almoudi¹,

Sun²

2013

Journal of Geriatric Cardiology

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“…These images were still plagued with attenuation issues and were reported to be "taken up and retained" within minutes of intravenous injections. Despite the report by DuPont (Crane 1993) and multiple other research and clinical (Everett 1977, Fleming 1992b, 2003e, Aodah 2007, Fallahi 2008) studies discussed above and below, which have clearly established that these isotopes redistribute and do not "stick", most clinicians have continued to ignore Blumgart's teaching of performing sequential evaluations under same state conditions and have subsequently limited their investigation of coronary artery disease to single post-stress imaging despite the teaching of nuclear imaging which notes that "a better indicator of organ function is the change in the activity in a particular organ with time." Newer clinical observations and publications (Sheikine 2010) have since been made confirming our earlier observations from 2000-2001. Inconsistencies in analysis of cardiac imaging have led some researchers (Fleming 2002b, Toriyama 2005, Oregon 2008) to recommend that these clinical studies be standardized quantitatively; something this study has accomplished.…”

Section: Discussionmentioning

confidence: 99%

Fleming-Harrington Redistribution Wash-in Washout (FHRWW): The Platinum Standard for Nuclear Cardiology

Fleming¹,

Harrington²

2011

Establishing Better Standards of Care in Doppler Echocardiography, Computed Tomography and Nuclear Cardiology

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“…Myocardial perfusion imaging (MPI) with stress gated SPECT has been widely used in the diagnosis of CAD and is a well-documented non-invasive method for risk stratification with high diagnostic accuracy when compared to coronary CT angiography [30,31]. The presence of ischemia could be used to classify the patients as having CAD and candidates for receiving aggressive medical therapy and management.…”

Section: Journal Ofmentioning

confidence: 99%

Cardiac Imaging Modalities in the Diagnosis of Coronary Artery Disease

Sun¹

2013

J Clin Exp Cardiolog

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Coronary artery disease is the leading cause of death in advanced countries. Early detection and diagnosis of coronary artery disease plays an important role in the identification of disease severity and prediction of disease outcome, consequently improving patient management. Diagnosis and management of coronary artery disease is increasingly dependent on less-invasive imaging modalities, including coronary CT angiography, cardiac magnetic resonance imaging, cardiac radionuclide imaging such as SPECT and PET modalities. Rapid developments of these imaging modalities have significantly improved the diagnostic performance of each imaging technique with high diagnostic accuracy achieved in both diagnostic and prognostic value in coronary artery disease. This editorial provides an overview of the diagnostic applications of a variety of less-invasive imaging modalities in the diagnosis of coronary artery disease. This special issue of "Arteriosclerotic Vascular Disease: Part II" in the journal of Clinical and Experimental Cardiology will give particular attention to contributions focusing on the clinical applications of these imaging modalities in the arteriosclerotic vascular disease, in particular, coronary artery disease.

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Single Tc99m Sestamibi injection, double acquisition gated SPECT after stress and during low-dose dobutamine infusion: a new suggested protocol for evaluation of myocardial perfusion

Cited by 9 publications

References 19 publications

A head-to-head comparison of the coronary calcium score by computed tomography with myocardial perfusion imaging in predicting coronary artery disease

A head-to-head comparison of the coronary calcium score by computed tomography with myocardial perfusion imaging in predicting coronary artery disease

Fleming-Harrington Redistribution Wash-in Washout (FHRWW): The Platinum Standard for Nuclear Cardiology

Cardiac Imaging Modalities in the Diagnosis of Coronary Artery Disease

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