Single subcutaneous injection of the minocycline nanocomposite-loaded thermosensitive hydrogel for the effective attenuation of experimental autoimmune uveitis

Zhu, Yutuo; Hu, Yuhan; Shi, Hui; Wu, Yiping; Panmin, Mengqi; Chen, Jinrun; Mo, Li‐Hua; Bao, Zhishu; Qu, Jia; Li, Xingyi

doi:10.1016/j.ijpharm.2022.121836

Cited by 6 publications

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is important to pay attention to the hazards of NPs, such as the potential toxicity of some NPs, which may be harmful to the retina. With the deepening of the research on NPs, the use of NPs is becoming more and more extensive, and NPs can also be used to treat proliferative vitreoretinopathy (PVR), retinal inflammation caused by autoimmune uveitis [150,151]. With the development of nanotechnology, many new fields have also been derived, such as biomimetic nanosponges [152].…”

Section: Challenges and Conclusionmentioning

confidence: 99%

Exploration: Nanoparticles in the Diagnosis and Treatment of Retinal Diseases

Wang

Xie

Chen

et al. 2023

Journal of Nanomaterials

View full text Add to dashboard Cite

In recent years, research on nanoparticles (NPs) has brought a new phase in the development of medicine. The term “NPs” refers to nanoscale particles, typically between 10 and 1,000 nm in size, that are within the range of cellular and molecular structures. Compared with traditional ophthalmic drugs, NPs can carry drugs to overcome obstacles, target drug delivery, prolong drug release, reduce drug toxicity, and can be used in gene therapy. After a brief introduction to the classification of NPs, we will focus on the potential applications of different NPs in the diagnosis and treatment of different retinal diseases and introduce innovative methods derived from NPs.

show abstract

Section: Challenges and Conclusionmentioning

confidence: 99%

Exploration: Nanoparticles in the Diagnosis and Treatment of Retinal Diseases

Wang

Xie

Chen

et al. 2023

Journal of Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Blocking the effect of galectin-3 [ 43 ] or nuclear factor erythroid 2-related factor 2 [ 44 ] robustly decreases the activation of microglia and inflammatory pathways and the release of proinflammatory factors, ultimately attenuating the clinical and histological manifestations of EAU. Additionally, microglial reactivity and the inflammatory response are substantially impeded by a single subcutaneous injection of minocycline hydrogel loaded on nanocomposite, resulting in a notable decrease in EAU scores [ 45 ]. What’s more, research on the EIU model has also drawn similar conclusions.…”

Section: Link Between Microglial Activation and Uveitismentioning

confidence: 99%

Relationship between Uveitis and the Differential Reactivity of Retinal Microglia

Gao,

Jin,

Zhou

et al. 2023

Ophthalmic Res

View full text Add to dashboard Cite

Uveitis, a complicated group of ocular inflammatory diseases, can be affected by massive pathogenic contributors such as infection, autoimmunity, and genetics. Although it is well known that many pathological changes, including disorders of the immune system and disruption of the blood-retinal barrier, count much in the onset and progression of uveitis, there is a paucity of safe and effective treatments, which has exceedingly hindered the appropriate treatment of uveitis. As innate immune cells in the retina, microglia occupy a salient position in retinal homeostasis. Many studies have reported the activation of microglia in uveitis and the mitigation of uveitis by interfering with microglial reactivity, which strongly implicates microglia as a therapeutic target. However, it has been increasingly recognized that microglia are a nonhomogeneous population under different physiological and pathological conditions, which makes it essential to thoroughly have knowledge of their specific characteristics. The paper outlines the various properties of activated microglia in uveitis, summarizes the connections between their polarization patterns and the manifestations of uveitis, and ultimately is intended to enhance the understanding of microglial versatility and expedite the exploration of promising strategies for visual protection.

show abstract