Single-step ultra-purified alginate gel implantation in patients with knee chondral defects
Tomohiro Onodera,
Daisuke Momma,
Masatake Matsuoka
et al.
Abstract:AimsImplantation of ultra-purified alginate (UPAL) gel is safe and effective in animal osteochondral defect models. This study aimed to examine the applicability of UPAL gel implantation to acellular therapy in humans with cartilage injury.MethodsA total of 12 patients (12 knees) with symptomatic, post-traumatic, full-thickness cartilage lesions (1.0 to 4.0 cm2) were included in this study. UPAL gel was implanted into chondral defects after performing bone marrow stimulation technique, and assessed for up to t… Show more
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