Single-step scaffold-based cartilage repair in the knee: A systematic review

Fischer, Stefan; Kisser, Agnes

doi:10.1016/j.jor.2016.06.004

Cited by 13 publications

(4 citation statements)

References 13 publications

(58 reference statements)

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“…The use of scaffolds to augment knee joint preservation surgery has been more consistently described in the literature compared with the use of PRP or stem cells, mainly because scaffolds are used during advanced ACI (matrix-induced ACI, matrixassisted ACI) for the management of articular cartilage lesions. 54,[78][79][80][81][82] Meniscal repair and replacement with the use of scaffold-based technology has been described in Europe, with encouraging short-term results reported. [83][84][85][86][87][88][89][90][91][92] In general, scaffolds are categorized based on whether they incorporate cells and whether they are synthetic or biologic in origin.…”

Section: Role Of Biologic Therapymentioning

confidence: 99%

The Utility of Biologics, Osteotomy, and Cartilage Restoration in the Knee

Frank

Cotter

Strauss

et al. 2018

J Am Acad Orthop Surg

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The management of complex cartilage and meniscal pathology in young, athletic patients is extremely challenging. Joint preservation surgery is most difficult in patients with concomitant knee pathologies, including cartilage defects, meniscal deficiency, malalignment, and/or ligamentous insufficiency. Clinical decision making for these patients is further complicated by articular cartilage lesions, which often are incidental findings; therefore, treatment decisions must be based on the confirmed contribution of articular cartilage lesions to symptomatology. Surgical management of any of the aforementioned knee pathologies that is performed in isolation typically results in acceptable patient outcomes; however, concomitant procedures for the management of concomitant knee pathologies often are essential to the success of any single procedure. The use of biologic therapy as an alternative to or to augment more conventional surgical management has increased in popularity in the past decade, and indications for biologic therapy continue to evolve. Orthopaedic surgeons should understand knee joint preservation techniques, including biologic and reconstructive approaches in young, high-demand patients.

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Section: Role Of Biologic Therapymentioning

confidence: 99%

The Utility of Biologics, Osteotomy, and Cartilage Restoration in the Knee

Frank

Cotter

Strauss

et al. 2018

J Am Acad Orthop Surg

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“…By means of their mechanical properties, scaffolds can provide benefits for patients in early rehabilitation. Scaffolding is one of the most important components of tissue engineering [ 104 ]. Combined with various cartilage-related cytokines, it can be used to raise autologous stem cells to complete tissue repair status in the damaged region, including stem cells from blood, synovial fluid, synovial tissues, and cartilage.…”

Section: Regenerative Medicine In Cartilage Repairmentioning

confidence: 99%

Advances and Prospects in Stem Cells for Cartilage Regeneration

Wang

Yuan

et al. 2017

Stem Cells International

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The histological features of cartilage call attention to the fact that cartilage has a little capacity to repair itself owing to the lack of a blood supply, nerves, or lymphangion. Stem cells have emerged as a promising option in the field of cartilage tissue engineering and regenerative medicine and could lead to cartilage repair. Much research has examined cartilage regeneration utilizing stem cells. However, both the potential and the limitations of this procedure remain controversial. This review presents a summary of emerging trends with regard to using stem cells in cartilage tissue engineering and regenerative medicine. In particular, it focuses on the characterization of cartilage stem cells, the chondrogenic differentiation of stem cells, and the various strategies and approaches involving stem cells that have been used in cartilage repair and clinical studies. Based on the research into chondrocyte and stem cell technologies, this review discusses the damage and repair of cartilage and the clinical application of stem cells, with a view to increasing our systematic understanding of the application of stem cells in cartilage regeneration; additionally, several advanced strategies for cartilage repair are discussed.

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“…Auch wenn mit dieser einfachen Methode Regenerate zu erzeugen sind, so sind für deren Einsatz Limitierungen (Defektdurchmesser) gegeben, und die Ergebnisse nach solchen Operationen verschlechtern sich innerhalb eines mittelfristigen (5-jährigen) Nachbeobachtungszeitraums [28]. Daher gelten heute zellbasierte Verfahren als Methode der Wahl für die Behandlung umschriebener Knorpelschäden [29][30][31][32][33]. Zudem gibt es Hinweise darauf, dass andere Verfahren wie die AMIC möglicherweise in den nächsten Jahren zunehmend Verbreitung erlangen könnten [34,35].…”

Section: Korrekturoperationen Bei Revisionseingriffenunclassified

Koinzidenz und Therapie von Beinachsdeviationen bei degenerativen Knorpelschäden des Kniegelenks. Ergebnisse aus dem Deutschen KnorpelRegister DGOU

Spahn

Fritz²,

Albrecht

et al. 2017

Z Orthop Unfall

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This multicenter study was aimed to evaluate the coincidence of degenerative knee cartilage lesions with a varus or valgus dysalignment. Furthermore, the frequency of the combined surgery of cartilage treatments and corrective osteotomies are determined. A total of 1778 patients were included in the German CartilageRegistry (deadline 01.08.2016). In 90.6% of patients, the surgeon calculated the alignment by clinical observation. Varus or valgus conditions were measured radiologically in only 56.0%. This study describes patients who underwent treatment of degenerative cartilage lesions with a complete (clinical and radiological) determination of the alignment. The mean mechanical tibia-femur angle (Paley) (mTFA) in clinically neutral extremities was 0.2° (SD 0.6; 0 - 5), in varus cases 5,0° (SD 3.2; 0 - 15), and - 4.7° (SD - 4.0; - 15 - 0) in valgus cases. Varus dysalignment was significantly associated with cartilage lesions in the medial compartment. Valgus dysalignment more frequently occurred in knees with lateral cartilage lesions. Independently of the surgeon's choice of the method of cartilage surgery, in 72.4% of all valgus deformities a corrective osteotomy was performed. Valgus dysalignment was corrected in 50%. In about a quarter of all cases, cartilage lesions are associated with a varus (18.9%) or valgus (4.2%) dysalignment. In a number of cases, the treatment of cartilage lesions should include the addressing of these axial deviations. Still the efficacy of this procedure regarding prognosis and clinical outcome is unclear.

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Single-step scaffold-based cartilage repair in the knee: A systematic review

Cited by 13 publications

References 13 publications

The Utility of Biologics, Osteotomy, and Cartilage Restoration in the Knee

The Utility of Biologics, Osteotomy, and Cartilage Restoration in the Knee

Advances and Prospects in Stem Cells for Cartilage Regeneration

Koinzidenz und Therapie von Beinachsdeviationen bei degenerativen Knorpelschäden des Kniegelenks. Ergebnisse aus dem Deutschen KnorpelRegister DGOU

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