Single-Step Coating of Mesoporous Silica on Cetyltrimethyl Ammonium Bromide-Capped Nanoparticles

Gorelikov, Ivan; Matsuura, Naomi

doi:10.1021/nl0727415

Cited by 506 publications

(550 citation statements)

References 28 publications

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“…AuNR@mSiO 2 NPs were synthesized according to a published procedure with minor modifications. 29 The as-prepared AuNRs (40 mL) were centrifuged (9500 r, 25 min) and dispersed in water (20 mL), followed by addition of NaOH (0.1 M, 200 μL) under stirring. Then, 20% TEOS in ethanol (200 μL) was added three times at intervals of 30 min under mixing.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“Elastic” Property of Mesoporous Silica Shell: For Dynamic Surface Enhanced Raman Scattering Ability Monitoring of Growing Noble Metal Nanostructures via a Simplified Spatially Confined Growth Method

Lin

Wang

Sun

et al. 2015

ACS Appl. Mater. Interfaces

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ABSTRACT:The Raman enhancing ability of noble metal nanoparticles (NPs) is an important factor for surface enhanced Raman scattering (SERS) substrate screening, which is generally evaluated by simply mixing as-prepared NPs with Raman reporters for Raman signal measurements. This method usually leads to incredible results because of the NP surface coverage nonuniformity and reporter-induced NP aggregation. Moreover, it cannot realize in situ, continuous SERS characterization. Herein, we proposed a dynamic SERS monitoring strategy for NPs with precisely tuned structures based on a simplified spatially confined NP growth method. Gold nanorod (AuNR) seed NPs were coated with a mesoporous silica (mSiO 2 ) shell. The permeability of mSiO 2 for both reactive species and Raman reporters rendered the silver overcoating reaction and SERS indication of NP growth. Additionally, the mSiO 2 coating ensured monodisperse NP growth in a Raman reporter-rich reaction system. Moreover, "elastic" features of mSiO 2 were observed for the first time, which is crucial for holding the growing NP without breakage. This feature makes the mSiO 2 coating adhere to metal NPs throughout the growing process, providing a stable Raman reporter distribution microenvironment near the NPs and ensuring that the substrate's SERS ability comparison is accurate. Three types of NPs, i.e., core−shell Au@AgNR@mSiO 2 , Au@AuNR@mSiO 2 , and yolk−shell Au@void@AuNR@mSiO 2 NPs, were synthesized via core−shell overgrowth and galvanic replacement methods, showing the versatility of the approach. The living cell SERS labeling ability of Au@AgNR@mSiO 2 -based tags was also demonstrated. This strategy addresses the problems of multiple batch NP preparation, aggregation, and surface adsorption differentiation, which is a breakthrough for the dynamic comparison of SERS ability of metal NPs with precisely tuned structures and optical properties.

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Section: ■ Experimental Sectionmentioning

confidence: 99%

“Elastic” Property of Mesoporous Silica Shell: For Dynamic Surface Enhanced Raman Scattering Ability Monitoring of Growing Noble Metal Nanostructures via a Simplified Spatially Confined Growth Method

Lin

Wang

Sun

et al. 2015

ACS Appl. Mater. Interfaces

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“…Refs. [43][44][45]) and it has been shown that the silica coating can increase the stability of the core particles when applying bulk heating up to 260 °C [41,42]. Gautier et al [41] interpreted this shape-protecting effect of the shell on the basis of the higher melting point of silica compared to bulk gold.…”

Section: Introductionmentioning

confidence: 99%

Thermal stability of mesoporous silica-coated gold nanorods with different aspect ratios

Gergely-Fülöp

Zámbó

Deák

2014

Materials Chemistry and Physics

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The effect of different temperatures (up to 900 °C) on the morphology of mesoporous silicacoated gold nanorods was systematically investigated. Gold nanorods with different aspect ratios (AR ranging from 2.5 to 4.3) were coated with a 15 nm thick mesoporous silica shell.Silicon supported monolayers of the particles were annealed in the temperature range of 300-900 °C. The resulting changes in particle morphology were investigated using scanning electron microscopy and visible wavelength extinction spectroscopy. The silica coating generally improved the stability of the nanorods from ca. 250 °C by several hundreds degree Celsius. For nanorods with AR<3 the shape and the aspect ratio change is only moderate up to 700 °C. At 900 °C these nanorods became spherical. For nanorods with AR>3, lower stability was found as the aspect ratio decrease was more significant and they transformed into spherical particles already at 700 °C. It was confirmed by investigating empty silica shells that the observed conformal change of the shell material when annealing core/shell particles is dictated by the deformation of the core particle. This also implies that a significant mechanical stress is exerted on the shell upon core deformation. In accordance with this, for the highest aspect ratio (AR~4) nanorod the shell breaks up at 900 °C and the gold cores were partially released and coalesced into large spherical particles.

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“…24 The as-prepared AuNRs (40 mL) were centrifuged (9500 r, 25 min) and dispersed in water (20 mL), followed by addition of NaOH (0. once with ethanol (8500 r, 15 min), and then dispersed in 20 mL ethanol.…”

Section: Preparation Of Aunr@msio 2 Npsmentioning

confidence: 99%

Mesoporous titania based yolk–shell nanoparticles as multifunctional theranostic platforms for SERS imaging and chemo-photothermal treatment

et al. 2014

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Recently surface-enhanced Raman scattering (SERS) imaging guided theranostic nanoplatforms have attracted considerable attention. Herein, we developed novel yolk-shell gold nanorod@void@meso-porous titania nanoparticles (AuNR@void@mTiO 2 NPs) for simultaneous SERS imaging and chemophotothermal therapy. Our work showed three highlighted features: first, we proposed a facile and versatile "up to down" SERS labeling strategy for the drug delivery system, in which "empty carriers" were presynthesized, followed by co-loading of Raman reporters on AuNR and anti-cancer drug doxorubicin (DOX) in mTiO 2 in sequence. The acquired SERS signal was strong enough for tracking NPs at both living cells and mice levels. Second, we selected mTiO 2 as a novel drug loading material instead of the widely used mesoporous silica (mSiO 2 ). The mTiO 2 shared satisfactory drug loading and release behavior as mSiO 2 but it was chemically inert. This property not only provided a facile way to form a yolk-shell structure but also rendered it with superior structural stability in a biological system. Third, the near infrared (NIR) light absorbing property of the AuNR SERS substrate was also explored for drug release regulation and photothermal treatment. Significantly greater MCF-7 cell killing was observed when treated together with DOX-loaded NPs and NIR laser irradiation, attributable to the synergistic chemo-thermal therapeutic effect. Our results indicated the established SERS labeled yolk-shell NP as a promising theranostic platform and suggested its potential in vivo applications.

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Single-Step Coating of Mesoporous Silica on Cetyltrimethyl Ammonium Bromide-Capped Nanoparticles

Cited by 506 publications

References 28 publications

“Elastic” Property of Mesoporous Silica Shell: For Dynamic Surface Enhanced Raman Scattering Ability Monitoring of Growing Noble Metal Nanostructures via a Simplified Spatially Confined Growth Method

“Elastic” Property of Mesoporous Silica Shell: For Dynamic Surface Enhanced Raman Scattering Ability Monitoring of Growing Noble Metal Nanostructures via a Simplified Spatially Confined Growth Method

Thermal stability of mesoporous silica-coated gold nanorods with different aspect ratios

Mesoporous titania based yolk–shell nanoparticles as multifunctional theranostic platforms for SERS imaging and chemo-photothermal treatment

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