Single stage and countercurrent extraction of 5-hydroxymethylfurfural from aqueous phase systems

Sindermann, Eva C.; Holbach, Alexander; Haan, André de; Kockmann, Norbert

doi:10.1016/j.cej.2015.07.029

Cited by 45 publications

(31 citation statements)

References 35 publications

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“…Due to the efficient countercurrent extraction in the herein developed tubular reactor, over 99% of the produced 5-HMF is present in the organic phase (see Supporting Information). This is in good agreement to results reported by Sindermann et al 31 for countercurrent extraction of 5-HMF on a technical scale. We believe this is a major benefit of our concept with regard to an overall 5-HMF production process.…”

Section: Biphasic Countercurrent Reactorsupporting

confidence: 93%

Model‐based equipment design for the biphasic production of 5‐hydroxymethylfurfural in a tubular reactor

et al. 2019

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Herein, a novel concept for the acid catalyzed dehydration of fructose (FRC) to 5-hydroxymethylfurfural (5-HMF) in a biphasic tubular reactor is presented. Reaction kinetic models were developed based on experiments performed in a newly developed lab-scale autoclave that enables a decoupled investigation of singlephase reaction and 5-HMF mass transfer. Our reaction kinetic models allow an accurate description of the biphasic reaction. Subsequently, we integrate the reaction kinetic models in the model-based design of a tailored reactor unit. This reactor unit employs the concept of in-situ extraction in a countercurrent flow of a monodisperse droplet swarm within a continuous aqueous phase. From reactor calculations, we obtain a maximum 5-HMF yield of 76% at full FRC conversion.Countercurrent in-situ extraction enables over 99% 5-HMF recovery in the organic phase.

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Section: Biphasic Countercurrent Reactorsupporting

confidence: 93%

Model‐based equipment design for the biphasic production of 5‐hydroxymethylfurfural in a tubular reactor

et al. 2019

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“…primary and secondary alcohols, ketones), which has been widely studied and showed good performance in enhancing 5-HMF yield. [40][41][42][43] In the biphasic catalyzed system, the formed 5-HMF was continuously extracted from aqueous phase to organic solvent. So 5-HMF was isolated from water in a considerable extent and the rehydration side-reaction can hardly proceed.…”

Section: Introductionmentioning

confidence: 99%

Functionalized silica nanoparticles for conversion of fructose to 5-hydroxymethylfurfural

Yang

Huang

et al. 2016

Chemical Engineering Journal

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“…The stirred-pulsed DN15 extraction column was especially developed for rapid and uncomplicated investigations of continuous countercurrent extraction on a laboratory scale, e.g., for process development. The column has already been successfully applied for various separation tasks, e.g., extractive separation of enantiomers [58] or methyl esters [59][60][61]. During these investigations, high separation efficiency was achieved in the column, resulting from miniaturization and from the agitatedpulsed operating mode.…”

Section: Extraction Columnmentioning

confidence: 99%

Equipment and Separation Units for Flow Chemistry Applications and Process Development

et al. 2019

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Process development and small‐scale production gets more and more important in fine chemistry and pharmaceutical production. An equipment toolbox assists process synthesis presented in this contribution. A microfluidic calorimeter can measure kinetic and thermodynamic reaction data with commercial plate reactors. A tubular reactor coiled with 90° bends allows for long residence time with low axial dispersion, also known as coiled flow inverter (CFI). A similar setup is used for continuous‐flow cooling crystallization. Small‐scale columns with rotating internals are employed for distillation and liquid‐liquid extraction. Main emphasis will be put on automation and scale‐up in future steps.

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Single stage and countercurrent extraction of 5-hydroxymethylfurfural from aqueous phase systems

Cited by 45 publications

References 35 publications

Model‐based equipment design for the biphasic production of 5‐hydroxymethylfurfural in a tubular reactor

Model‐based equipment design for the biphasic production of 5‐hydroxymethylfurfural in a tubular reactor

Functionalized silica nanoparticles for conversion of fructose to 5-hydroxymethylfurfural

Equipment and Separation Units for Flow Chemistry Applications and Process Development

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