Single-stage acellular dermal matrix reconstruction of defects in the nose and ears with exposed cartilage: a prospective case series

Abstract

Background The treatment of soft tissue defects with exposed cartilage after tumor excision is challenging. Local flap reconstruction causes occasional scarring, especially in non-Caucasian populations. Scar treatment requires secondary procedures for aesthetic modifications. Two-step reconstruction with an acellular dermal matrix addresses this issue and yields highly acceptable aesthetic resultsWe aimed to investigate the efficacy of an artificial dermal matrix cover using one-step reconstruction for defects with cartilage exposure. Methods From July 2018 to September 2020, seven patients were enrolled and underwent a single-stage operation using acellular dermal matrices. Patients were followed up for at least 6 months and the size of the wound, days to heal, patient satisfaction, and scar scale scores were recorded. Results Patients were followed up for an average of 25.7 months. The average time to heal was 23.4 days postoperatively. No hyperpigmentation, tumor recurrence, or retraction was noted. High acceptance and satisfaction with the outcome were observed in all patients. Conclusions Single-stage reconstruction yielded high acceptance of aesthetic results similar to that in two-stage reconstruction. Less time and cost make this an effective and efficient treatment for soft tissue defects compared with traditional techniques.

Enhancing cartilage regeneration and repair through bioactive and biomechanical modification of 3D acellular dermal matrix

“…Consequently, ADM has gained substantial attention in the cartilage tissue engineering field. For instance, Lei and Huang [ 38 ] successfully employed ADM for the restoration of nasal cartilage post-tumor excision. Meanwhile, Ye et al [ 39 ] achieved a significant reparative outcome in mending articular cartilage defects in rabbit knee joints by administering orally administered naringin in conjunction with ADM.…”