Single-slice epicardial fat area measurement: do we need to measure the total epicardial fat volume?

Oyama, Noriko; Goto, Daisuke; Ito, Yoichi M.; Ishimori, Naoki; Mimura, Rie; Furumoto, Tomoo; Kato, Fumiki; Tsutsui, Hiroyuki; Tamaki, Nagara; Terae, Satoshi; Shirato, Hiroki

doi:10.1007/s11604-010-0524-z

Cited by 37 publications

(35 citation statements)

References 18 publications

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“…Oyama et al . [17] described a method of estimating the total EFV by MSCT scan, using a single MSCT slice located at the level of the LMCA. Single slice epicardial fat area (ssEFA) measured at the level of the LMCA correlated well with total EFV in this study (r = 0.92; P < 0.0001) [17].…”

Section: Methodsmentioning

confidence: 99%

“…[17] described a method of estimating the total EFV by MSCT scan, using a single MSCT slice located at the level of the LMCA. Single slice epicardial fat area (ssEFA) measured at the level of the LMCA correlated well with total EFV in this study (r = 0.92; P < 0.0001) [17]. We used a similar method as Oyama et al The EFV of two MSCT slices nearest the origin of the LMCA were measured on each patient (GE Advantage Workstation, “volume tool”).…”

Section: Methodsmentioning

confidence: 99%

“…Measurement of the total volume of epicardial fat requires radiological techniques that are time-consuming and labor-intensive in clinical settings; however, Oyama et al determined the single-slice epicardial fat area (ssEFA), measured at the level of the left main coronary artery (LMCA), provides a reliable estimate of total epicardial fat volume (EFV) [17]. In this study, we used a similar technique as Oyama et al, and measured the single slice epicardial fat volume (ssEFV) at the level of the LMCA in a cohort of stage 3–5 CKD patients, in order to test the hypothesis that coronary calcification is more severe in CKD patients with greater epicardial fat.…”

Section: Introductionmentioning

confidence: 99%

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Associations of epicardial fat with coronary calcification, insulin resistance, inflammation, and fibroblast growth factor-23 in stage 3-5 chronic kidney disease

et al. 2013

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BackgroundEpicardial fat, quantified in a single multi-slice computed tomography (MSCT) slice, is a reliable estimate of total epicardial fat volume (EFV). We sought to determine risk factors for EFV detected in a single-slice MSCT measurement (ssEFV) in pre-dialysis chronic kidney disease (CKD) patients. Our primary objective was to determine the association between ssEFV and coronary artery calcification (CAC).Methods94 pre-dialysis stage 3–5 CKD patients underwent MSCT to measure ssEFV and CAC. ssEFV was quantified at the level of the left main coronary artery. Measures of inflammation, traditional and kidney-related cardiovascular disease risk factors were collected.ResultsMean age: 63.7 ± 14 years, 56% male, 39% had diabetes, and mean eGFR: 25.1 ± 11.9 mL/min/1.73 m2. Mean ssEFV was 5.03 ± 2.4 cm3. By univariate analysis, body mass index (BMI) (r = 0.53; P = <0.0001), abdominal obesity (r = 0.51; P < 0.0001), high density lipoprotein (HDL) cholesterol (r = − 0.39; P = <0.0001), insulin resistance (log homeostasis model assessment of insulin resistance (log HOMA-IR)) (r = 0.38, P = 0.001), log interleukin-6 (IL-6) (r = 0.34; P = 0.001), and log urinary albumin to creatinine ratio (UACR) (r = 0.30, P = 0.004) demonstrated the strongest associations with ssEFV. Log coronary artery calcification (log CAC score) (r = 0.28, P = 0.006), and log fibroblast growth factor-23 (log FGF-23) (r = 0.23, P = 0.03) were also correlated with ssEFV. By linear regression, log CAC score (beta =0.40; 95% confidence interval (CI), 0.01-0.80; P = 0.045), increasing levels of IL-6 (beta = 0.99; 95% CI, 0.38 – 1.61; P = 0.002), abdominal obesity (beta = 1.86; 95% CI, 0.94 - 2.8; P < 0.0001), lower HDL cholesterol (beta = −2.30; 95% CI, – 3.68 to −0.83; P = 0.002) and albuminuria (log UACR, beta = 0.81; 95% CI, 0.2 to 1.4; P = 0.01) were risk factors for increased ssEFV.ConclusionsIn stage 3–5 CKD, coronary calcification and IL-6 and were predictors of ssEFV. Further studies are needed to clarify the mechanism by which epicardial fat may contribute to the pathogenesis of coronary disease, particularly in the CKD population.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations of epicardial fat with coronary calcification, insulin resistance, inflammation, and fibroblast growth factor-23 in stage 3-5 chronic kidney disease

et al. 2013

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“…We used maximal thickness and area of both layers as indices of total amount and groove thickness as indices of varying fat distribution. EFA is a highly reproducible index of EF quantity and is significantly correlated with EF total volume, but simpler and less prone to under or overestimation when measured manually [26]. We found that the radiodensity of both layers was related to the amount of fat, but there were no significant associations with any other ultrasound fat indices, CV risk factors, or MS.…”

Section: Epicardial (Ef) and Pericardial Fat (Pf)mentioning

confidence: 61%

Extra-media thickness and epicardial fat: Comparison of a novel carotid artery ultrasound index and a well-established cardiac magnetic resonance fat quantification method

Haberka

Sosnowski

Zuziak-Pruska

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

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“…MDCT can provide more accurate measurements than other techniques because of its high temporal resolution [1], and MDCT measurements are reproducible [2,3]. It has also been shown that MDCT volumetric measurements are more reliable than echocardiographic thickness measurements [4].…”

Section: Introductionmentioning

confidence: 99%

The relationship between location-specific epicardial adipose tissue volume and coronary atherosclerotic plaque burden in type 2 diabetic patients

et al. 2017

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A b s t r a c tBackground and aim: Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot that plays an important role in the pathogenesis of coronary atherosclerosis. Due to its asymmetrical distribution, the relation between location-specific EAT measurements and coronary atherosclerosis remains unclear. Our study investigated the relationship between location-specific EAT volume and coronary atherosclerotic plaque burden that was detected by coronary computed tomography angiography (CCTA) in type 2 diabetic patients without coronary artery disease (CAD) history. Methods:A total of 157 consecutive diabetic patients who had undergone CCTA were included retrospectively. After evaluation of the CCTA images, the study population was divided into two groups according to the presence of coronary atherosclerosis. In both groups, total and left atrioventricular groove EAT volumes were measured. Results:Total and left atrioventricular groove EAT volumes were significantly associated with coronary atherosclerosis, but only left atrioventricular groove EAT volumes were an independent predictor for CAD. Also, total and left atrioventricular groove EAT volumes were positively correlated with C-reactive protein values (p = 0.0001/p = 0.0001) and the number of coronary atherosclerotic segments (p = 0.0001/p = 0.0001).

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Single-slice epicardial fat area measurement: do we need to measure the total epicardial fat volume?

Abstract: The EFA is significantly correlated with the EFV. The EFA is a simple, quick method for representing the time-consuming EFV, which has been used as a predictive indicator of cardiovascular diseases.

Cited by 37 publications

References 18 publications

Associations of epicardial fat with coronary calcification, insulin resistance, inflammation, and fibroblast growth factor-23 in stage 3-5 chronic kidney disease

Associations of epicardial fat with coronary calcification, insulin resistance, inflammation, and fibroblast growth factor-23 in stage 3-5 chronic kidney disease

Extra-media thickness and epicardial fat: Comparison of a novel carotid artery ultrasound index and a well-established cardiac magnetic resonance fat quantification method

The relationship between location-specific epicardial adipose tissue volume and coronary atherosclerotic plaque burden in type 2 diabetic patients

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