Single-shot morpho-functional and structural characterization of the left-ventricle in a mouse model of acute ischemia-reperfusion injury with an optimized 3D IntraGate cine FLASH sequence at 7T MR

Palmisano, Anna; Piccoli, Marco; Monti, Caterina Beatrice; Canu, Tamara; Cirillo, Federica; Napolitano, Angela; Perani, Laura; Signorelli, Paola; Vignale, Davide; Anastasia, Luigi; Esposito, Antonio

doi:10.1016/j.mri.2020.01.015

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2022

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“…Cardiac functionality was measured in terms of ejection fraction (EF) and fractional shortening (FS) by echocardiography, as previously reported [ 52 ].…”

Section: Methodsmentioning

confidence: 99%

Neu3 Sialidase Activates the RISK Cardioprotective Signaling Pathway during Ischemia and Reperfusion Injury (IRI)

Piccoli

Coviello

Canali

et al. 2022

IJMS

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Coronary reperfusion strategies are life-saving approaches to restore blood flow to cardiac tissue after acute myocardial infarction (AMI). However, the sudden restoration of normal blood flow leads to ischemia and reperfusion injury (IRI), which results in cardiomyoblast death, irreversible tissue degeneration, and heart failure. The molecular mechanism of IRI is not fully understood, and there are no effective cardioprotective strategies to prevent it. In this study, we show that activation of sialidase-3, a glycohydrolytic enzyme that cleaves sialic acid residues from glycoconjugates, is cardioprotective by triggering RISK pro-survival signaling pathways. We found that overexpression of Neu3 significantly increased cardiomyoblast resistance to IRI through activation of HIF-1α and Akt/Erk signaling pathways. This raises the possibility of using Sialidase-3 activation as a cardioprotective reperfusion strategy after myocardial infarction.

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“…Cardiac functionality was measured in terms of ejection fraction (EF) and fractional shortening (FS) by echocardiography, as previously reported [ 52 ].…”

Section: Methodsmentioning

confidence: 99%