Single-scan multidimensional magnetic resonance

Tal, Assaf; Frydman, Lucio

doi:10.1016/j.pnmrs.2010.04.001

Cited by 251 publications

(226 citation statements)

References 61 publications

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“…[233] The further RD NMR development could concern utilization of such extremely longlived HP. In addition, the progress achieved in the field of singlescan ultra-fast NMR techniques [234] also offers new capabilities, which earlier were considered incompatible with NMR hyperpolarization. For example, recent work demonstrates the feasibility of single-scan 2D Laplace NMR experiments of dissolved HP propene, [235] and the method should be applicable, e.g., for the investigation of dynamics and physical environments of HP gases in porous media, both with high-field and low-field (mobile) NMR instruments.…”

Section: Outcome and Perspectivesmentioning

confidence: 99%

NMR Hyperpolarization Techniques of Gases

Barskiy

Coffey

Nikolaou

et al. 2016

Chemistry A European J

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Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4-8 orders of magnitude. Hyperpolarized gases, unlike liquids and solids, can be more readily separated and purified from the compounds used to mediate the hyperpolarization processes. These pure hyperpolarized gases enabled many novel MRI applications including the visualization of void spaces, imaging of lung function, and remote detection. Additionally, hyperpolarized gases can be dissolved in liquids and can be used as sensitive molecular probes and reporters. This mini-review covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.

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Section: Outcome and Perspectivesmentioning

confidence: 99%

NMR Hyperpolarization Techniques of Gases

Barskiy

Coffey

Nikolaou

et al. 2016

Chemistry A European J

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“…Spatiotemporal encoding relies on a manipulation involving the combined action of a frequency-swept pulse applied in the presence of an encoding gradient, followed by a sequential unraveling of the encoded imaging information using an acquisition gradient [20]. These manipulations can deliver an MR image without the use of a Fourier Transform (FT); when the encoding pulse duration is different from the acquisition duration and/or if no refocusing pulses are used, a built-in spectral encoding is also obtained [27].…”

Section: Theoretical Background Spen's Simultaneous Spatial and Spectmentioning

confidence: 99%

“…First introduced for the acquisition of 2D NMR spectra in a single scan [19,20], spatiotemporal encoding (SPEN) utilizes a chirped pulse combined with a gradient for a sequential manipulation of the spins that can directly monitor their density in real space [21,22]. In an imaging context, SPEN uses such a manipulation along the low-bandwidth domain in combination with a conventional k-space readout, leading to a so-called hybrid acquisition mode [23,24].…”

Section: Introductionmentioning

confidence: 99%

In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding

Schmidt

Laustsen

Dumez

et al. 2014

Journal of Magnetic Resonance

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Hyperpolarized metabolic imaging is a growing field that has provided a tool for analyzing metabolism, particularly in cancer. Given the short life times of the hyperpolarized signal, fast and effective spectroscopic imaging methods compatible with dynamic metabolic characterizations are necessary. Several approaches have been customized for hyperpolarized 13 C MRI, including CSI with a center-out k-space encoding, EPSI, and spectrally selective pulses in combination with spiral EPI acquisitions. Recent studies have described the potential of single-shot alternatives based on spatiotemporal encoding (SPEN) principles, to derive chemical-shift images within a sub-second period. By contrast to EPSI, SPEN does not require oscillating acquisition gradients to deliver chemical-shift information: its signal encodes both spatial as well as chemical shift information, at no extra cost in experimental complexity. SPEN MRI sequences with sliceselection and arbitrary excitation pulses can also be devised, endowing SPEN with the potential to deliver single-shot multi-slice chemical shift images, with a temporal resolution required for hyperpolarized dynamic metabolic imaging. The present work demonstrates this with initial in vivo results obtained from SPEN-based imaging of pyruvate and its metabolic products, after injection of hyperpolarized [1-13 C]pyruvate. Multi-slice chemical-shift images of healthy rats were obtained at 4.7 T in the region of the kidney, and 4D (2D spatial, 1D spectral, 1D temporal) data sets were obtained at 7 T from a murine lymphoma tumor model.

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“…5 In the UF-NMR approach, the usual t 1 encoding is replaced by spatial encoding, and after a conventional mixing period, the spatially encoded information is decoded by a detection block based on echo planar imaging (EPI). 7 The principles of UF-NMR have been extensively described in recent reviews [14][15][16] and are summarized below. The spatial encoding scheme initially proposed by Frydman 13,17 relies on a succession of frequency-selective pulses applied during alternating bipolar gradient pairs.…”

Section: Introductionmentioning

confidence: 99%

Optimization and practical implementation of ultrafast 2D NMR experiments

Júnior¹,

Ferreira²,

Giraudeau³

2013

Quím. Nova

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Recebido em 30/4/12; aceito em 17/10/12; publicado na web em 8/3/13 Ultrafast 2D NMR is a powerful methodology that allows recording of a 2D NMR spectrum in a fraction of second. However, due to the numerous non-conventional parameters involved in this methodology its implementation is no trivial task. Here, an optimized experimental protocol is carefully described to ensure efficient implementation of ultrafast NMR. The ultrafast spectra resulting from this implementation are presented based on the example of two widely used 2D NMR experiments, COSY and HSQC, obtained in 0.2 s and 41 s, respectively.

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Single-scan multidimensional magnetic resonance

Cited by 251 publications

References 61 publications

NMR Hyperpolarization Techniques of Gases

NMR Hyperpolarization Techniques of Gases

In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding

Optimization and practical implementation of ultrafast 2D NMR experiments

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