A novel Multiple-Input and Multiple-Output (MIMO) transmission scheme termed as Generalized Quadrature Spatial Modulation (G-QSM) is proposed. It amalgamates the concept of Quadrature Spatial Modulation (QSM) and spatial multiplexing for the sake of achieving a high throughput, despite relying on low number of Radio Frequency (RF) chains. In the proposed G-QSM scheme, the conventional constellation points of the spatial multiplexing structure are replaced by the QSM symbols, hence the information bits are conveyed both by the antenna indices as well as by the classic Amplitude/Phase Modulated (APM) constellation points. The upper bounds of the Average Bit Error Probability (ABEP) of the proposed G-QSM system in high throughput massive MIMO configurations are derived. Furthermore, an Efficient Multipath Orthogonal Matching Pursuit (EM-OMP) based Compressive Sensing (CS) detector is developed for our proposed G-QSM system. Both our analytical and simulation results demonstrated that the proposed scheme is capable of providing considerable performance gains over the existing schemes in massive MIMO configurations.