Single pulse electrical stimulation and high-frequency oscillations, a complicated marriage

Valentı́n, Antonio; Alarcón, Gonzalo

doi:10.1016/j.clinph.2017.02.013

Cited by 1 publication

(1 citation statement)

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“…Thus, a CCSR HG induced by SPES reflects changes in neuronal firing rates elicited by simulated external input, via direct or indirect anatomical connections with the stimulation site [9,[20][21][22][23][24][25][26]. CCSR HG generator mechanisms are still debated [27], but the changes in neural behavior reported in stimulation studies with single unit recordings or dye imaging are similar to those of CCSR HG [28][29][30]. Because SPES is task-free and does not require patient cooperation, CCEP and CCSR recorded by SPES can be used to study how sleep alters the dynamic characteristics of human brain networks.…”

Section: Introductionmentioning

confidence: 99%

The neural tides of sleep and consciousness revealed by single-pulse electrical brain stimulation

Usami

Korzeniewska

Matsumoto

et al. 2019

Sleep

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Wakefulness and sleep arise from global changes in brain physiology that may also govern the flow of neural activity between cortical regions responsible for perceptual processing versus planning and action. To test whether and how the sleep/wake cycle affects the overall propagation of neural activity in large-scale brain networks, we applied single-pulse electrical stimulation (SPES) in patients implanted with intracranial EEG electrodes for epilepsy surgery. SPES elicited corticocortical spectral responses at high-gamma frequencies (CCSR HG , 80-150 Hz), which indexes changes in neuronal population firing rates. Using event-related causality (ERC) analysis, we found that the overall patterns of neural propagation among sites with CCSR HG were different during wakefulness and different sleep stages. For example, stimulation of frontal lobe elicited greater propagation toward parietal lobe during slow-wave sleep than during wakefulness. During REM sleep, we observed a decrease in propagation within frontal lobe, and an increase in propagation within parietal lobe, elicited by frontal and parietal stimulation, respectively. These biases in the directionality of large-scale cortical network dynamics during REM sleep could potentially account for some of the unique experiential aspects of this sleep stage. Together these findings suggest that the regulation of conscious awareness and sleep is associated with differences in the balance of neural propagation across large-scale frontal-parietal networks.

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