Single Port Laparoscopic Cholecystectomy in Hue Central Hospital

Pham, Xuan Dong; Pham, Nhu Hiep; Ho, Huu Thien; Phạm, Anh Vũ; Nguyen, Hang; Nguyễn, Thanh Xuân

doi:10.34071/jmp.2012.2.4

Cited by 3 publications

(3 citation statements)

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“…The study assessed the effects of coffee on the brain among 17,702 UK Biobank participants aged 37-73. [11] 'Drinking coffee in moderation is associated with a lower risk of dementia, but the highest risk of dementia is associated with heavy coffee consumption,' said team member David Llewellyn, Professor of Epidemiology and Digital Health at the University of Exeter, UK. 'We found that drinking more than six cups of coffee/day was associated with 53% increase in dementia risk in comparison with people drinking one or two cups/day.…”

Section: Role Of Caffeinementioning

confidence: 99%

Waking up to Coffee

2023

Chemistry & Industry

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Section: Role Of Caffeinementioning

confidence: 99%

Waking up to Coffee

2023

Chemistry & Industry

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“…Figure 1A shows the increasing trend in primary bile acids, while Figure 1B presents the declining trend in 3-oxo-D4 bile acids in three patients. Pham et al Medicine (2022) 101:25 Medicine symptoms and signs. After 6 months of treatment, all laboratory tests were within normal ranges (Table 1).…”

Section: Patientmentioning

confidence: 99%

Clinical and genetic features of congenital bile acid synthesis defect with a novel mutation in AKR1D1 gene sequencing

Pham

Thi

et al. 2022

Medicine

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Rationale:Congenital bile acid synthesis defect (BASD) is a rare disease caused by mutations in the aldo-keto reductase 1D1 gene, which encodes the primary Δ4-3-oxosteroid 5β-reductase enzyme. Early disease diagnosis is critical for early treatment with bile acid replacement therapy, with an excellent chance for recovery. In contrast, protracted diagnosis and treatment may lead to poor outcomes, including decompensated hepatic cirrhosis, liver transplant, and even death.Patient concerns:Three clinical congenital bile acid synthesis defect cases in the Vietnamese population are herein reported. These pediatric patients presented with symptoms of prolonged postpartum jaundice and abnormal loose stool (mucus, lipids, and white). The clinical examinations showed hepatosplenomegaly. Urinalysis showed a very low fraction of primary bile acids and atypical 3-oxo-Δ4- bile acids in all three patients.Diagnoses:The patients were diagnosed with primary Δ4-3-oxosteroid 5β-reductase deficiency. Next-generation gene sequencing revealed two homozygous mutations in the aldo-keto reductase family 1 member D1 gene. The first is a documented variant, c.797G>A (p.Arg266Gln), and the second is a novel mutation at c.155T>C (p.Ile52Thr).Interventions:Immediately after diagnosis, patients were treated with oral chenodeoxycholate 5 mg/kg/d.Outcomes:The patients’ symptoms, signs, and primary bile acids levels improved significantly.Lessons:Clinicians should consider genetic disorders related to cholestasis for effective and life-saving treatment. A prompt genetic analysis by next-generation gene sequencing enables patients to access bile acid replacement therapy earlier, significantly improving short- and long-term outcomes.

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“…This parylene layer is removed over the landing metal at bottom of the via by dry etching in an oxygen plasma. The patterning is achieved by spray coating of photoresist where a special process with heated chuck is developed for improved corner coverage [3]. The Ti/Cu seed layer is then deposited for the consecutive electroplating of 5-20µm thick Cu layer which serves as the main conductive path between the silicon wafer front and back.…”

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confidence: 99%