Single-port glucose monitoring with simultaneous insulin infusion

Abstract

We present a novel single-port continuous glucose monitoring system that simultaneously performs continuous glucose monitoring in subcutaneous tissue and insulin infusion. The luminescence based glucose sensor is applied on commercial insulin infusion catheters and is read-out transcutaneously by an optical module attached to the skin. In-vitro and in-vivo evaluation results demonstrate a good proof of concept with median absolute relative error values in the range of 20%.

Can Glucose Be Monitored Accurately at the Site of Subcutaneous Insulin Delivery?

“…Mean absolute relative errors, which typically are greater than median values, were not reported; the degree of error for the 3 conditions was higher than with other previously published methods. 15 We are aware of only 1 study that evaluated how the proximity of the insulin injection site relative to nondialysis amperometric sensors influenced local glucose levels. In this study, Rodriguez et al compared the effect of sensors placed as close as 5 mm to insulin injection sites ("near sensors") to sensors at greater distances ("far sensors").…”

“…Using this method, the ISF glucose levels were quite similar to those obtained from blood, suggesting that delivery of insulin at the glucose sampling site did not lead to systematic error. 14 In a very recent study, Hajnsek et al 15 also studied a catheter designed both for insulin delivery and for continuous measurement of glucose in SC tissue. The sensing chemistry included a glucose oxidase-bound layer of a luminescent dye.…”

“…In a very recent study, Hajnsek et al 15 also studied a catheter designed both for insulin delivery and for continuous measurement of glucose in SC tissue. The sensing chemistry included a glucose oxidase-bound layer of a luminescent dye.…”

“…Mean absolute relative errors, which typically are greater than median values, were not reported; the degree of error for the 3 conditions was higher than with other previously published methods. 15…”