Single‐Pore Membranes Gated by Microelectromagnetic Traps

Basore, Joseph R.; Lavrik, Nickolay V.; Baker, Lane A.

doi:10.1002/adma.201000566

Cited by 13 publications

(13 citation statements)

References 58 publications

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“…The transport of biopolymers through nanoscale channels is of relevance in nanopore analytics, nanofiltration, 1 and biology. In nanopore analytics, single molecules are detected via the passage-induced changes in ionic current.…”

Section: Introductionmentioning

confidence: 99%

Disentangling Steric and Electrostatic Factors in Nanoscale Transport Through Confined Space

et al. 2013

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The voltage-driven passage of biological polymers through nanoscale pores is an analytically, technologically, and biologically relevant process. Despite various studies on homopolymer translocation there are still several open questions on the fundamental aspects of the pore transport. One of the most important unresolved issues revolves around the passage of biopolymers which vary in charge and volume along their sequence. Here we exploit an experimentally tunable system to disentangle and quantify electrostatic and steric factors. This new, fundamental framework facilitates the understanding of how complex biopolymers are transported through confined space and indicates how biopolymer translocation can be slowed down to enable future sensing methods.SYNOPSIS: The voltage-driven translocation of complex biopolymers through a protein nanopore is biophysically modeled to disentangle and quantify electrostatic and steric factors which can oppose electrophoretic movement.

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Section: Introductionmentioning

confidence: 99%

Disentangling Steric and Electrostatic Factors in Nanoscale Transport Through Confined Space

et al. 2013

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“…The system has decoupled the parameters of magnetic field strength and gradient, and thus the two components can be separately controlled to produce magnetic forces with various distribution modes. The system has been developed for attractive and repulsive forces by switching the direction of current flow in a single micro-electromagnet, 118,119 and the manipulation strategy can be well used for micromixing without multiple micro-electromagnets in the work of Suzuki et al 103 It should be interesting to further consider the interaction between the external and internal magnetic fields to investigate the effects of the external magnetic field direction and the geometry configurations of micro-electromagnets on the dynamic behavior of magnetic particles.…”

Section: Discussionmentioning

confidence: 99%

“…The second feature is very interesting and important for manipulating magnetic particles in microfluidic systems. Take the micro-electromagnetic ring for example; it has been reported that the magnetic particles can be trapped into and repelled out of the center of the ring by changing the currents in the micro-electromagnet with a uniform external magnetic field, 118,119 which neither an external magnet system nor an internal magnet systems can do.…”

Section: Hybrid Magnet Systemmentioning

confidence: 99%

Configurations and control of magnetic fields for manipulating magnetic particles in microfluidic applications: magnet systems and manipulation mechanisms

2014

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The use of a magnetic field for manipulating the motion of magnetic particles in microchannels has attracted increasing attention in microfluidic applications. Generation of a flexible and controllable magnetic field plays a crucial role in making better use of the particle manipulation technology. Recent advances in the development of magnet systems and magnetic field control methods have shown that it has great potential for effective and accurate manipulation of particles in microfluidic systems. Starting with the analysis of magnetic forces acting on the particles, this review gives the configurations and evaluations of three main types of magnet system proposed in microfluidic applications. The interaction mechanisms of magnetic particles with magnetic fields are also discussed.

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“…This showed that two identical DNA molecules tethered between the MPs could be Reversible blockage of ion current Magnetic microvalves have been developed to externally control transport within microfluidic channels [70,71]. A simple method of controlling transport through microscopic structures with METs was developed by Basore et al [29,30]. Single-coil METs with a micropore in the center of the trap were fabricated on silicon and used to reversibly gate ionic transport with a droplet of ferrofluid.…”

Section: Dna Manipulationmentioning

confidence: 99%

“…Addition of an external magnetic field can generate attractive and repulsive forces that depend on the direction of current flow through the METs. This is extremely useful for manipulation of MPs at multiple locations with a single MET or over long distances with multiple METs [29][30][31][32][33][34][35][36]. Attractive and repulsive forces are created by coupling between magnetic fields of the METs and the external magnet.…”

Section: Effect Of An External Magnetic Fieldmentioning

confidence: 99%

Applications of microelectromagnetic traps

Basore

Baker

2012

Anal Bioanal Chem

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Microelectromagnetic traps (METs) have been used for almost two decades to manipulate magnetic fields. Different trap geometries have been shown to produce distinct magnetic fields and field gradients. Initially, microelectromagnetic traps were used mainly to separate and concentrate magnetic material at small scales. Recently such traps have been implemented for unique applications, for example filterless bioseparations, inductive heat generation, and biological detection. In this review, we describe recent reports in which MET geometry, current density, or external fields have been used. Descriptions of recent applications in which METs have been used to develop sensors, manipulate DNA, or block ion current are also provided.

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Single‐Pore Membranes Gated by Microelectromagnetic Traps

Cited by 13 publications

References 58 publications

Disentangling Steric and Electrostatic Factors in Nanoscale Transport Through Confined Space

Disentangling Steric and Electrostatic Factors in Nanoscale Transport Through Confined Space

Configurations and control of magnetic fields for manipulating magnetic particles in microfluidic applications: magnet systems and manipulation mechanisms

Applications of microelectromagnetic traps

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