Single photon emission tomography using 99mTc-HM-PAO in the investigation of dementia.

Neary, David; Snowden, Julie S.; Shields, R. A.; Burjan, A. W. I.; Northen, B; Macdermott, N.; Prescott, M. C.; Testa, H. J.

doi:10.1136/jnnp.50.9.1101

Cited by 234 publications

(116 citation statements)

References 31 publications

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“…The instrument, which has been previously described, 26 bears some similarities to the CAMDEX, 27 although it emphasises the qualitative analysis of patients' performance, such as error type and behaviour during testing, in addition to accuracy scores. Cognitive profiles elicited by the instrument show a strong relation to findings on functional imaging, 16 and in conjunction with historical and neurological data have yielded a 97% accuracy of clinical diagnosis in 200 pathologically verified cases of dementia in this centre.…”

Section: Methods Of Evaluationmentioning

confidence: 68%

Qualitative performance characteristics differentiate dementia with Lewy bodies and Alzheimer's disease

Doubleday

Snowden²,

Varma³

et al. 2002

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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Objectives: To determine whether dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) can be differentiated on the basis of qualitative performance characteristics during neuropsychological evaluation. Methods: Forty one patients with clinically defined DLB were matched with 26 patients with AD for age, illness duration, nature and severity of cognitive deficits, and regional blood flow distribution on SPECT. The presence or absence of a set of qualitative performance characteristics, observed and recorded during the patients' initial cognitive evaluation, was identified by retrospective analysis of patients' records and the groups compared. Results: Inattention, visual distractibility, impairments in establishing and shifting mental set, incoherence, confabulatory responses, perseveration, and intrusions were significantly more common in DLB than AD. Intrusions were particularly common in DLB, occurring in 78% of the group. They included externally cued intrusions arising from the visual environment, a feature never seen in AD. In a stepwise logistic regression analysis impaired mental set shifting, perseveration, and the presence of intrusions correctly classified 79% of patients. Conclusion: It is possible to differentiate DLB and AD on the basis of qualitative features of performance. As many features are amenable to detection at clinical interview, they ought to contribute to clinicians' diagnostic armoury, leading to improved clinical recognition of DLB.

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Section: Methods Of Evaluationmentioning

confidence: 68%

Qualitative performance characteristics differentiate dementia with Lewy bodies and Alzheimer's disease

Doubleday

Snowden²,

Varma³

et al. 2002

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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“…Cerebral blood flow was measure in both patient groups using single-photon emission computed tomography (SPECT). Five of the six FTD patients showed frontal temporal hypoperfusion, and eight of the nine AD patients showed posterior hypoperfusion patterns consistent with AD (Neary et al, 1987).…”

Section: Participantsmentioning

confidence: 82%

Impaired recognition of negative facial emotions in patients with frontotemporal dementia

2005

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Patients with behavioral variant of frontotemporal dementia (FTD) have difficulties recognizing facial emotions, a deficit that may contribute to their impaired social skills. In three experiments, we investigated the FTD deficit in recognition of facial emotions, by comparing six patients with impaired social conduct, nine Alzheimer's patients, and 10 age-matched healthy adults. Experiment 1 revealed that FTD patients were impaired in the recognition of negative facial emotions. Experiment 2 replicated these findings when participants had to determine whether two faces were expressing the same or different emotions. Experiment 3 was a control study in which participants had to discriminate whether two faces were of the same sex. In this non-emotional processing task, both patient groups performed worse than normal participants, but FTD patients performed as well as Alzheimer's patients. We conclude that FTD patients are impaired in the recognition of negative facial emotions.

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“…Functional neuroimaging studies of AD and FTD patients have documented distinct abnormalities, with AD patients showing bilateral posterior temporal-parietal hypometabolism (Duara et al, 1991) and hypoperfusion (Neary et al, 1987), but relative sparing of more anterior areas. Patients with FTD display bilateral frontal and anterior temporal hypoperfusion with relatively normal parietal and occipital blood flow (Neary etal., 1988;Miller et al, 1991;Risberg et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

“…Hagberg, 1989) but not others (Jagustetal., 1989;Miller etal., 1991), while attentional losses have been observed by some investigators (Neary et al, 1986), but not others (Miller et al, 1991). Similarly, evidence for (Jagust et al, 1989;Johansen & Hagberg, 1989) and against (Neary etal., 1986;Miller etal., 1991) the presence of decreased constructional skill, and for (Neary et al, 1987;Jagust et al, 1989) and against (Miller et al, 1991) language (i.e., confrontational naming) disturbance in FTD has also emerged. In the present study, FTD patients showed significant impairments in constructional skill and free recall relative to controls, while attention and confrontation naming were spared.…”

Section: Discussionmentioning

confidence: 99%

Comparison of neuropsychological functioning in Alzheimer's disease and frontotemporal dementia

Pachana

Boone

Miller

et al. 1996

J Int Neuropsychol Soc

142

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Neuropsychological changes distinguishing mild Alzheimer's disease (AD) from frontotemporal dementia (FTD) have been described, but empirical verification of differential cognitive characteristics is lacking. Archival neuropsychological data on 15 FTD patients, 16 AD patients, and 16 controls were compared. Controls outperformed both patient groups on measures of verbal and nonverbal memory, executive ability, and constructional skill, with AD patients showing more widespread memory decline. No differences were found between the 3 groups in confrontation naming, recognition memory, or basic attention. Patient groups differed only •n nonverbal memory, with FTD patients performing significantly better than AD patients. However, patient groups also differed in pattern of performance across executive and memory domains. Specifically, AD patients exhibited significantly greater impairment on memory than executive tasks, whereas the opposite pattern characterized the rTD group. These findings suggest that examination of relative rankings of scores across cognitive domains, in addition to interpretation of individual neuropsychological scores, may be useful in differential diagnosis of FTD versus AD. (JINS, 1996, 2, 505-510.)

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Single photon emission tomography using 99mTc-HM-PAO in the investigation of dementia.

Cited by 234 publications

References 31 publications

Qualitative performance characteristics differentiate dementia with Lewy bodies and Alzheimer's disease

Qualitative performance characteristics differentiate dementia with Lewy bodies and Alzheimer's disease

Impaired recognition of negative facial emotions in patients with frontotemporal dementia

Comparison of neuropsychological functioning in Alzheimer's disease and frontotemporal dementia

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