Single photon emission computed tomography experience with (<i>S</i>)‐5‐[<sup>123</sup>I]iodo‐3‐(2‐azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokers

Brašić, James Robert; Zhou, Yun; Musachio, John L.; Hilton, John; Fan, Hong; Crabb, Andrew; Endres, Christopher J.; Reinhardt, Melvin J.; Doğan, Ahmet; Alexander, Mohab; Rousset, Olivier; Maris, Marika; Galecki, Jeffrey; Nandi, Ayon; Wong, Dean F.

doi:10.1002/syn.20611

Cited by 22 publications

(18 citation statements)

References 91 publications

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“…A T1-weighted SPGR (spoiled grass sequence; TR = 2110 ms, TE = 2.7 ms, 0.8 mm cubic voxels) covering the whole brain was used to define volumes of interest (VOIs) for the PET scan analysis; other T1- and T2-weighted images were also acquired as a part of a standardized battery (Brant-Zawadzki et al, 1992; Brašić et al, 2009) and were used to verify that participants met inclusion and exclusion criteria in the present study.…”

Section: Methodsmentioning

confidence: 99%

Linking dopaminergic reward signals to the development of attentional bias: A positron emission tomographic study

et al. 2017

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The attention system is shaped by reward history, such that learned reward cues involuntarily draw attention. Recent research has begun to uncover the neural mechanisms by which learned reward cues compete for attention, implicating dopamine (DA) signaling within the dorsal striatum. How these elevated priority signals develop in the brain during the course of learning is less well understood, as is the relationship between value-based attention and the experience of reward during learning. We hypothesized that the magnitude of the striatal DA response to reward during learning contributes to the development of a learned attentional bias towards the cue that predicted it, and examined this hypothesis using positron emission tomography with [11C]raclopride. We measured changes in dopamine release for rewarded versus unrewarded visual search for color-defined targets as indicated by the density and distribution of the available D2/D3 receptors. We then tested for correlations of individual differences in this measure of reward-related DA release to individual differences in the degree to which previously reward-associated but currently task-irrelevant stimuli impair performance in an attention task (i.e., value-driven attentional bias), revealing a significant relationship in the right anterior caudate. The degree to which reward-related DA release was right hemisphere lateralized was also predictive of later attentional bias. Our findings provide support for the hypothesis that value-driven attentional bias can be predicted from reward-related DA release during learning.

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Section: Methodsmentioning

confidence: 99%

Linking dopaminergic reward signals to the development of attentional bias: A positron emission tomographic study

et al. 2017

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“…Up-regulation can be achieved in animals by means of administration routes that are different from those of smokers and/or as nicotine doses that are much higher. Yet, it has been shown that smokers have higher cortical levels of nicotinic agonist binding and α4 subunit than non-smokers [121,122]. As the level of up-regulated subtypes persists for days after nicotine administration is stopped, it is possible that nAChR up-regulation plays a role during nicotine withdrawal.…”

Section: Regulation Of Native Subtypes By Chronic Nicotine Exposurementioning

confidence: 99%

Structural and functional diversity of native brain neuronal nicotinic receptors

Gotti

Clementi

Fornari

et al. 2009

Biochemical Pharmacology

421

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A c c e p t e d M a n u s c r i p t 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 Although some of the neural circuits involved in the acute and chronic effects of nicotine have been identified, much less is known about which native nAChR subtypes are involved in specific physiological functions and pathophysiological conditions.We briefly review some recent findings concerning the structure and function of native nAChRs, focusing on the subtypes identified in the meso-striatal and habenulo-interpeduncular pathways, two systems involved in nicotine reinforcement and withdrawal. We also discuss recent findings concerning the effect of chronic nicotine on the expression of native subtypes.

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“…Dynamic PET scans were performed over 90 minutes in a 3D mode with a GE Advance PET scanner following an IV bolus injection of 740 megabecquerels (MBq) [20 millicuries (20 mCi)] [ 11 C]MP. Three series of structural MRIs of the brain without contrast were performed 27 on a GE 1.5 T Signa MRI scanner. PET images were reconstructed using the back projection algorithm with a ramp filter using the software provided by the manufacturer correcting for attenuation, scatter, and dead-time.…”

Section: Methodsmentioning

confidence: 99%

GM1 ganglioside in Parkinson's disease: Pilot study of effects on dopamine transporter binding

Schneider

Cambi

Gollomp

et al. 2015

Journal of the Neurological Sciences

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Objective GM1 ganglioside has been suggested as a treatment for Parkinson’s disease (PD), potentially having symptomatic and disease modifying effects. The current pilot imaging study was performed to examine effects of GM1 on dopamine transporter binding, as a surrogate measure of disease progression, studied longitudinally. Methods Positron emission tomography (PET) imaging data were obtained from a subset of subjects enrolled in a delayed start clinical trial of GM1 in PD1: 15 Early-start (ES) subjects, 14 Delayed-start (DS) subjects, and 11 Comparison (standard-of-care) subjects. Treatment subjects were studied over a 2.5 year period while Comparison subjects were studied over 2 years. Dynamic PET scans were performed over 90 minutes following injection of [11C]methylphenidate. Regional values of binding potential (BPND) were analyzed for several striatal volumes of interest. Results Clinical results for this subset of subjects were similar to those previously reported for the larger study group. ES subjects showed early symptomatic improvement and slow symptom progression over the study period. DS and Comparison subjects were initially on the same symptom progression trajectory but diverged once DS subjects received GM1 treatment. Imaging results showed significant slowing of BPND loss in several striatal regions in GM1-treated subjects and in some cases, an increased BPND in some striatal regions was detected after GM1 use. Interpretation Results of this pilot imaging study provide additional data to suggest a potential disease modifying effect of GM1 on PD. These results need to be confirmed in a larger number of subjects.

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Single photon emission computed tomography experience with (S)‐5‐[¹²³I]iodo‐3‐(2‐azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokers

Cited by 22 publications

References 91 publications

Linking dopaminergic reward signals to the development of attentional bias: A positron emission tomographic study

Linking dopaminergic reward signals to the development of attentional bias: A positron emission tomographic study

Structural and functional diversity of native brain neuronal nicotinic receptors

GM1 ganglioside in Parkinson's disease: Pilot study of effects on dopamine transporter binding

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Single photon emission computed tomography experience with (S)‐5‐[123I]iodo‐3‐(2‐azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokers

Cited by 22 publications

References 91 publications

Linking dopaminergic reward signals to the development of attentional bias: A positron emission tomographic study

Linking dopaminergic reward signals to the development of attentional bias: A positron emission tomographic study

Structural and functional diversity of native brain neuronal nicotinic receptors

GM1 ganglioside in Parkinson's disease: Pilot study of effects on dopamine transporter binding

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Product

Resources

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Single photon emission computed tomography experience with (S)‐5‐[¹²³I]iodo‐3‐(2‐azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokers