Single-photon emission computed tomography/computed tomography for evaluation of salivary gland dysfunction: preliminary study on diagnostic ability of maximum standardized uptake value

Ninomiya, Kazunori; Toya, Shuji; Ogura, Ichiro

doi:10.1007/s11282-019-00393-2

Cited by 11 publications

(12 citation statements)

References 11 publications

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“…Therefore, SPECT/CT images are more suitable than planar images for evaluating the precise location of the TGs, which are small, thin, and predominantly overlaying the tori tubarius [1]. Although SPECT/CT scans have been recently performed in salivary gland scintigraphy in some institutions [9], we do not routinely perform SPECT/CT in salivary gland scintigraphy. On the other hand, evaluating thyroid tumors is a good indication of SPECT/CT scans with [ 99m Tc] pertechnetate [10,11].…”

Section: Introductionmentioning

confidence: 99%

Can the function of the tubarial glands be evaluated using [99mTc]pertechnetate SPECT/CT, [18F]FDG PET/CT, and [11C]methionine PET/CT?

et al. 2021

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Background The tubarial glands (TGs) are recently reported as newly found salivary gland structures that can be organs at risk predominantly localized in the tori tubarius in the nasopharynx using prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT). The aims of this study were to analyze uptake in the TGs compared with that in the other salivary glands and palatine tonsils using [99mTc]pertechnetate SPECT/CT, [18F]FDG PET/CT, and [11C]methionine PET/CT and to confirm whether these three imaging modalities are useful in evaluating the physiological function of the TGs. Twelve and 130 patients, who underwent [99mTc]pertechnetate SPECT/CT and [18F]FDG/[11C]methionine PET/CT, respectively, were retrospectively included. [99mTc]pertechnetate uptake in the tori tubarius was visually assessed and semiquantitatively compared with that in the background, parotid salivary glands (PSGs), submandibular salivary glands (SmSGs), and sublingual salivary glands (SlSGs). Correlations of [18F]FDG and [11C]methionine uptakes in the tori tubarius with those in the other three salivary glands and palatine tonsils were analyzed. Results [99mTc]pertechnetate uptake in the tori tubarius was invisible and was not significantly higher than that in the background. Both [18F]FDG and [11C]methionine uptakes in the tori tubarius were correlated with that in the palatine tonsils (r = 0.56, p < 0.0001; r = 0.48, p < 0.0001, respectively). [18F]FDG uptake in the tori tubarius was not positively correlated with that in the PSGs, SmSGs, and SlSGs (r = − 0.19, p = 0.03; r = − 0.02, p = 0.81; r = 0.12, p = 0.17, respectively). [11C]methionine uptake in the tori tubarius was correlated with that in the SmSGs and SlSGs (r = 0.24, p = 0.01; r = 0.32, p < 0.01, respectively), but not with that in the PSGs (r = 0.16, p = 0.08). Conclusions The TGs were undetectable on [99mTc]pertechnetate SPECT/CT. Both [18F]FDG and [11C]methionine uptakes in the tori tubarius were clearly affected by that in the palatine tonsils and was little related to that in the other salivary glands. Therefore, it seems difficult to evaluate the physiological function of the TGs as salivary glands using [99mTc]pertechnetate SPECT/CT, [18F]FDG PET/CT, and [11C]methionine PET/CT imaging.

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Section: Introductionmentioning

confidence: 99%

Can the function of the tubarial glands be evaluated using [99mTc]pertechnetate SPECT/CT, [18F]FDG PET/CT, and [11C]methionine PET/CT?

et al. 2021

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“…Quantitative SPECT/CT offers the possibility to continue and expand the potential of quantitative nuclear medicine applications [9,10]. Quantitative salivary gland SPECT/CT holds promise as an objective imaging modality for assessment of salivary dysfunction [11][12][13]. Furthermore, SUV using Q.Metrix [14,15] and GI-BONE [16][17][18][19] software could be useful for the evaluation of jaw lesions.…”

Section: Introductionmentioning

confidence: 99%

Volumetric analysis of mandibular lesions with SPECT/CT: a pilot clinical study of maximum standardized uptake value

Minami¹,

Ogawa²,

Ogura³

2022

Pol J Radiol

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Purpose This study was designed to investigate mandibular lesions using volumetric analysis with bone single-photon emission computed tomography/computed tomography (SPECT/CT). Material and methods Eight patients with mandibular lesions underwent SPECT/CT scan acquisition 4 hours after injection of Tc-99m hydroxymethylene diphosphonate (HMDP). Regarding volumetric analysis, maximum standar-dized uptake value (SUV) was obtained using software and a workstation (Q.Volumetrix MI and GEniE-Xeleris 4 DR, respectively). The localization and size of the volume of interest (VOI) can be drawn over the lesion, mesial, distal, and opposite side as normal using the CT, SPECT, and SPECT/CT transaxials, coronals, and sagittals as the anatomical reference. Q.Volumetrix MI can analyse SUV of lesions by organ segmentation using optional pan and zoom imaging. Then, the dosimetry software provided multiple quantitative data for a given VOI. Statistical analyses for the maximum SUV were performed by Mann-Whitney U test. A p -value lower than 0.05 was considered as statistically significant. Results Maximum SUVs for medication-related osteonecrosis of the jaw ( n = 4, 25.4 ± 4.9), chronic osteomyelitis ( n = 3, 14.6 ± 3.1), and squamous cell carcinoma ( n = 1, 31.7) were significantly higher than those of the opposite side as normal mandible (3.8 ± 0.7, 4.6 ± 1.8, and 7.4, respectively; p = 0.000). Conclusions Volumetric analysis with SPECT/CT could be useful for the evaluation of mandibular lesions, such as detecting and surgical planning.

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“…SUV is defined as the tissue concentration of tracer as measured by a scanner divided by the activity injected divided usually by body weight [14]. Quantitative salivary gland SPECT-CT holds promise as an objective imaging modality for assessment of salivary dysfunction [15,16]. Furthermore, SUV derived from bone SPECT-CT could be useful for the evaluation of osteonecrosis of the jaw [17,18].…”

Section: Introductionmentioning

confidence: 99%

Gallium-67 SPECT-CT for the evaluation of head and neck: preliminary study on maximum standardised uptake value in lesions, and in the parotid and submandibular glands

Oohashi¹,

Toshima²,

Hayama³

et al. 2020

Pol J Radiol

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The aim of this study was to investigate the gallium-67 ( 67 Ga) single-photon emission-computed tomography (SPECT-CT) for the evaluation of head and neck, especially maximum standardised uptake value (SUV max ) in lesions, and in the parotid and submandibular glands. Material and methods:Fourteen patients with head and neck lesions who underwent SPECT-CT at 72 hours after injection of 67 Ga were included in this study. The 67 Ga SPECT-CT parameters SUV max were compared between the parotid glands and submandibular glands. Statistical analyses for the SUV max were performed by Mann-Whitney U test. A p value lower than 0.05 was considered as statistically significant.Results: Of all 14 patients, 67 Ga SPECT-CT was positive for two cases (one malignant lymphoma and one osteomyelitis). The SUV max for malignant lymphoma and osteomyelitis were 11.21 and 10.95, respectively. Furthermore, SUV max for parotid glands and submandibular glands of all patients were 4.86 ± 1.89 and 4.64 ± 1.64, respectively (p = 0.694). Conclusions:This study investigated the 67 Ga SPECT-CT for the evaluation of head and neck, especially SUV max of lesions, and the parotid and submandibular glands. 67 Ga SPECT-CT may be an effective technique for the evaluation of maxillofacial lesions.

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Single-photon emission computed tomography/computed tomography for evaluation of salivary gland dysfunction: preliminary study on diagnostic ability of maximum standardized uptake value

Cited by 11 publications

References 11 publications

Can the function of the tubarial glands be evaluated using [99mTc]pertechnetate SPECT/CT, [18F]FDG PET/CT, and [11C]methionine PET/CT?

Can the function of the tubarial glands be evaluated using [99mTc]pertechnetate SPECT/CT, [18F]FDG PET/CT, and [11C]methionine PET/CT?

Volumetric analysis of mandibular lesions with SPECT/CT: a pilot clinical study of maximum standardized uptake value

Gallium-67 SPECT-CT for the evaluation of head and neck: preliminary study on maximum standardised uptake value in lesions, and in the parotid and submandibular glands

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