Single-Particle Study: Refractive Index Sensitivity of Localized Surface Plasmon Resonance Inflection Points in Mesoporous Silica-Coated Gold Nanorods

Heo, Seong Eun; Ha, Ji Won

doi:10.1007/s13206-022-00061-4

Cited by 14 publications

(6 citation statements)

References 19 publications

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“…wavelength of AuNRs can be finely tuned from the visible to the NIR region by altering the length-to-diameter aspect ratio. [8][9][10] Traditionally, synthesized AuNRs contain cetyltrimethylammonium bromide (CTAB) as a cationic surfactant to prevent aggregation or agglomeration. [11,12] However, CTAB is a potentially toxic chemical that may cause adverse effects, such as inhibition of adenosine triphosphate (ATP) synthase and destabilization of cell membranes.…”

Section: Introductionmentioning

confidence: 99%

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Structurally Engineered Silica Shells on Gold Nanorods for Biomedical Applications

et al. 2023

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Owing to their unique optical and chemical properties, gold nanorods (AuNRs) are among the most frequently used nanomaterials for biomedical applications, including cancer therapy, imaging, and drug delivery. In particular, the longitudinal dipole plasmon wavelength of AuNRs can be verified from the visible to the near‐infrared (NIR) region, allowing AuNRs to be used as photodynamic/photothermal and imaging contrast agents. At the same time, the silica shell is important as it enhances stability and facilitates the functionalization and biocompatibility of AuNRs, offering numerous advantages in biomedical applications. In this review, silica‐coated AuNRs from a bioapplication perspective are focused. First, the importance of AuNRs for biomedical applications is explained and the purpose of silica coating on AuNRs is discussed. Then, recent studies on the development of silica‐coated AuNRs from a biomedical perspective are reviewed. Subsequently, various strategies for engineering silica coatings and their properties in the biomedical field are reviewed. This review is expected to promote further research on next‐generation silica‐coated AuNRs for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

“…In particular, the longitudinal dipole plasmon wavelength of AuNRs can be finely tuned from the visible to the NIR region by altering the length‐to‐diameter aspect ratio. [ 8–10 ]…”

Section: Introductionmentioning

confidence: 99%

Structurally Engineered Silica Shells on Gold Nanorods for Biomedical Applications

et al. 2023

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“…We prepared the Cy5-mSiO 2 @GNRs that showed an improvement in sensing performance by maximal EF MEF , following the investigation of their optimum morphological conditions. We adopted GNRs as cores, as they have two surface plasmon resonances (transverse and longitudinal) that arise from the collective oscillation of conduction band electrons on the GNR surface, and exhibit a much stronger plasmonic resonance than gold nanoparticles. − Consequently, GNRs functionalized with fluorescent labels are widely employed in various biomedical applications, including imaging and therapy . Additionally, we used mSiO 2 as a shell to encapsulate a large amount of Cy5 fluorophores into the porous structures and provide an appropriate distance from the GNRs, as the level of fluorescence amplified by the MEF phenomenon significantly varies with the distance between the fluorophore and metal surface.…”

Section: Resultsmentioning

confidence: 99%

Plasmonic Approach to Fluorescence Enhancement of Mesoporous Silica-Coated Gold Nanorods for Highly Sensitive Influenza A Virus Detection Using Lateral Flow Immunosensor

Hong,

Jo,

Bang

et al. 2023

ACS Nano

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Rapid diagnostic tests based on the lateral flow immunoassay (LFI) enable early identification of viral infection, owing to simple interpretation, short turnaround time, and timely isolation of patients to minimize viral transmission among communities. However, the LFI system requires improvement in the detection sensitivity to match the accuracy of nucleic acid amplification tests. Fluorescence-based LFIs are more sensitive and specific than absorption-based LFIs, but their performance is significantly affected by fundamental issues related to the quantum yield and photobleaching of fluorophores. Metal-enhanced fluorescence (MEF), which is a plasmonic effect in the vicinity of metallic nanoparticles, can be an effective strategy to improve the detection sensitivity of fluorescence-based LFIs. The key factors for obtaining a strong plasmonic effect include the distance and spectral overlap of the metal and fluorophore in the MEF system. In this study, MEF probes were designed based on core−shell nanostructures employing a gold nanorod core, mesoporous silica shell, and cyanine 5 fluorophore. To optimize the efficiency of MEF probes incorporated on the LFI platform (MEF-LFI), we experimentally and theoretically investigated the distance dependence of plasmonic coupling between cyanine 5 and gold nanorods by adjusting the shell thickness, resulting in significant fluorescence enhancement. The proposed MEF-LFI enabled highly sensitive detection of influenza A virus (IAV) nucleocapsid protein with a detection limit of 0.52 pg mL −1 within 20 min and showed high specificity and accuracy for determining IAV clinical samples. Overall, our findings demonstrate the potential of this method as an effective tool for molecular diagnosis under emergency conditions.

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“…43,44 All nanomaterial categories have been extensively utilized for various biomedical applications, with intense research into the design of nanoparticles for medicinal and pharmaceutical applications revealing several advantages. [45][46][47] The use of nanomaterials for the treatment of neurological conditions has progressed considerably. Studies focusing on the use of nanomaterials against AD have yielded positive results.…”

Section: Nanotechnology For Ad Treatment and The Bbbmentioning

confidence: 99%

Nanotechnology-based delivery of therapeutics through the intranasal pathway and the blood–brain barrier for Alzheimer's disease treatment

Boyetey,

Choi,

Lee

et al. 2024

Biomater. Sci.

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Single-Particle Study: Refractive Index Sensitivity of Localized Surface Plasmon Resonance Inflection Points in Mesoporous Silica-Coated Gold Nanorods

Cited by 14 publications

References 19 publications

Structurally Engineered Silica Shells on Gold Nanorods for Biomedical Applications

Structurally Engineered Silica Shells on Gold Nanorods for Biomedical Applications

Plasmonic Approach to Fluorescence Enhancement of Mesoporous Silica-Coated Gold Nanorods for Highly Sensitive Influenza A Virus Detection Using Lateral Flow Immunosensor

Nanotechnology-based delivery of therapeutics through the intranasal pathway and the blood–brain barrier for Alzheimer's disease treatment

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