Single Oral Dose Toxicity Test and Four Weeks Repeated Oral Dose Determination Test of Crude Antifungal Compounds Produced by Bacillus subtilis SN7 in Rats

Gamisasangja-tang suppresses pruritus and atopic skin inflammation in the NC/Nga murine model of atopic dermatitis

“…These effects might lead to reduced thickening of the epidermis and dermis, and infiltration of eosinophils (CCR3 þ ) and mast cells (CD117 þ FcεRIα þ ) into skin as well as fewer erythematous skin lesions. Additionally, the previous dose (single and repeated) toxicity studies Han et al, 2013;Kim et al, 2014) revealed GST is safe. Current immunosuppressive therapeutics such as steroids and cyclosporine have considerable side effects such as nausea, abdominal discomfort, hypertension, hypothalamic-pituitary-adrenal axis dysregulation, and renal impairment (Madan and Griffiths, 2007).…”