Single Oral Dose Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats

Abstract

Objectives: Samjung-hwan (SJH) is a Korean herbal formula that has been used for antilipidemic, antioxidant, and antidepressant effects. As a part of safety evaluation, single oral dose toxicity study of modified SJH in Sprague-Dawley (SD) rats was carried out. Methods: Modified SJH extract was administered orally in male and female SD rats at dose of 5,000 mg/kg. After single oral administration of modified SJH, we monitored the changes of mortalities, clinical signs, and body weight daily for 14 days. Gross necropsy findings were also evaluated at the end of the experiment. Results: Modified SJH extract did not induce any toxic signs in the changes of mortalities, clinical signs, and body weight. There were also observed no gross necropsy findings in rats. Conclusions: As results, the approximate lethal dose of modified SJH extract in SD rats was considered to be over 5,000 mg/kg. This suggests that modified SJH is safe herbal formula for the treatment with.

Analysis of Research Trends in Papers Published in the Journal of Korean Medicine for Obesity Research: Focused on 2010-2019

“…(1) 동물연구(animal study) 54,55,57,58,61,62,65,66,69,72,73) , 당뇨유도모델을 활 용한 경우가 3편 60,64,68) 이었으며 이상지질혈증을 유도한 경 우는 2편 56,63) , 기타 질환을 유도한 경우는 5편 59,70,71,75,76) 이었 다. 비만관련 지표를 확인한 연구가 총 10편 54,55,57,58,61,62,65,66,69,73) 이었으며 지질대사와 관련한 연구가 6편 56,58,63,73,75,76) , 당대 사의 변화를 확인한 연구가 5편 [64][65][66]68,69) , 경구독성연구가 3편 55,67,74) , 호르몬 관련 연구가 2편 59,70) , 위장관 운동 관련 연구가 2편 60,68) 54,67,…”