Single oral dose of vitamin D3 supplementation prior to in vitro fertilization and embryo transfer in normal weight women: the SUNDRO randomized controlled trial

Somigliana, Edgardo; Sarais, Veronica; Reschini, Marco; Ferrari, Stefania; Makieva, Sofia; Cermisoni, Greta Chiara; Paffoni, A.; Papaleo, Enrico; Viganò, Paola

doi:10.1016/j.ajog.2021.04.234

Cited by 31 publications

(53 citation statements)

References 32 publications

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“…Among the remaining 12 potentially eligible records, we retrieved full-texts of 10 records because of 2 records were determined to be the conference abstract which reported insufficient information. Finally, 5 studies ( 27 – 31 ) were judged to meet our selection criteria after excluding 5 ineligible studies due to the following reasons, namely, ineligible regime (n = 1), ineligible study aim (n = 1), ineligible patients (n = 2), and unrelated to our topic (n = 1). We used Figure 1 to display the flow chart of study retrieval and selection.…”

Section: Resultsmentioning

confidence: 99%

“…Among enrolled 5 eligible studies, 3 studies ( 27 , 28 , 30 ) were performed in Iran and another 2 studies ( 29 , 31 ) were performed in Italy. The publication time of individual study ranged from 2014 to 2021.…”

Section: Resultsmentioning

confidence: 99%

“…Most eligible studies ( 27 – 30 ) enrolled inadequate sample size with a median number of 92, apart from 1 study performed by Somigliana et al. ( 31 ), in which 573 patients were included in the final analysis. Two studies ( 27 , 28 ) instructed patients to take orally vitamin D pearl capsule, 2 studies ( 29 , 31 ) instructed patients to take orally vitamin D3, and 1 study ( 30 ) instructed patients to take orally calcitriol pills.…”

Section: Resultsmentioning

confidence: 99%

“…Meanwhile, several systematic reviews ( 8 , 23 – 26 ) of observational studies further suggested that women with deficient or insufficient vitamin D have lower chances of IVF success, however whether vitamin D supplementation can improve IVF outcomes is still controversial. Agreeably, some randomized controlled trials (RCTs) ( 27 – 31 ) have also been performed to demonstrate the role of vitamin D in reproduction. Unfortunately, however, most of the published RCTs ( 27 – 30 ) were interventional studies with small sample size, which were underpowered to draw a definitive conclusion.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Vitamin D Supplementation on In Vitro Fertilization Outcomes: A Trial Sequential Meta-Analysis of 5 Randomized Controlled Trials

Zhou

Luo

et al. 2022

Front. Endocrinol.

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Despite numerous studies indicating an imperative role of vitamin D for reproduction, the importance of vitamin D supplementation on in vitro fertilization (IVF) outcomes remains controversial. We therefore performed this meta-analysis to investigate the IVF outcomes of vitamin D supplementation in infertile women with vitamin D deficiency. We systematically searched PubMed, Embase and the Cochrane library for identifying all relevant studies published before August 2021. Pregnancy rate was defined as the primary outcome while good quality embryo, fertilization rate, ongoing pregnancy, and miscarriage were secondary outcomes. We used Review Manager 5.3 (RevMan) to conduct meta-analysis and examined the robustness of the primary outcome by trial sequential analysis. Five studies were included in the final analysis and it suggested that vitamin D supplementation was associated with improved chemical pregnancy rate (risk ratio [RR] = 1.53, 95% confidence interval [CI] = 1.06 to 2.20, p = 0.02) but not benefited in improving clinical pregnancy rate (RR = 1.34, 95% CI = 0.81 to 2.24, p = 0.25) and all secondary outcomes. Trial sequential analysis suggested further studies are needed to confirm this conclusion. We concluded that vitamin D supplementation should be prescribed to improve chemical pregnancy in infertile women with vitamin D deficiency and more studies are required to further confirm this finding.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Vitamin D Supplementation on In Vitro Fertilization Outcomes: A Trial Sequential Meta-Analysis of 5 Randomized Controlled Trials

Zhou

Luo

et al. 2022

Front. Endocrinol.

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“…Men provided semen samples after 2 to 4 days of abstinence. IUI and IVF were standardized and performed as previously described (8)(9)(10). For IVF, oocyte collection was performed 36 h after triggering of ovulation.…”

Section: Methodsmentioning

confidence: 99%

COVID-19 Vaccination Does Not Affect Reproductive Health Parameters in Men

Reschini

Pagliardini

Boeri

et al. 2022

Front. Public Health

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With the implementation of COVID-19 vaccine up-take, doubts regarding the impact of immunization on future fertility have begun to emerge. We have examined vaccine safety on male reproductive health. We set up a multicentre (three infertility centers), retrospective study in order to assess semen parameters and fertilization rate of one hundred-six men in a pairwise comparison between the first and second assisted reproduction technology (ART) attempt, performed respectively before and after COVID-19 vaccination. Median time (range) between the first vaccine dose and the second ART cycle was 75 days (39–112). Semen parameters did not change before and after the exposure. Fertilization rate was also similar before and after vaccination. Twenty-five patients (24%) were oligozoospermic before the vaccination while 26 (25%) after the exposure (P = 0.87). Severe asthenozoospermia were present in 11 patients before as well as after the exposure. No difference was observed even after considering different types of vaccines (mRNA or viral vector). COVID-19 vaccination did not affect sperm quality and fertilization capacity of men undergoing ART treatments and should be considered safe for men's reproductive health.

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Supplementation with vitamin D improves the embryo quality in in vitro fertilization (IVF) programs, independently of the patients’ basal vitamin D status

Baldini,

Russo,

Proietti

et al. 2024

Arch Gynecol Obstet

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Purpose The study aims to demonstrate the effects of Vitamin D (VD) supplementation, prior to oocyte pick-up within IVF protocols, in women with diverse VD status at the enrollment. Methods A total of 204 women eligible for intra-cytoplasmatic sperm injection (ICSI) cycles were included in the study and two homogeneous groups were selected from the database. Both group of patients with normal VD baseline level (> 40 ng/ml) and patients with low VD baseline level (< 20 ng/ml) were divided into control group and treatment group. The control group followed the standard procedure. The treatment group was supplemented with vitamin D3 as cholecalciferol in combination with Myo-Inositol, folic acid, and melatonin 3 months before standard procedure, once a day in the evening. Results VD levels significantly increased in the study group of low baseline VD, both in serum and in the follicular fluid compared to controls. The treatment induced a significant improvement of the embryo quality in both group of patients considered. Conclusion Supplementation of VD in patients undergoing ICSI procedures significantly improved the number of top-quality embryos compared with the control group, either starting from VD normal baseline values or starting from low values. Trial registration number 07/2018.

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Single oral dose of vitamin D3 supplementation prior to in vitro fertilization and embryo transfer in normal weight women: the SUNDRO randomized controlled trial

Cited by 31 publications

References 32 publications

Effect of Vitamin D Supplementation on In Vitro Fertilization Outcomes: A Trial Sequential Meta-Analysis of 5 Randomized Controlled Trials

Effect of Vitamin D Supplementation on In Vitro Fertilization Outcomes: A Trial Sequential Meta-Analysis of 5 Randomized Controlled Trials

COVID-19 Vaccination Does Not Affect Reproductive Health Parameters in Men

Supplementation with vitamin D improves the embryo quality in in vitro fertilization (IVF) programs, independently of the patients’ basal vitamin D status

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