Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer’s disease
Andi Liu,
Citu Citu,
Nitesh Enduru
et al.
Abstract:Sporadic early-onset Alzheimer’s disease (sEOAD) represents a significant but less-studied subtype of Alzheimer’s disease (AD). Here, we generated a single-nucleus multiome atlas derived from the postmortem prefrontal cortex, entorhinal cortex, and hippocampus of nine individuals with or without sEOAD. Comprehensive analyses were conducted to delineate cell type-specific transcriptomic changes and linked candidatecis-regulatory elements (cCREs) across brain regions. We prioritized seven conservative transcript… Show more
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