Single Nucletide Polymorphisms in Gene of IL-1Beta in Bronchial Asthma

Abstract

Bronchial asthma is a common chronic lung disease that is driven by abnormal inflammatory reactions in the airways in response to the complex interaction between genetics and environmental factors. The underlying inflammation in asthma is We did not observe statistically significant differences in genotype frequencies of IL1B -511C>T and IL1B +3953C>T between controls and patients with asthma (p=0.065 and p=0.987). However, the minor T allele of IL1B -511C>T was less frequently found in the controls (0.305) compared to the patients with asthma (0.415, p=0.0002). Carriers of IL1B -511T allele (TT or TC genotypes) appeared to have 2.25-fold higher risk forBronchial asthma p=0.019). The performed estimations of IL1B haplotypes did not reveal any difference in the haplotype frequencies between controls and patients with asthma (p=0.270). However, the T_C haplotype, constructed by alleles found to determine enhanced expression of IL-1β, appeared to be associated with higher risk of asthma (OR 1.78, p=0.035)

IL-1? polymorphisms and its interaction with Nrg-1 on the risk of intellectual disability.

“…The IL-1β gene displays many SNPs both in promoter and coding regions, which have been associated with IL-1β production. The rs16944 and rs1143634 SNPs are respectively a promoter polymorphism and a silent polymorphism in exon 5 of IL-1β and are able to influence circulating protein expression [35]. There are several pieces of evidence of an association between the C allele of IL-1β rs1143634 and higher serum IL-1β concentrations [36].…”