Single nucleotide variations in the development of diabetic foot ulcer: A narrative review

Hu, Yanjun; Song, Chen-Sheng; Jiang, Nan

doi:10.4239/wjd.v13.i12.1140

Cited by 3 publications

(2 citation statements)

References 77 publications

(86 reference statements)

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“…Currently, diabetic foot ulcer (DFU) still poses a major challenge to physicians because its treatment is complex, associated with a high risk of infection, recurrence, limb amputation, and even death. Therefore, a comprehensive understanding of the pathogenesis of DFU is of great importance [2]. Hyperglycemia caused by T2DM leads to the formation of a pathogenetic triad in tissues: inflammation, endothelial dysfunction and hypercoagulation, disrupting the healing processes of diabetic wounds.…”

Section: Introductionmentioning

confidence: 99%

Role of Adaptation to Chronic Hypoxia in the Development of Dysimunic Disorders in Diabetic Foot Ulcer

Mikhaylichenko,

Bondarenko,

Yusupova

et al. 2024

ArveMED

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The purpose of the study is to establish the relationship between the immune-mediated DFU in patients with T2DM and the degree of HIF-2-dependent adaptation to chronic hypoxia. Materials and Methods: We conducted a comparative analysis of patients’ clinical characteristics, laboratory markers of infection and individual parameters of adaptive immunity in patients of the main group with neuropathic and neuroischemic forms of T2DM (subgroup 1, n=51, ulcer area less than 6 cm2; subgroup 2, n=28, ulcer area more than 6 cm2), as well as in patients of the comparison group (n=44) with similar forms of T2DM. It was found that the nature of the response to hypoxia, mediated by HIF-2α, played an important role in regulating the activity of the adaptive immune response and the inflammatory-reparative process in patients with T2DM and destructed foot tissue. Results: The presence of foot wounds in patients with T2DM indicates a disruption of the HIF-2α-dependent adaptive response, which is accompanied by activation of inflammatory mediators and a decrease in IgG-dependent mechanisms. In patients with T2DM, increased HIF-2α expression in combination with increased production of immunoglobulins, is obviously a protective mechanism that prevents defects of foot tissue. Conclusion: The clinical and laboratory use of hypoxia biomarkers is promising for predicting the risk of infectious and destructive complications in patients with T2DM.

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Section: Introductionmentioning

confidence: 99%

Role of Adaptation to Chronic Hypoxia in the Development of Dysimunic Disorders in Diabetic Foot Ulcer

Mikhaylichenko,

Bondarenko,

Yusupova

et al. 2024

ArveMED

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“…[ 1 ] Osteomyelitis and DFU both affect the inflammatory milieu, including inflammatory responses and immune responses, inflammatory chemokines and cytokines such as serum tumor necrosis factor (TNF)-α, interleukin (IL) 1β, and IL8. [ 2 ] Although DFU are considered a risk factor for osteomyelitis, the common pathogenesis of these 2 diseases remains poorly studied. Neutrophils may play a vital role in this, and osteomyelitis and DFU may have a common pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Exploring the pathogenesis of osteomyelitis accompanied by diabetic foot ulcers using microarray data analysis

Fan,

Ye,

Zhu

et al. 2023

Medicine

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Although numerous studies have shown distinctive similarities between osteomyelitis and diabetic foot ulcers (DFU), the common pathogenesis of both is not fully understood. The current research focuses on an in-depth study of the molecular and pathway mechanisms involved in the complication of these 2 diseases. We downloaded clinical information on osteomyelitis (GSE30119) and DFU (GSE29221) from the GEO database, along with gene expression matrices. Differentially expressed genes (DEGs) among normal individuals and patients with osteomyelitis; normal individuals and patients with DFU were identified by R software, and thus common DEGs were confirmed. We then analyzed these differential genes, including the functional pathway analysis, protein–protein interaction (PPI), modules and hub genes establishment, and transcription factor regulatory networks. We identified 109 common DEGs (46 up-regulated and 63 down-regulated genes) for subsequent analysis. The results of PPI network and the functional pathway analysis revealed the importance of immune response and inflammatory response in both diseases. Among them, chemokines and cytokines were found to be closely related to both osteomyelitis and DFU. In addition, the tumor necrosis factor (TNF) pathway and Staphylococcus aureus infection were found to have more significant roles too. The 12 most essential key genes were later screened by cytoHubba, including matrix metalloproteinases (MMP) 1, MMP3, MMP9, IL8, C-X-C chemokine receptor (CXCR) 2, C-X-C motif chemokine ligand (CXCL) 9, CXCL10, CXCL13, FCGR3B, IL1B, LCN2, S100A12. CXCL10, and MMP1 were validated using the least absolute shrinkage and selection operator (LASSO) and support vector machine-recursive feature elimination (SVM-RFE) algorithms. Osteomyelitis and DFU share similar molecular and pathway mechanisms. These common key genes and pathways may provide new directions toward the future study of osteomyelitis and DFU.

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Exploring an Innovative Approach: Integrating Negative-Pressure Wound Therapy with Silver Nanoparticle Dressings in Skin Graft Procedures

Abu-Baker,

Țigăran,

Peligrad

et al. 2024

JPM

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Background: Skin grafting is a helpful instrument in a plastic surgeon’s arsenal. Several types of dressings were designed to facilitate the process of graft integration. Negative-pressure wound therapy is a proven dressing method, enhancing graft survival through several mechanisms: aspiration of secretions, stimulation of neoangiogenesis, and promotion of an anti-inflammatory environment. Silver nanoparticle dressings also bring multiple benefits by bearing an antimicrobial effect and providing a humid medium, which are favorable for epithelialization. The combination of NPWT (negative-pressure wound therapy) with AgNPs (silver nanoparticles) has not been widely studied. Materials and methods: This study aimed to compare the outcomes of silver nanoparticle sheets with the combination of negative-pressure wound therapy and silver nanoparticle dressings. We conducted a comparative prospective study on 80 patients admitted to the Plastic Surgery Department of “Prof. Dr. Agrippa Ionescu” Emergency Clinical Hospital between 1st of January 2020 and 31st of December 2022. The study population was randomized to receive either silver nanoparticle dressings or negative-pressure wound therapy (NPWT) combined with silver nanoparticle dressings. Various parameters were monitored, including patient comorbidities and graft-related data such as defect etiology, graft integration, and graft size. Dressings were changed, and graft status was evaluated at 7, 10, and 14 days postoperatively. Additionally, baseline C-reactive protein (CRP) levels were measured before surgery and 7, 10, and 14 days postoperatively. Results: The study demonstrated an enhanced integration of skin grafts at all evaluation stages when employing NPWT combined with AgNPs, particularly evident 10 days post operation. Significant variations in graft integration were also observed based on factors such as diabetes, cardiovascular disease, graft size, or the origin of the grafted defect. Moreover, dynamic C-reactive protein monitoring showed a statistically significant decrease in CRP levels 10 days post operation among patients treated with NPWT in conjunction with silver dressing, consistent with the nearly complete integration of skin grafts at this evaluation threshold. Conclusion: Several factors influence the postoperative evolution of split-skin grafts. Postoperative dressings target local factors to enhance graft integration further. Our research demonstrated that the innovative combination of NPWT-assisted dressings, complemented by a silver nanoparticle sheet, resulted in improved benefits for graft integration and the alleviation of systemic inflammation.

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Single nucleotide variations in the development of diabetic foot ulcer: A narrative review

Cited by 3 publications

References 77 publications

Role of Adaptation to Chronic Hypoxia in the Development of Dysimunic Disorders in Diabetic Foot Ulcer

Role of Adaptation to Chronic Hypoxia in the Development of Dysimunic Disorders in Diabetic Foot Ulcer

Exploring the pathogenesis of osteomyelitis accompanied by diabetic foot ulcers using microarray data analysis

Exploring an Innovative Approach: Integrating Negative-Pressure Wound Therapy with Silver Nanoparticle Dressings in Skin Graft Procedures

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