Single nucleotide polymorphisms (SNPs) of pro-inflammatory/anti-inflammatory and thrombotic/fibrinolytic genes in patients with acute ischemic stroke in relation to TOAST subtype

Tuttolomondo, Antonino; Raimondo, Domenico Di; Forte, Giusi Irma; Casuccio, Alessandra; Vaccarino, Loredana; Scola, Letizia; Pecoraro, Rosaria; Serio, Antonia; Clemente, Giuseppe; Arnao, Valentina; Palmeri, Marisa; Misiano, Gabriella; Lio, Domenico; Pinto, Antonio; Licata, Giuseppe

doi:10.1016/j.cyto.2012.02.012

Cited by 68 publications

(56 citation statements)

References 42 publications

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“…Many environmental factors, including age, obesity, hypertension, inflammation, smoking, diabetes mellitus (DM) and lipid disorders, have been established as risk factors for IS. In addition, previous studies also suggest that genetic background can determine the predisposition to IS [4,5,6,7,8,9,10]. …”

Section: Introductionmentioning

confidence: 99%

OPN Gene Polymorphism and the Serum OPN Levels Confer the Susceptibility and Prognosis of Ischemic Stroke in Chinese Patients

Meng¹,

Hou

et al. 2013

Cell Physiol Biochem

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Aim: To investigate the association of Osteopontin (OPN) gene polymorphism and serum thrombin-cleaved OPN level with the susceptibility to ischemic stroke (IS) and its prognosis. Methods: A total of 377 patients with IS and 551 healthy individuals were recruited. The OPN gene polymorphisms at -156 G>GG, -443 C>T and -66 T>G were genotyped. Serum full-length and the thrombin-cleaved OPN were determined. Results: We found that only the -443 C>T polymorphism was significantly associated with the susceptibility to IS. The -443 CC represented a near 2 time higher risk for IS incidence than TT carriers. Also, the -443 CC genotype had significantly poorer outcome and they significantly had higher occurrence for bad recovery as determined by modified Rankin Scale (mRS) (OR=2.18, p=0.043) and Barthel Index (BI) (OR=2.12, p=0.05). The mean serum thrombin-cleaved OPN level in IS group were significantly higher than that in control group. ROC analysis showed that the thrombin-cleaved OPN level (cut-off value, 166.8 ng/ml) can discriminate IS patients from controls with a specificity of 86.3% and a sensitivity of 57.7%. The serum thrombin-cleaved OPN was significantly associated with the clinical outcome at 12 months after discharge from hospital. Conclusion: These results suggest that the -443 C>T polymorphism of OPN gene and serum thrombin-cleaved OPN can be used as a biomarker for the susceptibility and prognosis of IS patients.

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Section: Introductionmentioning

confidence: 99%

OPN Gene Polymorphism and the Serum OPN Levels Confer the Susceptibility and Prognosis of Ischemic Stroke in Chinese Patients

Meng¹,

Hou

et al. 2013

Cell Physiol Biochem

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“…Previous studies demonstrated that inflammation and excitotoxicity have great importance in the pathology of stroke [2,4,9]. Stroke induces strong inflammatory responses [10,11,12,13,14,15]. These responses are also caused by the activation and release of inflammatory chemokines [16], cytokines [16], proteolytic enzymes [17], and adhesion molecules resulting in tissue damage.…”

Section: Introductionmentioning

confidence: 99%

The Possible Role of Toll-Like Receptor 4 in the Pathology of Stroke

Hakimizadeh

Arababadi

Shamsizadeh

et al. 2016

Neuroimmunomodulation

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Stroke is a prevalent and dangerous health problem, which triggers an intense inflammatory response to Toll-like receptor (TLR) activation. TLRs are the essential components of the response of the innate immunity system, and, therefore, they are one of the key factors involved in recognizing pathogens and internal ligands. Among TLRs, TLR4 significantly participates in the induction of inflammation and brain functions; hence, it has been hypothesized that this molecule is associated with several immune-related brain diseases such as stroke. It has also been proved that animals with TLR4 deficiency have higher protection against ischemia and that the absence of TLR4 reduces neuroinflammation and injuries associated with brain trauma. TLR4 deficiency may play a neuroprotective role in the occurrence of stroke. This article reviews recent information regarding the impact of TLR4 on the pathogenicity of stroke.

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“…Figure 1 shows the results of literature search and selection. A total of 186 articles were retrieved with the comprehensive literature search, and finally 25 articles (Bai and Cheng 2004;Balding et al 2004;Lee et al 2004;Um and Kim 2004;Karahan et al 2005;Rubattu et al 2005;Harcos et al 2006;Lalouschek et al 2006;Llamas Sillero et al 2007;Zhang et al 2007;Liu et al 2009Liu et al , 2012Shi et al 2009;Kim et al 2010;Tong et al 2010;Markoula et al 2011;Munshi et al 2011;Sultana et al 2011;Szabo and Acsady 2011;Wu et al 2011;Cui et al 2012;Tuttolomondo et al 2012;Gelfand et al 2013;Ma 2012) (18 in English and seven in Chinese) of them were included in the present study according to the eligible criteria. Forty-nine eligible case-control studies from these 25 articles involve 23 studies of -308G/A (6220 patients and 6531 controls), 14 studies of -238G/A (4760 patients and 4389 controls), four studies of -857C/T (2589 patients and 2097 controls), three studies of -1031T/C (2416 patients and 1948 controls), one study (404 patients and 415 controls) of -244G/ A and -367G/A, one study (67 patients and 70 controls) of -646G/A, -806C/T, -863C/A, and one study (525 patients and 500 controls) of ?448G/A.…”

Section: Discussionmentioning

confidence: 99%

“…Tong et al 2010;Sultana et al 2011;Szabo and Acsady 2011;Cui et al 2012;Tuttolomondo et al 2012;Gelfand et al 2013;Ma 2012) reported G allele frequencies, with 13 studies of Asian adults, one of Asian children, seven of Caucasian adults, and two of Caucasian children.…”

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confidence: 97%

Systematic Review by Multivariate Meta-analyses on the Possible Role of Tumor Necrosis Factor-α Gene Polymorphisms in Association with Ischemic Stroke

et al. 2015

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A number of studies have investigated the association between tumor necrosis factor (TNF)-α gene polymorphisms and ischemic stroke susceptibility. However, results of different individual studies are often inconsistent. To provide a more robust evaluation of the association between polymorphisms of the TNF-α gene and ischemic stroke risk, we performed a systematic review with multivariate meta-analyses. PubMed, Embase, CNKI, and WanFang databases were searched up to December 20, 2014. Two reviewers independently extracted information and assessed quality of included studies after all the eligible studies were identified. Afterward, multivariate meta-analyses were performed using Stata 13. The estimation of polymorphisms and disease risk was presented by odds ratios (ORs) and corresponding 95 % confidence intervals (CIs). Forty-nine eligible case-control studies from 25 articles that explored the association between 10 TNF-α polymorphisms and ischemic stroke were indentified from aforementioned databases. The results of multivariate meta-analysis showed a significant association between -238G/A polymorphism (4760 patients and 4389 controls) and ischemic stroke risk in heterozygotes compared with wild genotype (AG vs. GG: OR 1.44, 95 % CI 1.11-1.87; AA vs. GG: OR 1.98, 95 % CI 0.73-5.40). No significant association of -308G/A, -857C/T, and -1031T/C polymorphisms was observed. The results of stratification analyses of -238G/A polymorphism showed that the AG genotype only increased the risk of ischemic stroke in Asians compared to GG genotype. No additional significant association was observed in this study. In conclusion, the present systematic review and meta-analysis support a prominent role of the TNF-α -238G/A polymorphism in the risk of ischemic stroke in Asian adults only, but do not support the role of -308G/A, -857C/T, -1031T/C, -244G/A, -367G/A, -646G/A, -806C/T, -863C/A, and +448G/A in the risk of ischemic stroke. The current evidence warrants further studies with high quality and large sample size to confirm.

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Single nucleotide polymorphisms (SNPs) of pro-inflammatory/anti-inflammatory and thrombotic/fibrinolytic genes in patients with acute ischemic stroke in relation to TOAST subtype

Cited by 68 publications

References 42 publications

OPN Gene Polymorphism and the Serum OPN Levels Confer the Susceptibility and Prognosis of Ischemic Stroke in Chinese Patients

OPN Gene Polymorphism and the Serum OPN Levels Confer the Susceptibility and Prognosis of Ischemic Stroke in Chinese Patients

The Possible Role of Toll-Like Receptor 4 in the Pathology of Stroke

Systematic Review by Multivariate Meta-analyses on the Possible Role of Tumor Necrosis Factor-α Gene Polymorphisms in Association with Ischemic Stroke

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