Single Nucleotide Polymorphisms of the Mannose-binding Lectin are Associated with Susceptibility to Primary Biliary Cirrhosis

Matsushita, Masanao; Miyakawa, Hiroshi; Tanaka, Atsushi; Hijikata, Makoto; Kikuchi, Kentaro; Fujikawa, Hirotoshi; Arai, Junya; Sainokami, Shigehiko; Hino, Kunihiko; Terai, Itaru; Mishiro, Shunji; Gershwin, M. Eric

doi:10.1006/jaut.2001.0538

Cited by 41 publications

(20 citation statements)

References 43 publications

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“…The functional effect of the epsilon4 Apo E allele on macrophage phagocytosis of apoptotic cells is unknown, but Apo E À/À mice have decreased macrophage phagocytosis of apoptotic cells and a systemic pro-inflammatory state [35]. Other genetic polymorphisms associated PBC involving tolllike receptor 9 and mannose binding lectin may also directly or indirectly affect macrophage phagocytosis of apoptotic cells [36,37].…”

Section: Discussionmentioning

confidence: 95%

Anti-CD16 autoantibodies and delayed phagocytosis of apoptotic cells in primary biliary cirrhosis

Allina

Stanca

Garber

et al. 2008

Journal of Autoimmunity

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Primary biliary cirrhosis is characterized by chronic hepatic inflammation and immune mediated apoptosis of bile duct epithelial cells. Delayed macrophage phagocytosis of opsonized apoptotic cells, noted in other autoimmune diseases, may promote inflammation. Recent studies suggest serum anti-CD16 autoantibodies contribute to impaired macrophage phagocytosis by blocking complement receptor 3 (CR3) signaling via CD16. Therefore, serum anti-CD16 levels and the ability of monocyte derived macrophages from individuals with PBC to phagocytosis apoptotic cells were compared to controls. The mean level of anti-CD16 IgM autoantibodies (0.86+/-0.62 v. 0.35+/-0.22, respectively, p=0.031) was increased in PBC compared to control sera, and mean PBC phagocytosis of opsonized apoptotic cells was significantly decreased compared to controls (23.9+/-12.2% v. 43.9+/-14.4%, respectively, p=0.020). However, PBC phagocytosis of opsonized apoptotic cells was not significantly affected by the presence or absence of autologous serum (20.8+/-13.5% v. 23.9+/-12.2%, respectively, p=0.560). PBC phagocytosis of opsonized apoptotic cells inversely correlated with CD16 (and CR3) expression levels on Day 5 after culture in the presence or absence of autologous serum (r=-0.546, p=0.033 and r=-0.519, p=0.042, respectively). Phagocytosis of non-opsonized apoptotic cells did not correlate with CD16 or CR3 expression (p>0.050). In conclusion, PBC macrophage phagocytosis of opsonized apoptotic cells is impaired, irrespective of serum factors and may increase hepatic inflammation.

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Section: Discussionmentioning

confidence: 95%

Anti-CD16 autoantibodies and delayed phagocytosis of apoptotic cells in primary biliary cirrhosis

Allina

Stanca

Garber

et al. 2008

Journal of Autoimmunity

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“…Matsushita et al [28] reported that individuals carrying hyperproducing MBL genotype had an increased risk for PBC. Serum MBL concentrations were also significantly elevated in patients compared to healthy controls.…”

Section: Discussionmentioning

confidence: 98%

Mannose-binding lectin deficiency confers risk for bacterial infections in a large Hungarian cohort of patients with liver cirrhosis

Altorjay

Vitális

Tornai

et al. 2010

Journal of Hepatology

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“…There have been many reports of other immunorelated gene polymorphisms in patients with PBC such as polymorphisms in mannose-binding lectin 19 ), cytokeratin-19 pseudogene 20 ), interleukin-10 promotor gene 2 1), endothelial nitric oxide synthesis gene 22 ), and toll-like receptor-9 gene 23 ). All of those studies showed an association with susceptibility of PBC, but analysis of single gene polymorphism induces limit.…”

Section: Discussionmentioning

confidence: 99%

Possible Association of Cytotoxic T Lymphocyte Antigen-4 Genetic Polymorphism With Liver Damage of Primary Biliary Cirrhosis in Japan

Kanno

Rai

Monoe

et al. 2006

FJMS

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Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an important inhibitor of T -lymphocyte response. Polymorphisms in the CTLA-4 gene have been reported to be associated with numerous autoimmune diseases. The aim of this study was to determine whether polymorphisms of CTLA-4 exon 1 (+49) genes are associated with susceptibility and clinicolaboratory findings of primary biliary cirrhosis (PBC) in the J apanease population. Blood samples were obtained from 45 patients (6 men and 39 women, aged 23-56 years) with PBC and 73 healthy controls (48 men and 25 women, aged 22-72 years). CTLA-4 ex on 1 (+49) polymorphism was defined using a polymerase chain reaction-restriction fragment length polymorphism with Bst71I restriction enzyme. The genotype frequencies of AI A, A/G, and GIG in 45 patients with PBC were 11% (5 patients), 44% (20 patients), and 44% (20 patients), respectively. There was no significant difference between frequencies in PBC patients and healthy controls. PBC patients with GIG genotype had significantly higher serum levels of ALT, GGT, and IgM than those in patients with AI A or A/G genotype. In conclusion, CTLA -4 gene polymorphisms are not associated with susceptibility of PBC in Japan; however, GIG genotype may be associated with liver damage.

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Single Nucleotide Polymorphisms of the Mannose-binding Lectin are Associated with Susceptibility to Primary Biliary Cirrhosis

Cited by 41 publications

References 43 publications

Anti-CD16 autoantibodies and delayed phagocytosis of apoptotic cells in primary biliary cirrhosis

Anti-CD16 autoantibodies and delayed phagocytosis of apoptotic cells in primary biliary cirrhosis

Mannose-binding lectin deficiency confers risk for bacterial infections in a large Hungarian cohort of patients with liver cirrhosis

Possible Association of Cytotoxic T Lymphocyte Antigen-4 Genetic Polymorphism With Liver Damage of Primary Biliary Cirrhosis in Japan

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