Single nucleotide polymorphisms of myostatin gene in Chinese domestic horses

Li, Ran; Liu, Donghua; Cao, Chunna; Wang, Shaoqiang; Dang, Ruihua; Lan, Xianyong; Chen, Hong; Zhang, Tao; Liu, Wujun; Lei, Chuzhao

doi:10.1016/j.gene.2013.12.027

Cited by 11 publications

(11 citation statements)

References 25 publications

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“…Subsequently, 15 Chinese breeds were studied to select the best Chinese domestic breed for evaluating potential racing performances (Li et al . ). These studies found six different SNPs in MSTN : two SNPs (g.26T>C and g.156T>C) in the promoter region, two (g.587A>G and g.598C>T) in the 5′‐UTR region and two (g.1485C>T and g.2115A> G) in intron 1 of the equine MSTN .…”

Section: Myostatin Polymorphisms In Horsementioning

confidence: 97%

“…The g.66495254C>T polymorphism (also referred to as g.598C>T; Li et al . ) has been described in Chinese horse breeds as well as in Polish Konik and Arabian horse breeds. The g.66493737C>T polymorphism, known to predict optimum distance in Thoroughbred horses, has been identified in four breeds in Egyptian bloodlines (Bower et al .…”

Section: Myostatin Polymorphisms In Horsementioning

confidence: 99%

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Themyostatingene: an overview of mechanisms of action and its relevance to livestock animals

2018

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Myostatin, also known as growth differentiation factor 8, a member of the transforming growth factor-beta super-family, is a negative regulator of muscle development. Myostatin acts at key points during pre- and post-natal life of amniotes that ultimately determine the overall muscle mass of an animal. Mutations have already demonstrated the impact of attenuating myostatin activity on muscle development. A number of large animals, including cattle, sheep, dogs and humans, display the 'double muscled' phenotype due to mutations in the myostatin gene. Here, we firstly give an overview of the molecular pathways regulated by myostatin that control muscle development. Then we describe the natural mutations and their associated phenotypes as well as the physiological influence of altering myostatin expression in livestock animals (cattle, sheep, goat, horse, pig, rabbit and chicken). Knowledge of null alleles and polymorphisms in the myostatin gene are of great interest in the animal breeding field, and it could be utilized to improve meat production in livestock animals.

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Section: Myostatin Polymorphisms In Horsementioning

confidence: 97%

Section: Myostatin Polymorphisms In Horsementioning

confidence: 99%

Themyostatingene: an overview of mechanisms of action and its relevance to livestock animals

2018

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“…A larger population of 1396 horses was used in another study to validate the gene in a genomewide association study (GWAS) and an estimated breeding value (EBV) analysis [22] . Notably, the MSTN locus was also found in Chinese horse breeds [23] . All these studies indicate that the MSTN locus has a pivotal role in race horse performance.…”

Section: Racing Performancementioning

confidence: 92%

“…In Chinese horse breeds, six SNPs (g.26T > C, g.156 T > C, g.587A > G, g.598C > T, g.1485C > T, g.2115 A > G) in the MSTN gene were detected by sequencing [23] . Unfortunately, no racing performance association studies have been conducted in these horses and it would, therefore, be meaningful to know whether the MSTN locus is associated with racing performance in Chinese horse breeds.…”

Section: Racing Performancementioning

confidence: 99%

Genomic regions under selection for important traits in domestic horse breeds

Liu¹,

Ma²,

Jiang³

2017

Front. Agr. Sci. Eng.

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Horses were domesticated 5500 years ago, thousands of years later than other domestic animals; however, in this relatively short period, domestic horses have had a great impact on human history by accelerating civilization, revolutionizing warfare and advancing agricultural production. Modern breeding using markerassisted selection has greatly accelerated breeding progress. Therefore, identification of genetic markers underlying the traits of interest in domestic horses is the basis for the modern breeding system. In this review, we present an overview of genetic mapping studies and genome wide analyses to identify the genomic regions targeted by positive selection for four important aspects of horses, coat color, racing performance, gait and height at withers. The MC1R locus, for example, has been shown to be the main gene responsible for chestnut color, and the MSTN locus has been shown to control the muscle fiber growth in racing breeds. The missense mutation in DMRT3 is the causal mutation for the alternate gaits in horses. Height at withers, a quantitative trait, was mapped to four major loci (3:105547002, 6:81481064, 9:75550059 and 11:232597 32) that can explain 83% of the height variations in domestic horses.

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“…However, to date only a few studies have analyzed horse MSTN gene polymorphisms in different horse breeds and types (Dall'Olio et al, 2010;Baron et al, 2012;Li et al, 2014;Stefaniuk et al, 2014a). In this study, we analyzed a region of the MSTN gene (rev.str.66,495,489,608;chr.…”

Section: Introductionmentioning

confidence: 99%