Single Nucleotide Polymorphisms of Interleukin-1 beta Related Genes and their Associations with Infection in the Horse

Hořín, Petr; Osičková, Jitka; Nečesánková, Michaela; Matiašovic, Ján; Musilová, Petra; Kubı́čková, Svatava; Hubertova, D; Vyskočil, M.; Rubeš, Jiřı́

doi:10.1159/000317184

Cited by 5 publications

(3 citation statements)

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“…With the advent of genome-wide panels of single nucleotide polymorphisms (SNPs), SNPs have been widely used for the detection and localization of QTL for complex traits in many species [7], and have proved powerful and useful in identification of casual mutations associated with economically important traits in livestock [8], [9], [10], [11], [12], [13], [14], [15] as well as human diseases [16], [17], [18], [19]. Most recently, along with maturing of genome sequencing and high throughput SNP genotyping technologies, genome-wide association studies (GWAS) are becoming practical for exploring genes associated with complex traits.…”

Section: Introductionmentioning

confidence: 99%

Genome Wide Association Studies for Milk Production Traits in Chinese Holstein Population

et al. 2010

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Genome-wide association studies (GWAS) based on high throughput SNP genotyping technologies open a broad avenue for exploring genes associated with milk production traits in dairy cattle. Motivated by pinpointing novel quantitative trait nucleotide (QTN) across Bos Taurus genome, the present study is to perform GWAS to identify genes affecting milk production traits using current state-of-the-art SNP genotyping technology, i.e., the Illumina BovineSNP50 BeadChip. In the analyses, the five most commonly evaluated milk production traits are involved, including milk yield (MY), milk fat yield (FY), milk protein yield (PY), milk fat percentage (FP) and milk protein percentage (PP). Estimated breeding values (EBVs) of 2,093 daughters from 14 paternal half-sib families are considered as phenotypes within the framework of a daughter design. Association tests between each trait and the 54K SNPs are achieved via two different analysis approaches, a paternal transmission disequilibrium test (TDT)-based approach (L1-TDT) and a mixed model based regression analysis (MMRA). In total, 105 SNPs were detected to be significantly associated genome-wise with one or multiple milk production traits. Of the 105 SNPs, 38 were commonly detected by both methods, while four and 63 were solely detected by L1-TDT and MMRA, respectively. The majority (86 out of 105) of the significant SNPs is located within the reported QTL regions and some are within or close to the reported candidate genes. In particular, two SNPs, ARS-BFGL-NGS-4939 and BFGL-NGS-118998, are located close to the DGAT1 gene (160bp apart) and within the GHR gene, respectively. Our findings herein not only provide confirmatory evidences for previously findings, but also explore a suite of novel SNPs associated with milk production traits, and thus form a solid basis for eventually unraveling the causal mutations for milk production traits in dairy cattle.

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Section: Introductionmentioning

confidence: 99%

Genome Wide Association Studies for Milk Production Traits in Chinese Holstein Population

et al. 2010

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“…, 2004). In a subsequent study, positional candidate genes IL1B and IL1RN (interleukin‐1 receptor antagonist) genes were not associated with infection in this group, but a single nucleotide polymorphism (SNP) within a functionally related gene, Casp1 encoding the IL‐1 beta converting enzyme caspase 1 was associated with high burden of bacteria in the transtracheal aspirates (Horin et al. , 2008).…”

Section: Introductionmentioning

confidence: 90%

Immunity‐related gene single nucleotide polymorphisms associated with Rhodococcus equi infection in foals

Hořín

Sabakova

Futas

et al. 2010

Int J Immunogenetics

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In previous work, we found significant associations of horse polymorphic microsatellite and immunity-related (IR) gene markers with Rhodococcus equi infection of foals. Here, a statistically significant association between a single nucleotide polymorphism (SNP) within the interleukin 7 receptor-encoding gene (IL7R) with high R. equi burden in transtracheal aspirates was found (Fisher's F = 0.043, odds ratio: 8.00, 95% confidence interval: 1.127-56.795). Further positional and/or functional candidate genes investigated TLR2, IL13, IL17A, IL28R, TACE/ADAM 17 and GBP1, were not associated with infection in this study. SNPs analysed were found by sequencing and appropriate restriction fragment length polymorphism markers were developed. Their associations with R. equi infection were tested by genotyping thoroughbred foals from the original study. The association was confirmed by analysing genotypes composed with genes previously reported to be associated with R. equi infection in the same group.

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“…Susceptibility to R. equi pneumonia has also been shown to be linked to the solute carrier family 11 member 1 ( SLC11A1 ; NRAMP1 ) gene , a divalent transition iron and manganese transporter involved in iron metabolism and known to influence host susceptibility to certain infections such as tuberculosis in man for instance . Susceptibility to pneumonia caused by R. equi in foals was also linked to an intronic SNP of the Casp1 gene, which is functionally related to interleukin (IL)‐1β . This inflammatory cytokine is produced by macrophages, and polymorphisms in this gene have been associated with susceptibility to influenza and tuberculosis in man .…”

Section: Several Genes Influence Resistance/susceptibility To Infectimentioning

confidence: 99%

Genetics of upper and lower airway diseases in the horse

Gerber

Tessier

Marti

2014

Equine Veterinary Journal

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Genetic predispositions for guttural pouch tympany, recurrent laryngeal neuropathy and recurrent airway obstruction (RAO) are well documented. There is also evidence that exercise-induced pulmonary haemorrhage and infectious diseases of the respiratory tract in horses have a genetic component. The clinical expression of equine respiratory diseases with a genetic basis results from complex interactions between the environment and the genetic make-up of each individual horse. The genetic effects are likely to be due to variations in several genes, i.e. they are polygenic. It is therefore unlikely that single gene tests will be diagnostically useful in these disorders. Genetic profiling panels, combining several genetic factors with an assessment of environmental risk factors, may have greater value, but much work is still needed to uncover diagnostically useful genetic markers or even causative variants for equine respiratory diseases. Nonetheless, chromosomal regions associated with guttural pouch tympany, recurrent laryngeal neuropathy and RAO have been identified. The association of RAO with other hypersensitivities and with resistance to intestinal parasites requires further study. This review aims to provide an overview of the available data and current thoughts on the genetics of equine airway diseases.

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Single Nucleotide Polymorphisms of Interleukin-1 beta Related Genes and their Associations with Infection in the Horse

Cited by 5 publications

References 0 publications

Genome Wide Association Studies for Milk Production Traits in Chinese Holstein Population

Genome Wide Association Studies for Milk Production Traits in Chinese Holstein Population

Immunity‐related gene single nucleotide polymorphisms associated with Rhodococcus equi infection in foals

Genetics of upper and lower airway diseases in the horse

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