Single nucleotide polymorphisms of enamel formation genes and early childhood caries - systematic review, gene-based, gene cluster and meta-analysis

Polymorphisms in ENAM, AMBN, and KLK4 predispose Egyptian adults to dental caries: A cross-sectional study

“…These investigations have deepened our understanding of the genetic components influencing caries (A. Sharma et al, 2023 , Sharma and Bhandary, 2023 ). Caries experience was determined primarily using DMF-T scores, with adjustments for subject age to address DMF-T score limitations.…”

“…The SNP rs198968 A/G was linked to early childhood caries, observing protective effects against it with the genotypes AG and GG. KLK4 polymorphism in vulnerable populations disrupts the balance between proteolytic enzymes and MMP regulation, particularly MMP13 and MMP20 , in terms of deteriorating enamel mineralization ( Molaei & Motahari, 2022 ; D. Sharma and Bhandary, 2023 , Sharma et al, 2023 ). In contrast, the C/G SNP rs198969, especially the wild-type allele G and genotype GG and the G/A rs2235091 haplotype, were prevalent in children with dental caries (D. Sharma and Bhandary, 2023 , Sharma et al, 2023 ).…”