Single Nucleotide Polymorphisms of Cytokine Genes are Associated with Fibrosis of the Intrahepatic Bile Duct Wall in Human Clonorchiasis

Chung, Byung Suk; Lee, Jeong Keun; Choi, Min Ho; Park, Myoung Hee; Choi, Dongil; Hong, Sung Tae

doi:10.3347/kjp.2009.47.2.145

Cited by 3 publications

(4 citation statements)

References 14 publications

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Section: Discussionsupporting

confidence: 90%

“…The described genotype and allele frequencies of the IL-10 polymorphisms studied in this cohort are quite similar to previously reported distributions in other studies in Chinese patients [18-20,25] and other Asian populations [30]. The minor alleles at positions -819 and -592 are the C allele in Asian populations [18-20,25,30], which is different to those seen in Western populations, being T and A alleles, respectively [22-24,26,31]. Although the minor allele at position -1082 is G in both Asian and Western populations, its frequency is quite different, over 40% in Western populations [21,22,26,31,32] and about 10% in Asian populations [19-21].…”

Section: Discussionsupporting

confidence: 90%

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Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma: genetic association studies

Chen

Jiang

et al. 2009

Crit Care

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IntroductionAn excessive inflammatory response is thought to account for the pathogenesis of sepsis and multiple organ dysfunction syndrome (MODS) after severe trauma. The interleukin-10 (IL-10) is a potent anti-inflammatory cytokine. The objectives of this prospective study were to investigate the distribution of IL-10 promoter polymorphisms in a cohort of 308 Chinese Han patients with major trauma, and to identify associations of IL-10 promoter polymorphisms with IL-10 production and incidence of sepsis and MODS.MethodsA total of 308 patients with major trauma were included in this study. The genotypes of polymorphisms -1082, -819 and -592 were determined by polymerase chain reaction-restriction fragment length polymorphism. The IL-10 levels in the supernatants were determined with enzyme-linked immunoabsorbent assay.ResultsThe -1082A and -592A alleles were significantly associated with lower lipopolysaccharide-induced IL-10 production in an allele-dose dependent fashion. There was no significant difference for the -819 polymorphism. Except for the -1082 polymorphism, the -819 and -592 polymorphisms were not significantly associated with sepsis morbidity rate and MOD scores.ConclusionsOur results further confirm the functionality of the IL-10 promoter single nucleotide polymorphisms in relation to IL-10 production. They also suggest that individual difference in IL-10 production in trauma patients might be at least in part related to genetic variations in the IL-10 promoter region.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma: genetic association studies

Chen

Jiang

et al. 2009

Crit Care

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“…Clonorchis sinensis invades the bile duct in the liver where it stimulates epithelial cells and causes thickening of the wall and expansion of the biliary tract, resulting in chronic inflammation and structural (pathological) deformation of the biliary tract, thereby increasing the long-term risk of developing biliary cancer [ 2 , 11 , 12 ]. Ultrasonography is used to screen for chronic infection with C. sinensis as it can reveal pathological deformation of the liver and biliary tract [ 13 , 14 ]. Consistent with previous reports, we found that 84.7% of those infected with C. sinensis showed intrahepatic biliary dilatation.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Clonorchis sinensis Human Infections in Endemic Areas, Haman-Gun, Republic of Korea: A Case-Control Study

et al. 2020

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Clonorchis sinensis is the most common fish-borne intestinal parasite in Korea. The aim of the present investigation was to survey the status of C. sinensis infection and analyze associated risk factors in residents of Haman-gun, Gyeongsangnam-do. A total of 5,114 residents from 10 administrative towns/villages voluntarily agreed to participate in the study, which comprised fecal examination, a questionnaire survey for risk factors, ultrasonography, and enzymelinked immunosorbent assay for cancer biomarker detection in the blood. We detected C. sinensis eggs in 5.3% of the subjects. By region, Gunbuk-myeon had the highest number of residents with C. sinensis eggs. The infection rate and intensity were higher in male than in female residents. Based on the risk factor questionnaire, infection was highly associated with drinking, a history of C. sinensis infection, and the practice of eating of raw freshwater fish. Extension of the bile duct, infection intensity, and cancer biomarker detection significantly correlated with the presence of eggs in the study population. In conclusion, the development of feasible, long-term control policies and strategies for the elimination of C. sinensis in Korea is still required.

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“…Single nucleotide polymorphism (SNP) of IFN-␥ +874A/T (rs2430561) was genotyped using 5'-nuclease assay with allele-specific TaqMan probes as previously described. 20 SNPs of: IL-1␤ −511C/T (rs16944), IL-1␤ +3954C/T (rs1143634), IL12B 3'UTR A/C (rs3212227), and CCL2 −2518A/G (rs1024611), were assessed by PCR amplification and restriction fragment length polymorphism analysis, as previously reported. 13,[21][22][23] The presence of 32-base pair (bp) deletion within the CCR5 encoding gene (CCR5 32, rs333) and variable number of tandem (86-bp) repeats (VNTR) in the intron 2 of the IL-1RN gene (rs2234663) were analyzed by PCR.…”

Section: Cytokine Gene Polymorphism Analysismentioning

confidence: 99%

The impact of cytokine gene polymorphisms on Epstein–Barr virus infection outcome in pediatric liver transplant recipients

Kasztelewicz

Jankowska

Pawłowska

et al. 2012

Journal of Clinical Virology

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Single Nucleotide Polymorphisms of Cytokine Genes are Associated with Fibrosis of the Intrahepatic Bile Duct Wall in Human Clonorchiasis

Cited by 3 publications

References 14 publications

Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma: genetic association studies

Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma: genetic association studies

Risk Factors of Clonorchis sinensis Human Infections in Endemic Areas, Haman-Gun, Republic of Korea: A Case-Control Study

The impact of cytokine gene polymorphisms on Epstein–Barr virus infection outcome in pediatric liver transplant recipients

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