Single Nucleotide Polymorphisms in the Toll-Like Receptor 3 and CD44 Genes Are Associated with Persistence of Vaccine-Induced Immunity to the Serogroup C Meningococcal Conjugate Vaccine

Moore, Catrin E.; Hennig, Branwen J.; Perrett, Kirsten P.; Hoe, J. Claire; Lee, S J; Fletcher, Helen A.; Brocklebank, Denise; O’Connor, Daniel; Snape, Matthew D.; Hall, A. J.; Segal, Shelley; Avs., Hill; Pollarda, A J

doi:10.1128/cvi.05379-11

Cited by 17 publications

(11 citation statements)

References 31 publications

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“…One mechanism identified with variations in humoral (150,(174)(175)(176)(177)(178)(179)(180)(181)(182)(183)(184)(185)(186)(187)(188)(189)(190) and cellular (145,150,186,191) vaccine responses is polymorphism in major histocompatibility complex (MHC) genes (summarized in Table 3). Further genetic factors are polymorphisms in pattern recognition receptors (PRRs), such as Toll-like receptor (TLR) or RIG-like receptor (RLR) genes (192)(193)(194)(195) (Table 3). In addition, many single-nucleotide polymorphisms (SNPs) in other genes, for example, those coding for cytokines or cytokine, viral, or vitamin receptors, are also associated with variations in vaccine responses (182,190,192,193,(196)(197)(198)(199)(200)(201)(202)(203)(204)(205)(206)(207)(208)…”

Section: Lower Vaccine Responses In Neonates and Young Infantsmentioning

confidence: 99%

“…Further genetic factors are polymorphisms in pattern recognition receptors (PRRs), such as Toll-like receptor (TLR) or RIG-like receptor (RLR) genes (192)(193)(194)(195) (Table 3). In addition, many single-nucleotide polymorphisms (SNPs) in other genes, for example, those coding for cytokines or cytokine, viral, or vitamin receptors, are also associated with variations in vaccine responses (182,190,192,193,(196)(197)(198)(199)(200)(201)(202)(203)(204)(205)(206)(207)(208)(209)(210)(211) (Table 3). Further, different expression levels of genes also influence vaccine responses.…”

Section: Lower Vaccine Responses In Neonates and Young Infantsmentioning

confidence: 99%

“…Numerous studies have investigated vaccine responses in children with celiac disease (CD) (218-233) ( Table 4). Most found that children with CD have TIV: HLA-DRB1*07 (186) Higher antibody production MCV-C: TRL3 (193) Lower antibody production Measles: TLR3 (192) Variations in antibody production Diphtheria: IL-10 (196) HepB: FOXP1 (182), IL-4 (197), IL-4R (197), IL-10 promotor (198), IL-12B (196), TNF-␣ (196) TIV: IL-28B (199) Measles: CD46 (200,201), CD209 (200), IL-2 (202), IL-6 (192), IL-7R (203), IL-10 (202,203), IL-12RB (202)(203)(204), SLAM (201), TNF-␣ (192) MCV-C: CD44 (193) Mumps: IL-10RA, IL-12RB1 (150) PCV7/PPV23: IL-1␤ (196), IL-4 (205), IL-4R (196,205), IL-10 (196), IL-12RB1 (196), IL-13 (196,205) Rubella: CD209/DC-SIGN (206), IL-6 (206), leukocyte specific transcript 1 (190), lymphotoxin alpha (190,207), MOG (206), PVR (206), PVRL2 (206), RARB…”

Section: Lower Vaccine Responses In Neonates and Young Infantsmentioning

confidence: 99%

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Factors That Influence the Immune Response to Vaccination

2019

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SUMMARYThere is substantial variation between individuals in the immune response to vaccination. In this review, we provide an overview of the plethora of studies that have investigated factors that influence humoral and cellular vaccine responses in humans. These include intrinsic host factors (such as age, sex, genetics, and comorbidities), perinatal factors (such as gestational age, birth weight, feeding method, and maternal factors), and extrinsic factors (such as preexisting immunity, microbiota, infections, and antibiotics). Further, environmental factors (such as geographic location, season, family size, and toxins), behavioral factors (such as smoking, alcohol consumption, exercise, and sleep), and nutritional factors (such as body mass index, micronutrients, and enteropathy) also influence how individuals respond to vaccines. Moreover, vaccine factors (such as vaccine type, product, adjuvant, and dose) and administration factors (schedule, site, route, time of vaccination, and coadministered vaccines and other drugs) are also important. An understanding of all these factors and their impacts in the design of vaccine studies and decisions on vaccination schedules offers ways to improve vaccine immunogenicity and efficacy.

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Section: Lower Vaccine Responses In Neonates and Young Infantsmentioning

confidence: 99%

Section: Lower Vaccine Responses In Neonates and Young Infantsmentioning

confidence: 99%

Section: Lower Vaccine Responses In Neonates and Young Infantsmentioning

confidence: 99%

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Factors That Influence the Immune Response to Vaccination

2019

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“…Despite the numerous data demonstrating alteration of TLR mRNA expression by ligand activation, few reports demonstrated the consequence or specific mechanism by which TLRs themselves are transcriptionally regulated. In addition, the importance of TLR transcriptional regulation is highlighted by the fact that several single nucleotide polymorphisms in TLR promoters predispose humans to several autoimmune and chronic inflammatory diseases, including asthma and Crohn's disease (44)(45)(46)(47)(48)(49)(50)(51). In this article, we provided novel insights on the transcriptional regulation of TLR9 with dsDNA viruses.…”

Section: Discussionmentioning

confidence: 99%

TLR9 Transcriptional Regulation in Response to Double-Stranded DNA Viruses

Zannetti

Parroche

Panaye

et al. 2014

The Journal of Immunology

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The stimulation of TLRs by pathogen-derived molecules leads to the production of proinflammatory cytokines. Because uncontrolled inflammation can be life threatening, TLR regulation is important; however, few studies have identified the signaling pathways that contribute to the modulation of TLR expression. In this study, we examined the relationship between activation and the transcriptional regulation of TLR9. We demonstrate that infection of primary human epithelial cells, B cells, and plasmacytoid dendritic cells with dsDNA viruses induces a regulatory temporary negative-feedback loop that blocks TLR9 transcription and function. TLR9 transcriptional downregulation was dependent on TLR9 signaling and was not induced by TLR5 or other NF-κB activators, such as TNF-α. Engagement of the TLR9 receptor induced the recruitment of a suppressive complex, consisting of NF-κBp65 and HDAC3, to an NF-κB cis element on the TLR9 promoter. Knockdown of HDAC3 blocked the transient suppression in which TLR9 function was restored. These results provide a framework for understanding the complex pathways involved in transcriptional regulation of TLR9, immune induction, and inflammation against viruses.

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“…However, given the low sensitivity of these assays, it is possible that TLR signaling may be occurring and not detected through standard assays. Of note, Moore et al have recently identified that SNPs in TLR3 and CD44 genes are associated with persistence of antibody to serogroup C meningococcal conjugate vaccine in a cohort of healthy children aged 6 to 12 years (18). TLR3 recognizes double-stranded RNA through the N-terminal ectodomains; thus, how TLR3 might alter long-term antibody response to meningococcal vaccines is similarly unclear.…”

Section: Discussionmentioning

confidence: 99%

Genetic Variants in Toll-Like Receptor 2 (TLR2), TLR4, TLR9, and FCγ Receptor II Are Associated with Antibody Response to Quadrivalent Meningococcal Conjugate Vaccine in HIV-Infected Youth

Spector

Qin

Luján-Zilbermann

et al. 2013

Clin Vaccine Immunol

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Response was defined as a >4-fold increase from entry in bactericidal antibody titers to each serogroup. Generalized estimating equation (GEE) models were used to evaluate the association of allelic variants with the immunologic response to all serogroups within each subject with and without adjusting for CD4 percentage and HIV viral load. At week 4, but not after, subjects with TLR2-2408-G/A versus -G/G genotypes and the TLR4-12874-A/A genotype were more likely to achieve a >4-fold increase overall in the four serogroups (unadjusted P of 0.006 and adjusted P of 0.008 and unadjusted P of 0.008 and adjusted P of 0.019, respectively). At week 28, the TLR9-1237 T allele was associated with enhanced antibody response (T allele versus C/C, unadjusted P of 0.014 and adjusted P of 0.009), which was maintained at week 72 (unadjusted and adjusted P of 0.008). At week 72, the Fc␥RII-131Arg allotype was associated with a >4-fold increase in antibody titer versus those with His/His (unadjusted P of 0.009; adjusted P of <0.001). These findings suggest that for HIV-infected youth, the initial antibody response to MCV4 is associated with variants in TLR2 and TLR4 while the long-term response is associated with genetic polymorphisms in TLR9 and Fc␥RIIa.

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Single Nucleotide Polymorphisms in the Toll-Like Receptor 3 and CD44 Genes Are Associated with Persistence of Vaccine-Induced Immunity to the Serogroup C Meningococcal Conjugate Vaccine

Cited by 17 publications

References 31 publications

Factors That Influence the Immune Response to Vaccination

Factors That Influence the Immune Response to Vaccination

TLR9 Transcriptional Regulation in Response to Double-Stranded DNA Viruses

Genetic Variants in Toll-Like Receptor 2 (TLR2), TLR4, TLR9, and FCγ Receptor II Are Associated with Antibody Response to Quadrivalent Meningococcal Conjugate Vaccine in HIV-Infected Youth

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