Single Nucleotide Polymorphisms in SLC5A1, CCNA1, and ABCC1 and the Association with Litter Size in Small-Tail Han Sheep

La, Yongfu; Liu, Qiuyue; Zhang, Liping; Chu, Mingxing

doi:10.3390/ani9070432

Cited by 9 publications

(4 citation statements)

References 54 publications

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“…With the development of modern breeding technology and breeding industry, we wanted to explore a useful and efficient way to promote goat growth traits and enhance economic performance. Many studies have confirmed that polymorphisms of some candidate genes could be associated with economic traits in livestock [5][6][7]. Van Laere found that a G to A nucleotide mutation appeared in intron 3 of porcine IGF2, which abolishes BED-type containing 6 repressor (a kind of transcription factor) binding and affected pig meat production [8].…”

Section: Introductionmentioning

confidence: 98%

Screening of Deletion Variants within the Goat PRDM6 Gene and Its Effects on Growth Traits

Wang

Guo

et al. 2020

Animals

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Simple Summary: Genome-wide association studies found that the PR/SET Domain 6 (PRDM6) gene mutation was associated with bone development, bone density, and body mass index. This study found a 12 bp deletion variation within the PRDM6 gene in Shaanbei white cashmere goats in a large sample size (n = 1044). This variation polymorphism was associated with multiple goat growth traits in the yearling period, including heart girth (p = 0.027), cannon circumference (p = 0.008), chest depth (p = 2.10 × 10 −5 ), chest width (p = 0.004), body height (p = 0.032), body length (p = 0.044), and hip-width (p = 0.014). The effects of the 12 bp variation were found to make no difference on adult goat growth traits. Taken together, these results demonstrate that the 12 bp deletion variant plays an important role in the early growth and development of goats and could be considered as a useful and effective molecular marker for goat breeding selection in the growth stage.Abstract: By genome-wide association studies, the PRDM6 gene has been shown to affect multiple, apparently unrelated inherited traits, including bone density and body mass index. Therefore, it is considered a potentially pleiotropic gene. In this study, we identified a 12 bp deletion variant (NC_030814.1:rs651603667, g: 79985625-79985636delTTGACTGATCCA) within the PRDM6 gene in a large sample (SBWC goats; n = 1044). All goat samples were collected in Shaanxi province in July 2018. The frequency of the wt allele was higher than the frequency of the del allele, and this mutation polymorphism confirmed to be consistent with the Hardy-Weinberg equilibrium (p > 0.05). Further results showed that in a group of goats in the yearling period (18 months old, n = 567), this deletion variant of the PRDM6 gene was associated with heart girth (p = 0.027), cannon circumference (p = 0.008), chest depth (p = 2.10 × 10 −5 ), chest width (p = 0.004), body height (p = 0.032), body length (p = 0.044) and hip-width (p = 0.014). For adult SBWC goats (36 months old, n = 477), the effects of the 12 bp variation on growth-related traits were found to make no difference. These findings show that the 12 bp deletion within the goat PRDM6 gene plays an important role in the early growth and development of goats. Using the 12 bp mutation, breeders can quickly and effectively select excellent individual goats at an early stage.

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Section: Introductionmentioning

confidence: 98%

Screening of Deletion Variants within the Goat PRDM6 Gene and Its Effects on Growth Traits

Wang

Guo

et al. 2020

Animals

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“…Thus, to establish optimal breeding programs, plenty of candidate genes, as well as their genetic variations should be appropriately used [4][5][6][7]. Maker-assisted selection (MAS) can satisfy the need to screen crucial genes and consider the relation between their polymorphisms and growth-related traits [8][9][10][11]. Herein, establishing a MAS system and performing candidate genes analyses will speed up the development of goat breeding [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Myostatin (MSTN) Gene Indel Variation and Its Associations with Body Traits in Shaanbei White Cashmere Goat

Feng

Wang

et al. 2020

Animals

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Myostatin (MSTN) gene, also known as growth differentiation factor 8 (GDF8), is a member of the transforming growth factor-beta super-family and plays a negative role in muscle development. It acts as key points during pre- and post-natal life of amniotes that ultimately determine the overall muscle mass of animals. There are several studies that concentrate on the effect of a 5 bp insertion/deletion (indel) within the 5’ untranslated region (5’ UTR) of goat MSTN gene in goats. However, almost all sample sizes were below 150 individuals. Only in Boer goats, the sample sizes reached 482. Hence, whether the 5 bp indel was still associated with the growth traits of goats in large sample sizes which were more reliable is not clear. To find an effective and dependable DNA marker for goat rearing, we first enlarged the sample sizes (n = 1074, Shaanbei White Cashmere goat) which would enhance the robustness of the analysis and did the association analyses between the 5 bp indel and growth traits. Results uncovered that the 5 bp indel was significantly related to body height, height at hip cross, and chest width index (p < 0.05). In addition, individuals with DD genotype had a superior growing performance than those with the ID genotype. These findings suggested that the 5 bp indel in MSTN gene are significantly associated with growth traits and the specific genotype might be promising for maker-assisted selection (MAS) of goats.

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“…Among the candidate genes in ROH, associated with the "Oxytocin signaling pathway" and "Calcium signaling pathway" metabolic pathways, is the ITPR1 (Inositol 1,4,5-trisphosphate receptor Type 1) gene. It contributes to endocrine control [62] and acts on GnRH, estrogen, oxytocin, and TGF-beta signaling pathways [63]. The CACNB2 (Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2) gene is associated to ion channel function, which acts on uterine contraction during labor in humans [64].…”

Section: Functional Annotation Of Roh In Prolific Sheepmentioning

confidence: 99%

Runs of Homozygosity and Gene Identification in Pelibuey Sheep Using Genomic Data

et al. 2022

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The runs of homozygosity (ROHs), the inbreeding coefficient, and the effective population size (Ne) in Pelibuey sheep were analyzed in 24 Pelibuey ewes from two lambs at parturition and 24 ewes that gave birth to a single lamb using the Ilumina OvineSNP50 BeadChip. The Ne decreased from 535 to 192 in the first ten generations. A total of 2194 ROHs were identified on the basis of single nucleotide polymorphisms (SNPs), were identified in the prolific group and 2185 SNPs in ROH in the non-prolific group. The distribution of the lengths of the ROH, considering both groups, were found to be: 4065 less than 6 Mb, 213 between 6 and 12 Mb, 72 between 12 and 24 Mb, twenty between 24 and 48 Mb and 8 greater than 48 Mb. In prolific sheep, the ROH associated with prolificacy were identified near the LINGO2, FLRT2, ADGRB3 genes, related to “positive regulation of synapse assembly”; and the DGKG, DGKE, DGKB and DGKI genes, related to “protein kinase C-activating G-protein coupled receptor signaling pathway”. The present work present genes that can function as signal mediators or have activity in embryonic development, which is relevant to the economic activity of this species.

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Single Nucleotide Polymorphisms in SLC5A1, CCNA1, and ABCC1 and the Association with Litter Size in Small-Tail Han Sheep

Cited by 9 publications

References 54 publications

Screening of Deletion Variants within the Goat PRDM6 Gene and Its Effects on Growth Traits

Screening of Deletion Variants within the Goat PRDM6 Gene and Its Effects on Growth Traits

Myostatin (MSTN) Gene Indel Variation and Its Associations with Body Traits in Shaanbei White Cashmere Goat

Runs of Homozygosity and Gene Identification in Pelibuey Sheep Using Genomic Data

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