Single nucleotide polymorphisms in intron 1 and intron 2 of Larimichthys crocea growth hormone gene are correlated with growth traits

Ni, Jian; Feng, Yu; Xu, Jianhe; Xu, Dongdong; Wen, Aiyun; Wu, Zhihao; Xu, Yide; Zhang, Peijun

doi:10.1007/s00343-012-1078-y

Cited by 11 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Growth traits including growth rate, body weight and length are the most important traits in aquaculture species [ 6 ]. Growth hormone ( GH ), a major factor in regulating growth of vertebrates, has been considered as a candidate gene associated with linear growth, food conversion and appetite in fish [ 7 – 9 ]. To date, polymorphisms in the GH gene have been reported and some SNPs have been revealed to be associated with economic traits in several fishes, such as brown trout [ 10 ], chinook salmon [ 11 ], bleak [ 12 ], Atlantic salmon [ 13 ], common bream [ 14 ], and large yellow croaker [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in Growth Hormone Gene and Their Association with Growth Traits in Siniperca chuatsi (Basilewsky)

Tian

Yang

et al. 2014

IJMS

View full text Add to dashboard Cite

Growth hormone (GH) has been considered as a candidate gene for growth traits in fish. In this study, polymorphisms of the GH gene were evaluated for associations with growth traits in 282 Siniperca chuatsi individuals. Using directly sequencing, four single nucleotide polymorphisms (SNPs) were identified in GH gene, with two mutations in intron 4 (g.4940A>C, g.4948A>T), one mutation in exon 5 (g.5045T>C) and one in intron 5 (g.5234T>G). Notably, three of them were significantly associated with growth performance, particularly for g.4940A>C which was highly correlated with all the four growth traits. In conclusion, our results demonstrated that these SNPs in GH gene could influence growth performance of S.chuatsi and could be used for marker-assisted selection (MAS) in this species.

show abstract

Section: Introductionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in Growth Hormone Gene and Their Association with Growth Traits in Siniperca chuatsi (Basilewsky)

Tian

Yang

et al. 2014

IJMS

View full text Add to dashboard Cite

show abstract

“…Forty-three SNPs on growth-related genes were selected based on QTL co-localization in a wild Atlantic population. SNPs in growth hormone gene of large yellow croaker L. crocea was correlated with growth traits (Ni et al, 2012).…”

Section: Growth Traitsmentioning

confidence: 99%

Single nucleotide polymorphism markers with applications in aquaculture and assessment of its impact on natural populations

Wenne

2017

Aquat. Living Resour.

View full text Add to dashboard Cite

-An increase in aquatic animal production can be achieved by extending aquaculture areas geographically, utilizing new species for culture, and using new technologies. Among new technologies useful for the increase of aquaculture production is the application of genetics and genomics. New molecular tools that benefit aquaculture have been developed. There has been a large number of experimental and review papers published concerning molecular markers and the range of their applications, including aquaculture and food product analyses. Analysis of single nucleotide polymorphisms (SNPs) has emerged as genotyping technology with wide and significant applications in aquaculture. SNPs can be used for construction of genetic linkage maps, finding quantitative trait loci (QTL) for useful traits like growth, body weight, grilsing, thermal and low oxygen tolerance, resistance to stress and diseases, mapping sex determination loci and identification of progeny in selection and chromosome manipulation experiments, assessment of genomic selectionand marker assisted selection in aquaculture. Genome-wide association studies (GWAS) facilitate the finding associations between SNPs and a trait in related or unrelated specimens. However, many traits are complex and can be controlled by number of QTL. Genotyping by genome reduction complexity sequencing emerged as an efficient and applicable technology in genomic selection. Identification of genes, sequences and nucleotides (substitutions) directly influencing phenotypic variations opens the possibility of marker-assisted selection for desirable characters in culture. SNP and QTL associations can be enhanced using genome editing technology. Examples of successful applications of SNPs in aquaculture of fish, crustacean and mollusk species, representing most geographic areas, and ecological risks assessment are reviewed.

show abstract

“…Genetic variations in growth-related genes have shown significant correlation with growth performance in different fish species, including prolactin gene of Asian seabass: Lates calcarifer (Bloch, 1790) (He, Xia, Wang, Pang, & Yue, 2011), and GH gene of large yellow croaker: Larimichthys crocea (Richardson, 1846) (Ni et al, 2012).…”

mentioning

confidence: 99%

Single nucleotide polymorphisms in the growth hormone gene ofOreochromis niloticusand their association with growth performance

et al. 2017

View full text Add to dashboard Cite

Polymorphisms in the growth hormone (GH) gene that is associated with the growth rate of farmed fish have been the target of many breeding programmes. The present study aimed to identify single nucleotide polymorphisms (SNPs) in GH gene regions to evaluate the association of SNP variations with the growth rate of two Nile tilapia: Oreochromis niloticus (Linnaeus, 1758) strains. The targeted regions were amplified, sequenced, aligned and screened for the presence of SNPs; thereafter, performance tests were used to check for the association between SNPs and weight. Allele and genotype frequencies were estimated for each SNP and genotype. Genotype blocks or sets of SNP genotypes and frequencies were also estimated. Association between SNPs and growth rate was statistically evaluated using a univariate linear mixed model that included both fixed and random effects. A total of 10 SNPs were identified, nine in the proximal promoter and one located in the 5′ UTR, forming 10 genotype blocks. In all weight recordings, five genotype blocks were significantly associated with the highest weights. Single nucleotide polymorphisms 6‐10 were also found to be significantly associated with growth (p‐value < .05). Genotypes with higher additive genetic values for weight were identified in the Chitralada strain, suggesting a possible impact of these additive effects of the GH SNP genotype on the growth rate of Nile tilapia. These findings may be used as part of marker‐assisted selection in tilapia breeding programmes.

show abstract

Single nucleotide polymorphisms in intron 1 and intron 2 of Larimichthys crocea growth hormone gene are correlated with growth traits

Cited by 11 publications

References 25 publications

Single Nucleotide Polymorphisms in Growth Hormone Gene and Their Association with Growth Traits in Siniperca chuatsi (Basilewsky)

Single Nucleotide Polymorphisms in Growth Hormone Gene and Their Association with Growth Traits in Siniperca chuatsi (Basilewsky)

Single nucleotide polymorphism markers with applications in aquaculture and assessment of its impact on natural populations

Single nucleotide polymorphisms in the growth hormone gene ofOreochromis niloticusand their association with growth performance

Contact Info

Product

Resources

About