Single nucleotide polymorphisms in interleukin-1gene cluster and subgingival colonization with Aggregatibacter actinomycetemcomitans in patients with aggressive periodontitis

Schulz, Susanne; Stein, J.; Altermann, Wolfgang; Klapproth, Jana; Zimmermann, Uta; Reichert, Yvonne; Gläser, Christiane; Schaller, Hans‐Günter; Reichert, Stefan

doi:10.1016/j.humimm.2011.05.009

Cited by 25 publications

(34 citation statements)

References 39 publications

(58 reference statements)

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“…But Nibali et al [42] also suggested that only a detection of known periodontopathogenic bacteria could not discriminate different forms of periodontitis. In contrast, Schulz et al [43] found no evidence that SNPs in IL1 gene cluster could be associated with subgingival colonization with A. actinomycetemcomitans and could thus be an independent risk indicator of AgP. In addition, Finoti et al [44] observed that periodontal destruction may occur in patients who are considered to be genetically susceptible to CP with a lower microbial challenge because of the presence of the IL8 ATC/TTC haplotype than in patients without this haplotype.…”

Section: Discussionmentioning

confidence: 99%

Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis

Linhartová

Vokurka

Poskerová

et al. 2013

Mediators of Inflammation

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Objectives. Periodontitis is an inflammatory disease characterized by connective tissue loss and alveolar bone destruction. Interleukin-8 (IL8) is important in the regulation of the immune response. The aim of this study was to analyze four polymorphisms in the IL8 gene in relation to chronic (CP) and aggressive (AgP) periodontitis. Methods. A total of 492 unrelated subjects were included in this case-control association study. Genomic DNA of 278 patients with CP, 58 patients with AgP, and 156 controls were genotyped, using the 5′ nuclease TaqMan assay, for IL8 (rs4073, rs2227307, rs2227306, and rs2227532) gene polymorphisms. Subgingival bacterial colonization was investigated by the DNA-microarray detection kit in a subgroup of subjects (N = 247). Results. Allele and genotype frequencies of all investigated IL8 polymorphisms were not significantly different between the subjects with CP and/or AgP and controls (P > 0.05). Nevertheless, the A(−251)/T(+396)/T(+781) and T(−251)/G(+396)/C(+781) haplotypes were significantly less frequent in patients with CP (2.0% versus 5.1%, P < 0.02, OR = 0.34, 95% CI: 0.15–0.78, resp., 2.0% versus 4.5%, P < 0.05, OR = 0.41, 95% CI: 0.18–0.97) than in controls. Conclusions. Although none of the investigated SNPs in the IL8 gene was individually associated with periodontitis, some haplotypes can be protective against CP in the Czech population.

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Section: Discussionmentioning

confidence: 99%

Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis

Linhartová

Vokurka

Poskerová

et al. 2013

Mediators of Inflammation

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“…Twenty publications with sufficient data were collected in our meta-analysis [15,21–39]. Out of these 20 articles, 8 case-control studies with 522 cases and 683 controls described the association between IL-1β −511C>T polymorphism and AgP risk [15,23,25,27,30,32–34], and 22 case-control studies involving 965 cases and 1234 controls focused on the relationship of IL-1β +3954C>T polymorphism and AgP susceptibility [15, 21–39]. Only 2 studies deviated from the finding of HWE in IL-1β +3954C>T polymorphism [35,37].…”

Section: Resultsmentioning

confidence: 99%

“…Eight related publications (522 cases and 683 controls) reported on the association between IL-1β −511C>T polymorphism and AgP risk [15,23,25,27,30,32–34]. Three studies described Asian populations [15,25,32], and 5 studies described white populations [23,27,30,33,34].…”

Section: Resultsmentioning

confidence: 99%

“…Three studies described Asian populations [15,25,32], and 5 studies described white populations [23,27,30,33,34]. Overall, no significant association between IL-1β −511C>T polymorphism and AgP risk was found in this meta-analysis [T vs. C: OR=1.069, 95% CI=0.901–1.268, P =0.443, I 2 =0%; CT vs. CC: OR=0.921, 95% CI=0.699–1.212, P =0.556, I 2 =8.9%; TT vs. CC: OR=1.064, 95% CI=0.747–1.515, P =0.732, I 2 =5.6%; CT+TT vs. CC: OR=0.990, 95% CI=0.764–1.283, P =0.938, I 2 =3.9%; TT vs. CC+CT: OR=1.229, 95% CI=0.919–1.643, P =0.164, I 2 =0.0%].…”

Section: Resultsmentioning

confidence: 99%

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Association between Interleukin-1β Gene –511C>T/+3954C>T Polymorphisms and Aggressive Periodontitis Susceptibility: Evidence from a Meta-Analysis

Liu

Jiang

et al. 2015

Med Sci Monit

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BackgroundInterleukin-1β (IL-1β) is an important inflammatory cytokine. The associations between IL-1β gene −511C>T/+3954C>T polymorphisms and aggressive periodontitis (AgP) susceptibility have been conflicting. We therefore conducted a meta-analysis to investigate the association of IL-1β genetic polymorphisms with susceptibility to AgP.Material/MethodsPubMed and Embase electronic databases were searched for relevant studies. Odds ratios (ORs) with 95% confidence interval (CIs) were used to assess the association between IL-1β polymorphisms and AgP risk. Heterogeneity, publication bias, and sensitivity analysis were performed to guarantee the statistical power.ResultsTwenty published studies involving 965 patients and 1234 control subjects were included. No significant association between IL-1β polymorphisms and AgP was found. For −511C>T (T vs. C: OR=0.966, 95%CI=0.696–1.341, P=0.869; CT vs. CC: OR=0.936, 95%CI=0.761–1.151; TT vs. CC: OR=0.892, 95%CI=0.464–1.715, P=0.719; CT+TT vs. CC: OR=1.026, 95%CI=0.795–1.323; TT vs. CC+CT: OR=0.864, 95%CI=0.436–1.713). For +3954C>T (T vs. C: OR=1.069, 95%CI=0.901–1.268; CT vs. CC: OR=0.921, 95%CI=0.699–1.212; TT vs. CC: OR=1.064, 95%CI=0.747–1.515; CT+TT vs. CC: OR=0.990, 95%CI=0.764–1.283; TT vs. CC+CT: OR=1.229, 95%CI=0.919–1.643). Subgroup analyses were conducted with HWE, ethnicity, and study design, and no significant association was detected.ConclusionsThese results demonstrate that IL-1β −511C>T and +3954C>T polymorphisms are not the risk factors for developing AgP.

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“…Those problems include neonatal onset of sterile multifocal osteomyelitis, periostitis, and pustulosis [9], neonatal onset of pustular rash, osteopenia, lytic bone lesions, respiratory insufficiency, and thrombosis [10], generalized aggressive periodontitis [11,12], refractory adult-onset Still’s disease [13], coronary artery disease [14], schizophrenia [15], and risk of gastric cancer [16] and early stages of gastric carcinogenesis [17]. …”

Section: Il-1 Receptor Antagonist Human Diseases and Pharmaceutimentioning

confidence: 99%

Anakinra as an interleukin 1 receptor antagonist, complicated genetics and molecular impacts- from the point of view of mouse genomics

Cao

Jiao

Wang

et al. 2012

International Immunopharmacology

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IL-1 receptor antagonist (IL-1rn) is a protein that binds to IL-1 receptors (IL-1r1) and inhibits the binding of IL-1α and IL-1β. In recent years, IL-1rn has been implicated to be associated with many human health problems. The effects of treatment of several inflammatory disorders with anakinra, which is an interleukin-1 (IL-1) receptor antagonist, have also been reported. Both positive and negative effects have been described. In this review, we systematically analyzed the expression, correlation, and regulation of IL-1rn and its 13 partner genes using available gene expression profiles from a variety of tissues in a well known transcriptome database, Genenetwork. The 13 partner genes include IL-1r1, IL-1β, IL-1α, Myd88, Irak1, Irak2, Irak4, Traf6, Tlr4, IL-1rap, Ikbkap, Nfkb1, and Nfkb2. Gene expression profiles are from 10 tissues including spleen, kidney, lung, whole brain, eye, prefrontal cortex, cerebellum, hippocampus, striatum, and nucleus accumbens. Our analysis indicated that the interactions among IL-1rn and its partner are complex and different from tissues to tissues, suggesting a broad spectrum of the effect of IL-1rn on biological and metabolic pathways. Transcripts and protein sequences resulted from different splicing, interaction with genomic background of individuals, and environmental factors affect function of IL-1rn. At present, our knowledge on the function of IL-1rn and its partner in various tissues or organs is very limited. The long term and extended effect of anakinra on human health needs further investigations. In the future, targeted sequences or oligos of Il-1rn might be ideal for therapeutic application with less toxic and more specific in the treatment of specific disease. Detailed study on the molecular function of IL-1rn and its interaction with other genes and environmental factors is essential for development therapeutic application using IL-1rn.

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Single nucleotide polymorphisms in interleukin-1gene cluster and subgingival colonization with Aggregatibacter actinomycetemcomitans in patients with aggressive periodontitis

Cited by 25 publications

References 39 publications

Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis

Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis

Association between Interleukin-1β Gene –511C>T/+3954C>T Polymorphisms and Aggressive Periodontitis Susceptibility: Evidence from a Meta-Analysis

Anakinra as an interleukin 1 receptor antagonist, complicated genetics and molecular impacts- from the point of view of mouse genomics

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