Single nucleotide polymorphisms in 5-HT receptors in the etiology of premature ejaculation

Sonkurt, Melis Danışman; Güleç, Gülcan; Coşan, Didem Turgut; Çalış, İbrahim Uğur; Mutlu, Fezan; Üre, İyimser; Sonkurt, Harun Olcay

doi:10.1016/j.androl.2021.02.009

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“…In our previous study, 13 genes (LACTBL1, SSBP3 and ACOT11) were found to be significantly associated with LPE risk in Chinese male Han population by genome-wide association analysis [ 22 ]. It was also reported that the genetic variation of 5-HT1B rs11568817 and 5-HT2C rs518147 were significantly associated with the occurrence of PE [ 27 ]. In this study, we investigated whether TPH2 and HTR1A gene polymorphisms in the 5-HT regulatory system are potentially associated with LPE susceptibility.…”

Section: Discussionmentioning

confidence: 99%

Influence of TPH2 and HTR1A polymorphisms on lifelong premature ejaculation risk among the chinese Han population

et al. 2023

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Background Lifelong premature ejaculation (LPE) is one of the most common ejaculatory dysfunctions in men. The serotonin (5-HT) synthesis rate-limiting enzyme (TPH2) and receptor (HTR1A) in the 5-HT regulatory system may play a key role in the pathogenesis of LPE. However, there are few studies on the effects of TPH2 and HTR1A polymorphisms on LPE risk. We speculated that TPH2 and HTR1A polymorphisms may affect the occurrence and development of LPE in the Chinese Han population. Methods In this study, 91 patients with LPE and 362 normal controls aged 18 to 64 years were enrolled in the male urology department of Hainan General Hospital in China from January 2016 to December 2018. The SNPs in HTR1A and TPH2, which are related to 5-HT regulation, were selected as indexes to genotype the collected blood samples of participants. Logistic regression was used to analyze the correlation between SNPs of HTR1A and TPH2 with LPE susceptibility, as well as the relationship with leptin, 5-HT and folic acid levels. Results The results revealed that HTR1A-rs6295 increased LPE risk in recessive model. Rs11178996 in TPH2 significantly reduced susceptibility to LPE in allelic (odds ratio (OR) = 0.68, 95% confidence interval (95% CI) = 0.49–0.96, p = 0.027), codominant (OR = 0.58, 95% CI = 0.35–0.98, p = 0.040), dominant (OR = 0.58, 95% CI = 0.36–0.92, p = 0.020), and additive (OR = 0.71, 95% CI = 0.52–0.98, p = 0.039) models. Grs11179041Trs10879352 could reduce the risk of LPE (OR = 0.44, 95% CI = 0.22–0.90, p = 0.024) by haplotype analysis. Conclusion HTR1A-rs6295 and TPH2-rs11178996 are associated with LPE risk in the Chinese Han population based on the finding of this study.

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Section: Discussionmentioning

confidence: 99%