Single nucleotide polymorphisms associated with non-contact soft tissue injuries in elite professional soccer players: influence on degree of injury and recovery time

Pruna, Ricard; Artells, Rosa; Ribas, Jordi; Montoro, Bruno; Cos, Francesc; Muñoz, Carme; Rodas, Gil; Maffulli, Nicola

doi:10.1186/1471-2474-14-221

Cited by 68 publications

(129 citation statements)

References 56 publications

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“…The first study [15] was performed with DNA obtained from a population of 73 elite players. The number and classification of noncontact muscle, tendon and ligament injuries occurring over 3 consecutive seasons was recorded.…”

Section: Genetics and Injury Occurrencementioning

confidence: 99%

Influence of Genetics on Sports Injuries

Pruna¹,

Clos²,

Bahdur³

et al. 2017

J Nov Physiother

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SummaryThe identification of risk factors and the assessment of athlete's predisposition to suffer an injury and the way in which it will occur is hard to predict due to the multifactorial origin of the lesions. In recent years, the importance of the genetic component of each individual as a possible cause of injury predisposition is being evaluated.The objective of this work was to write a review of the genetic studies carried out to date on connective tissue injuries and propose future research lines that would allow the development of more personalized training programs and specify preventive therapies in order to reduce the injury risk.The multifactorial origin of injuries complicates the identification of risk factors (extrinsic and intrinsic factors). Together, these factors and their interaction predisposes an athlete to injuries. In recent years, the genetic component of each individual as a possible cause of injury predisposition has become of importance.The aim of this article was to propose a review of published genetic studies related to connective tissue repair or regeneration and to pave the way for future Sports Medicine Research. This information could be very useful in order to individualize the preventive strategies to avoid injuries and to optimize the therapeutic and rehabilitation process after injuries.Applied biology is already contributing new knowledge by providing new biomarkers that will give information and increase understanding regarding the susceptibility of individuals to suffer certain types of injury. Genetic analysis can offer us reliable and objective predictive parameter that combined with the current methods of analysis will help improve the performance and management of athletes.

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Section: Genetics and Injury Occurrencementioning

confidence: 99%

Influence of Genetics on Sports Injuries

Pruna¹,

Clos²,

Bahdur³

et al. 2017

J Nov Physiother

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“…Although professional soccer players followed a similar trend with GG having a slight increase in injury and decrease in matches, this did not reach significance. Previously, Pruna et al (Pruna et al, 2013) has shown that individuals with the GA genotype had less severe injuries than either GG or AA genotypes. We have also shown that the GG genotype is associated with more injuries than even the AA genotype.…”

Section: Discussionmentioning

confidence: 99%

Can Genetics Predict Sports Injury? The Association of the Genes GDF5, AMPD1, COL5A1 and IGF2 on Soccer Player Injury Occurrence

McCabe¹,

Collins²

2018

Preprint

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Genetics plays an integral role in athletic performance and is increasingly becoming recognised as an important risk factor for injury. Ankle and knee injuries are the most common injuries sustained by soccer players. Often these injuries result in players missing training and matches, which can incur significant costs to clubs. This study aimed to identify genotypes associated with ankle and knee injuries in soccer players and how these impacted the number of matches played. 289 soccer players including 46 professional, 98 semiprofessional and 145 amateur players were genetically tested. Ankle and knee injuries and the number of matches played were recorded during the 2014/15 season. Four genes were assessed in relation to injury. Genotypes found to be associated with injury included the TT genotype of the GDF5 gene, TT and CT genotypes of AMPD1 gene, TT genotype of COL5A1 and GG genotype of IGF2 gene. These genes were also associated with a decrease in the number of matches played.

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“…All these studies show that there is a marked genetic influence in the nature of an injury 15 , higher than 50% 13,16 . The genetics characteristic of players may also provide information regarding this predisposition of MCL to tear [17][18][19] . Ligaments are composed of approximately two thirds of water 20 .…”

Section: Original Articlementioning

confidence: 99%

“…In the terminal region of ligaments, the orientation of the collagen fibrils is longitudinal, and the elastic fibres end within the ligament without any attachment to bone 23 . The presence of single nucleotide polymorphisms (SNPs) in some of these components has been associated with ligament injuries [17][18][19] . A SNP can occur both in the coding and non-coding regions of a gene, and can affect the response of an individual to a specific treatment or other stimuli 24 .…”

Section: Original Articlementioning

confidence: 99%

Elastin: a possible genetic biomarker for more severe ligament injuries in elite soccer. A pilot study

Artells

Pruna

Dellal

et al. 2016

MLTJ

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SummaryBackground: The study of new genetic biomarkers in genes related to connective tissue repair and regeneration may help to identify individuals with greater predisposition to injury, who may benefit from targeted preventive measures, and those who require longer recovery time following a muscle, ligament or tendon injury. The present study investigated whether single nucleotide polymorphisms of the Elastin gene could be related to MCL injury. Methods: 60 top class football players were studied to identify single nucleotide polymorphisms for the Elastin (ELN) gene using Allelic Discrimination analysis. Each player was followed for 7 seasons, and each MCL injury was noted. Results: Ligament injury rate, severity and recovery time are related to specific genotypes observed in the elastin gene, especially the ELN-AA (16 MCL) and the ELN-AG (3 MCL). Players with the ELN-GG genotype sustained no MCL injury during the 7 seasons of the study. Conclusions: The identification of polymorphisms in the ELN gene may be used as a novel tool to better define an athlete's genotype, and help to plan training and rehabilitation programmes to prevent or minimize MCL ligament injuries, and optimize the therapeutic and rehabilitation process after soft tissue injuries, and manage the workloads during trainings and matches.

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Single nucleotide polymorphisms associated with non-contact soft tissue injuries in elite professional soccer players: influence on degree of injury and recovery time

Cited by 68 publications

References 56 publications

Influence of Genetics on Sports Injuries

Influence of Genetics on Sports Injuries

Can Genetics Predict Sports Injury? The Association of the Genes GDF5, AMPD1, COL5A1 and IGF2 on Soccer Player Injury Occurrence

Elastin: a possible genetic biomarker for more severe ligament injuries in elite soccer. A pilot study

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