Single Nucleotide Polymorphisms and Risk of Oral Cancer: Indian Case-Control Study

Multania, Shaleen; Saranath, Dhananjaya

doi:10.4172/2155-9899.1000448

Cited by 6 publications

(5 citation statements)

References 48 publications

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“…The human genome houses SNP which predicts the possibility of encountering cancer at any time in life . Our research found an association between SNP of survivin and OSCC (Tanaka and Ishigamori, 2011;Multania and Saranath, 2016;Shojaei et al, 2018). Various studies showed that survivin -31G/C polymorphism was positively correlated with the development and aggressiveness of urothelial, colorectal, gastric, lung, breast, and oral carcinomas (do Nascimento Borges et al, 2011;Jang et al, 2008).…”

Section: Discussionsupporting

confidence: 56%

Survivin Promoter Polymorphism (-31 C/G): A Genetic Risk Factor for Oral Cancer

Mehdi

Sheikh

Khan

et al. 2019

Asian Pac J Cancer Prev

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Section: Discussionsupporting

confidence: 56%

Survivin Promoter Polymorphism (-31 C/G): A Genetic Risk Factor for Oral Cancer

Mehdi

Sheikh

Khan

et al. 2019

Asian Pac J Cancer Prev

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“…Similarly, heterozygous genotypes of SNPs rs1800870-AG in the IL-10 gene, rs11549467-GA in the HIF gene, and rs861539-CT in the XRCC3 genes were linked to an increased risk of oral cancer, while WT genotypes were linked to a lower risk. The WT genotypes rs1801133-CC in MTHFR and rs20417-GG in COX-2, on the other hand, were related with an increased risk, while the corresponding SNP homozygous genotypes TT and CC were associated with a decreased risk [67].…”

Section: Single Nucleotide Polymorphisms (Snps)mentioning

confidence: 94%

Personalised Precision Medicine - A Novel Approach for Oral Cancer Management

Patil¹,

Rakesh²

2022

Oral Cancer - Current Concepts and Future Perspectives

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Oral Cancer is one of the most common malignancies of the head and neck region. Despite technological advancements and improvements in Oral cancer diagnosis and treatment modalities, the 5-year survival rate remains low and is associated with poor prognosis and high mortality rate especially when detected at a later stage. The empirical therapy followed for the treatment of oral cancer includes surgery, radiotherapy and chemotherapy. The treatments are not equally efficacious for all patients, are associated with side effects and poor prognosis. The need of the hour is early diagnosis and tailored treatment therapies for individual patients. With the advent of immunotherapy, the cancer treatment has moved toward personalised precision medicine which tailors’ treatments to each individual. Personalised precision medicine incorporates, molecular profiling of tumours with OMICS technology, biomarkers and companion diagnostics to build databases of patients and devise tailor made treatment approaches for individual patients. This article discusses the role of precision medicine in OSCC prevention, detection, and management by reviewing our understanding of OC from both genetic and OMICS perspectives.

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“…Studies from our group defined mutations and polymorphisms of biologically functional genes including oncogenes, tumor suppressor genes, apoptotic genes, receptor genes and signal transduction genes in oral cancer [10][11][12][13][14][15]. With advances in technology, high throughput microarray based whole genome expression analysis and whole genome association studies (GWAS), confirmed by nucleotide sequencing and allele specific oligonucleotide assays for examination of the genome, we identified several SNPs associated with increased or decreased risk of developing oral cancer [16][17][18][19][20][21][22]. Several global studies have highlighted the role of specific SNPs in oral cancer predisposition and oral cancer [17,[23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Clinical Implications of Single Nucleotide Polymorphisms in Oral Cancer

Saranath¹

2022

MRD

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Background: Oral cancer is a high incidence cancer with well-established risk factors including tobacco, alcohol, areca nut, and HR-HPV 16/18. Additional risk factors such as Single Nucleotide Polymorphisms (SNPs) associated with genetic susceptibility, disease progression and prognosis. A comprehensive review of clinically relevant SNPs is synopsized in the current article. Methods:The PubMed repository was primarily used to retrieve articles using a combined keyword search. We selected 81 eligible studies examining association of SNPs with oral cancer, published in peer reviewed journals, between January 2000 and March 2022, with a focus on SNPs and prediction of oral cancer survival indicating response to therapy.Results: Twelve SNPs including ERCC5 rs17655, ERCC1 rs735482, TP53 rs1042522, MDM2 rs2279744, MTHFR rs1801133, MTHFR rs1801131, MSH2 rs3732183, MLH1 rs1800734, FADS1 rs174549, XPD rs13181, XPD rs1799793, and TGFBR1 rs33438 emerged as potential SNP markers for prediction of oral cancer survival and response to therapy. Conclusion:The risk-loci may be indicated potential biomarkers for early oral cancer detection, better patient prognosis and also serve as molecular targets for novel therapies.

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Single Nucleotide Polymorphisms and Risk of Oral Cancer: Indian Case-Control Study

Cited by 6 publications

References 48 publications

Survivin Promoter Polymorphism (-31 C/G): A Genetic Risk Factor for Oral Cancer

Survivin Promoter Polymorphism (-31 C/G): A Genetic Risk Factor for Oral Cancer

Personalised Precision Medicine - A Novel Approach for Oral Cancer Management

Clinical Implications of Single Nucleotide Polymorphisms in Oral Cancer

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