Single nucleotide polymorphism rs4648298 in miRNAs hsa-miR21 and hsa-miR590 binding site of COX gene is a strong colorectal cancer determinant

Mosallaei, Meysam; Simonian, Miganoosh; Ahangari, Fateme; Miraghajani, Maryam; Mortazavi, Deniz; Salehi, Ahmad; Khosravi, Sharifeh; Salehi, Roya

doi:10.21037/jgo.2017.11.01

Cited by 13 publications

(3 citation statements)

References 38 publications

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“…In contrast with these results, Mosallaei et al observed a significant relationship between COX2 rs4648298 polymorphism (AA genotype) and a reduced risk of CRC in the Iranian population (OR = 0.14; 95% CI: 0.05-0.34; P <0.001). Interestingly, they found this significant association only in non-smokers (28). This finding suggests that environmental factors may influence the association between the COX gene polymorphism and CRC.…”

Section: Cyclooxygenase (Cox) Gene Polymorphism and Risk Of Crcmentioning

confidence: 93%

Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review

Majidi¹,

Tajaddod²,

Abdollahi³

et al. 2022

Front. Oncol.

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ObjectiveGenetics and dietary factors play important roles in the development of colorectal cancer (CRC). However, the underlying mechanisms of the interactions between CRC, gene polymorphisms, and dietary fat are unclear. This review study investigated the effects of polymorphisms of arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) genes in the association between CRC and dietary fat.MethodsAll the related papers published from 2000 to 2022 were collected from different databases such as PubMed, Science Direct, Scopus, and Cochran using related keywords such as colorectal cancer, ALOX, COX, polymorphism, and dietary fat. Non-English and unrelated documents were excluded.ResultsSome single-nucleotide polymorphisms (SNPs) in the ALOX and COX genes, such as rs2228065, rs6413416, and rs4986832 in the ALOX gene, and rs689465 in the COX gene may play significant roles in the association between the risk of CRC and dietary fats. SNPs of ALOX and COX genes may influence the effects of dietary fatty acids on the risk of CRC.ConclusionSome polymorphisms of the ALOX and COX genes may have important roles in the effects of dietary fat on the risk of CRC. If future studies confirm these results, dietary recommendations for preventing colorectal cancer may be personalized based on the genotype of the ALOX and COX genes.

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Section: Cyclooxygenase (Cox) Gene Polymorphism and Risk Of Crcmentioning

confidence: 93%

Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review

Majidi¹,

Tajaddod²,

Abdollahi³

et al. 2022

Front. Oncol.

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“…In this way, recent genome-wide association studies (GWAS) determined multiple RA-related single nucleotide polymorphisms (SNPs). The most frequent type of variations in the human genome is single nucleotide polymorphism (SNP) that they exist once almost in every 300 nucleotides ( 11 - 13 ). The tumor necrosis factor alpha inducible protein 3 gene (TNFAIP3) is one of the identified candidate loci by several GWAS that conducted to recognize new predisposing genes of the main autoimmune diseases ( 14 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

Single nucleotide polymorphism rs5029937 in TNFAIP3 gene is correlated with risk of rheumatoid arthritis

Pakzad

Yousefisadr

Karimzadeh

et al. 2021

mjiri

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Studies have shown that TNFAIP3 is fundamental for regulating inflammation by dismissing TNF-induced NFKB responses through tumor necrosis factor receptor (TNFR), TLR, IL1R and NOD2. Variations in the TNFAIP3 gene, as a key regulator of inflammatory signaling pathways, seem to dramatically contribute to autoimmunity. →What this article adds:Our results demonstrate that combination of TT+TG compared with the GG genotype in rs5029937 polymorphism increased the risk of disease. On the other hand, individuals with allele T were more frequently affected with RA than subjects with G allele.

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“…[22] On the other hand, rs7579 in 3’UTR of mRNA may impact microRNAs functions by influence in the secondary structure of 3’UTR and thermodynamic features of hybridization site. [2324] These single-nucleotide polymorphisms ( SNPs ) also can deregulate expression of the target gene by a change in binding capacity of microRNAs (miRNAs). Investigate on miRNA and SNP databases (such as miRBase, miRanda, and mirdsnp) shows that this polymorphism (rs7579) is in the vicinity of hsa-miR-3150a, hsa-miR-676, hsa-miR-450a, and hsa-miR-567 binding site that could influence on miRNA-mRNA interaction and sequentially deregulate SEPP1 expression.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of SEPP1 and Selenoprotein S Gene Polymorphisms (rs7579 and rs34713741) in Relation to Colorectal Cancer Susceptibility in Subset of Iranian Population: A Case–control Study

et al. 2019

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Background: Colorectal cancer (CRC) is rated as the second cause of cancer death worldwide. Selenium (Se) has antioxidant activity and antitumor effect, especially in colon cancer. This important role occurs through selenoproteins. Low Se intake or low plasma Se and selenoproteins concentrations are associated with higher risk of CRC. rs7579 polymorphism in 3’ untranslated region of the SEPP1 gene can effect on selenocysteine incorporation during protein synthesis and also effect on microRNA –messengerRNA interaction and sequentially change in SEPP1 expression. rs34713741 polymorphism as a promoter variant in selenoprotein S ( SELS ) gene can effect on SElS expression and finally lead to increased CRC risk. Methods: A case–control study using 60 CRC patients and 74 noncancerous counterparts were undertaken in order to determine rs7579 and rs34713741 genotypes using real-time polymerase chain reaction high-resolution melting method. Results: We found an association of borderline statistical significance between allele A for rs7579 in SEPP 1 and CRC risk (adjusted odds ratio = 1.63; confidential interval = 0.99–2.07; P = 0.05). The frequency of genotypes rs34713741 of the mentioned polymorphisms was not significantly different between case and control groups ( P = 0.23 and P = 0.93, respectively). Conclusions: The results suggest that these polymorphisms probably has not a substantial role in Iranian CRC risk and is not a serious potential factor in risk assessment of mentioned disease among Iranians.

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Single nucleotide polymorphism rs4648298 in miRNAs hsa-miR21 and hsa-miR590 binding site of COX gene is a strong colorectal cancer determinant

Abstract: Our results suggest significant correlation between rs4648298 polymorphism and CRC risk in Iranian population.

Cited by 13 publications

References 38 publications

Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review

Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review

Single nucleotide polymorphism rs5029937 in TNFAIP3 gene is correlated with risk of rheumatoid arthritis

Evaluation of SEPP1 and Selenoprotein S Gene Polymorphisms (rs7579 and rs34713741) in Relation to Colorectal Cancer Susceptibility in Subset of Iranian Population: A Case–control Study

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