2006
DOI: 10.1016/j.fertnstert.2005.12.073
|View full text |Cite
|
Sign up to set email alerts
|

Single nucleotide polymorphism in exon 17 of the insulin receptor gene is not associated with polycystic ovary syndrome in a Korean population

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

6
37
1

Year Published

2009
2009
2022
2022

Publication Types

Select...
4
3

Relationship

0
7

Authors

Journals

citations
Cited by 40 publications
(44 citation statements)
references
References 26 publications
6
37
1
Order By: Relevance
“…Among these polymorphisms, a C/T SNP at His1058 in exon 17 has been reported to be significantly associated with PCOS in two independent studies in Caucasian and Chinese women (25,26). A subsequent study from Korea however, failed to confirm this association (27). Also, the possible relationship between this polymorphism and PCOS associated traits has not been explored so far.…”
Section: Introductionmentioning
confidence: 92%
See 2 more Smart Citations
“…Among these polymorphisms, a C/T SNP at His1058 in exon 17 has been reported to be significantly associated with PCOS in two independent studies in Caucasian and Chinese women (25,26). A subsequent study from Korea however, failed to confirm this association (27). Also, the possible relationship between this polymorphism and PCOS associated traits has not been explored so far.…”
Section: Introductionmentioning
confidence: 92%
“…Other studies showed that the number and affinity of insulin receptor is not altered in PCOS but its tyrosine phosphorylation status and subsequent signaling is affected, suggesting the defect may lie in the b-chain (16,20). Studies to determine mutations in INSR failed to find any major variations; however, several polymorphisms were identified (21)(22)(23)(24)(25)(26)(27)(28). The most frequent of these were at exon 17, which encodes the partial tyrosine kinase domain containing the ATP binding site of INSR, important for its downstream signaling (21)(22)(23)(24)(25)(26)(27)(28).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…However, replication of this association has been highly variable. Two studies found increased frequency of His1058 T allele in PCOS patients from China and India [23,24]; whereas few other studies did not see a significant association in Korean and Turkish PCOS patients [25][26][27], although it should be noted that all these studies lacked power due to small sample sizes. To overcome this limitation, Ioannidis in 2010 combined the data from these studies for a meta-analysis of the His1058 C/T polymorphism in a total of 795 cases and 576 controls, and estimated the combined odds ratio (OR) of 1.28 (95% confidence interval (CI) 0.88-1.85), which suggests that His1058 variation is likely not a major contributor to the etiology of PCOS [28].…”
Section: Insulin Receptor (Insr)mentioning
confidence: 99%
“…Lee [25] sequenced the exons of INSR in 24 healthy Korean women to survey all coding variation present in the general population; 9 SNPs identified from the resequencing study were then genotyped in 134 Korean women with PCOS and 100 body mass index (BMI) matched controls. They found no significant associations, except with a novel SNP, rs2252673, for which, the minor T allele confers a modest protective effect to the carriers [26].…”
Section: Insulin Receptor (Insr)mentioning
confidence: 99%