Single nucleotide polymorphism in CD36: Correlation to peptide YY levels in obese and non-obese adults

Muthuswamy, Karthi; Shanmugamprema, Deepankumar; Ponnusamy, Vinithra; Subramanian, Gowtham; Vasanth, Krishnan; Raj, Palanivelu Praveen; Senthilkumar, Rajasekaran; Selvakumar, S.

doi:10.1016/j.clnu.2021.02.044

Cited by 14 publications

(13 citation statements)

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“…Thus the authors suggested that the variation at rs1761667 may have ancestry-specific effects on fat perception ( 53 ). Similar results were observed by Karthi et al ( 63 ) in a population of Indian adults. Participants with the AA/AG genotype exhibited a significantly higher LA detection threshold and higher BMI than those with the GG genotype ( 63 ).…”

Section: Discussionsupporting

confidence: 91%

“…Similar results were observed by Karthi et al ( 63 ) in a population of Indian adults. Participants with the AA/AG genotype exhibited a significantly higher LA detection threshold and higher BMI than those with the GG genotype ( 63 ). Therefore, there is growing evidence that the A allele of the rs1761667 SNP is associated with lower fat taste sensitivity.…”

Section: Discussionsupporting

confidence: 91%

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A systematic review of the biological mediators of fat taste and smell

Jaime-Lara

Brooks

Vizioli

et al. 2023

Physiological Reviews

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Taste and smell play a key role in our ability to perceive foods. Overconsumption of highly palatable energy-dense foods can lead to increased caloric intake and obesity. Thus there is growing interest in the study of the biological mediators of fat taste and associated olfaction as potential targets for pharmacologic and nutritional interventions in the context of obesity and health. The number of studies examining mechanisms underlying fat taste and smell has grown rapidly in the last 5 years. Therefore, the purpose of this systematic review is to summarize emerging evidence examining the biological mechanisms of fat taste and smell. A literature search was conducted of studies published in English between 2014 and 2021 in adult humans and animal models. Database searches were conducted using PubMed, EMBASE, Scopus, and Web of Science for key terms including fat/lipid, taste, and olfaction. Initially, 4,062 articles were identified through database searches, and a total of 84 relevant articles met inclusion and exclusion criteria and are included in this review. Existing literature suggests that there are several proteins integral to fat chemosensation, including cluster of differentiation 36 (CD36) and G protein-coupled receptor 120 (GPR120). This systematic review will discuss these proteins and the signal transduction pathways involved in fat detection. We also review neural circuits, key brain regions, ingestive cues, postingestive signals, and genetic polymorphism that play a role in fat perception and consumption. Finally, we discuss the role of fat taste and smell in the context of eating behavior and obesity.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

A systematic review of the biological mediators of fat taste and smell

Jaime-Lara

Brooks

Vizioli

et al. 2023

Physiological Reviews

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“…In the present study, we looked at the effects of a voluntary exercise regimen combined with a well-known obesogenic diet. While there is growing evidence of a link between taste sensitivity and obesity, [34][35][36][37][38][39][40] the molecular mechanisms that contribute to the positive benefits of physical exercise on the taste phenotype remain unknown. The main goal of this study is to see if dietary fat taste perception differs between active and SED people, to gain a better of the factors that influence energy balance and nutritionary choices based on physical activity, as well as nutritional interventions and behavioral changes.…”

Section: Discussionmentioning

confidence: 99%

Exercise modifies fatty acid perception and metabolism

et al. 2023

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Aim Obesity is a major public health issue, which is associated with several chronic diseases. In rodents, voluntary wheel running (VWR) is a type of exercise that influences ingestive behavior. This study aims to investigate the possible function of VWR activity in the perception of fat taste and if it mitigates the immediate effects of fatty acid (FA) ingestion. Methods Male C57BL/6 mice were arbitrarily assigned to either a sedentary (SED) lifestyle or free access to a running wheel after 5 weeks of dietary regimen. Later these mice groups were used in the investigations on fat preference, metabolic tolerance, and electrophysiology. Diet‐induced alterations in CD36 and GPR120 expression that are related to fat perception and the capacitative calcium signaling caused by FA in taste bud cells (TBCs) were also examined. Results In obese groups, VWR temporarily reduced body weight, demonstrated improvement in preference scores for FA, and recovered from a deterioration in glucose homeostasis. In CD36‐positive TBCs, electrophysiological investigations showed alterations in [Ca2+]i caused by FA. Further, in the TBCs of circumvallate papillae, there are differences in the expression of the genes CD36 and GPR120 between the active and SED controls. Obese mice also show lower incentive salience for long‐chain fatty acids (LCFA) and adapted to the reward system of VWR which may lead to improved incentive salience accredited to wheel running. Conclusion In conclusion, this study provides the first evidence that VWR causes orosensory adaptations to fat and appears to alter taste preference for LCFAs.

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“…In high‐fat diet‐induced obese rats, CD36 expression in the circumvallate papillae is dramatically reduced (Zhang et al, 2011). Our previous report on CD36 polymorphism at rs1761667 provided a strong association between obesity and oral FA detection threshold and dietary fat consumption (Muthuswamy et al, 2021). The rs1527483 SNP of CD36 has also been associated with an increased risk of obesity in case–control and cross‐sectional studies, as well as to the perception of fat and intake of fatty foods (Bokor et al, 2010; Meng et al, 2021; Ong et al, 2017; Plesník et al, 2018).…”

Section: Introductionmentioning

confidence: 90%

CD36 genetic polymorphism and salivary cues are associated with oleic acid sensitivity and dietary fat intake

et al. 2023

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There is a lack of research on the combined effects of genetic variations (specifically CD36 SNPs—rs1761667 and rs1527483), dietary food habits (vegetarian or not), and the salivary environment on obesity and taste sensitivity, especially in the Indian population. The current study aims to better understand the relationship between impaired taste perception, fat consumption, higher BMI and obesity development by examining the combined association between CD36 SNPs, oleic acid (OA) detection threshold, and food habits among Indian participants. Furthermore, the relationship between oral fatty acid (FAs) sensitivity and taste physiology factors linked to inflammation and salivary proteins was considered. Participants with the minor allele (AA/AG) of CD36 (in both rs1527483 and rs1761667) consumed more fat, particularly saturated FAs (p = 0.0351). Salivary lipopolysaccharide, which causes inflammation, was significantly greater in non‐vegetarians with a higher BMI (p < 0.05), and it exhibited a negative correlation (r = −0.232 and p < 0.05) with Ki67 gene expression, a marker for taste progenitor cells. A positive correlation (r = 0.474, p = 0.04) between TLR4 mRNA levels and the OA detection threshold was also observed. Participants with BMI > 25 kg/m2 had substantially higher TNF‐α and IL‐6 receptor mRNA expression levels, but there were no significant differences between the vegetarian and non‐vegetarian groups. However, salivary CA‐VI, which has a buffering capability on the oral environment, was lower in non‐vegetarian adults with BMI >25. Thus, it was shown that non‐vegetarians with overweight and obesity in India were in at‐risk groups for the CD36 SNP (AA/AG at rs1761667 and rs1527483) and had higher levels of inflammatory markers, which exacerbated alterations in food behaviour and physiological changes, indicating their relevance in the development of obesity.

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Single nucleotide polymorphism in CD36: Correlation to peptide YY levels in obese and non-obese adults

Cited by 14 publications

References 50 publications

A systematic review of the biological mediators of fat taste and smell

A systematic review of the biological mediators of fat taste and smell

Exercise modifies fatty acid perception and metabolism

CD36 genetic polymorphism and salivary cues are associated with oleic acid sensitivity and dietary fat intake

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