Single molecule studies of dynamic platelet interactions with endothelial cells
Fabian Hauser,
Christoph Naderer,
Eleni Priglinger
et al.
Abstract:A biotechnological platform consisting of two-color 3D super-resolution readout and a microfluidic system was developed to investigate platelet interaction with a layer of perfused endothelial cells under flow conditions. Platelet activation has been confirmed via CD62P clustering on the membrane and mitochondrial morphology of ECs at the single cell level were examined using 3D two-color single-molecule localization microscopy and classified applying machine learning. To compare binding of activated platelets… Show more
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