Single-Molecule Rupture Dynamics on Multidimensional Landscapes

Abstract

We explore emergent effects of multidimensionality of the free energy landscape on single-molecule kinetics under constant force. The proposed minimal model reveals the existence of a spectrum of unusual scenarios for the force-dependent lifetime, all of which are shown to occur on a free energy landscape with a single transition state. We present an analytical solution that governs single-molecule responses to a constant force and relates them to microscopic parameters of the system.

Plausible explanation for theΔ5/2+(2000)puzzle

“…[11]. Moreover a recent new data analysis has reported a ∆ 5/2 + with a pole position at 1738 MeV [12]. In this last analysis, incorporating πN, γN → πN, ηN, ππN data, the resonance is obtained from a bare state at 2162 MeV through its coupling to meson-baryon channels.…”

Resolving the molecular mechanism of cadherin catch bond formation

“…These include energy landscapes with one bound state and two unbinding pathways 43 ; an energy landscape with two bound states, one of which is preferentially stabilized by force 44,45 ; bond dissociation along a multidimensional landscape where the direction of the tensile force and the reaction coordinate are misaligned [46][47][48] ; a freeenergy landscape with dynamic disorder that thermally fluctuates with time 49,50 ; and allosteric deformation models where external force changes the structure of the receptor either directly at the ligand-binding site 51 or at a distal location that ultimately propagates the deformation to the binding pocket [52][53][54][55] . Our simulations suggest that X-dimers form catch bonds via a slidingrebinding mechanism where a pulling force flexes the ectodomain and slides opposing EC1 domains resulting in the formation of de novo, force-induced H-bonds.…”

Experimental study of theP11(1440)andD13(1520)Mokeev1, Burkert2, Elouadrhiri3 et al. 2012Phys. Rev. C12731680View full textAdd to dashboardCite

“…The meson-baryon cloud has a profound impact on the resonance spectrum. For example, in the P 11 partial wave a single bare resonance pole located at W =1.76 GeV, being affected by mesonbaryon dressing, splits into three poles located on different Riemann sheets [21,22]. Two of them with Re(W ) ≈ 1.36 GeV correspond to the physical Roper resonance.…”

“…Studies of meson-baryon dressing contributions to γ v pN * electrocouplings and resonance hadronic decay amplitudes, carried out at the Excited Baryon Analysis Center (EBAC) at Jefferson Lab [17][18][19][20][21][22][23][24], have extended our insight into the spectrum and structure of excited nucleon states considerably. The contributions from meson-baryon dressing to the P 11 (1440) and D 13 (1520) electrocouplings were determined from a global analysis of the world data on πN scattering and π + n, π 0 p electroproduction off protons within the framework of the EBAC dynamical coupledchannel approach (EBAC-DCC) [23].…”